Protein detail

CAC1E

Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)

Entry name CAC1E	UniProt ID Q15878	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 24	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Protein Function (5)

Voltage-gated ion channels:Voltage-Gated Calcium Channels
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

90..108; Helical; Name=S1 of repeat I; 128..146; Helical; Name=S2 of repeat I; 159..173; Helical; Name=S3 of repeat I; 186..205; Helical; Name=S4 of repeat I; 224..244; Helical; Name=S5 of repeat I; 327..350; Helical; Name=S6 of repeat I; 477..496; Helical; Name=S1 of repeat II; 510..529; Helical; Name=S2 of repeat II; 539..557; Helical; Name=S3 of repeat II; 568..586; Helical; Name=S4 of repeat II; 606..625; Helical; Name=S5 of repeat II; 679..703; Helical; Name=S6 of repeat II; 1149..1165; Helical; Name=S1 of repeat III; 1190..1209; Helical; Name=S2 of repeat III; 1218..1240; Helical; Name=S3 of repeat III; 1255..1272; Helical; Name=S4 of repeat III; 1292..1311; Helical; Name=S5 of repeat III; 1399..1422; Helical; Name=S6 of repeat III; 1480..1498; Helical; Name=S1 of repeat IV; 1514..1533; Helical; Name=S2 of repeat IV; 1542..1560; Helical; Name=S3 of repeat IV; 1572..1590; Helical; Name=S4 of repeat IV; 1610..1629; Helical; Name=S5 of repeat IV; 1699..1724; Helical; Name=S6 of repeat IV

Transmembrane Count

Ensembl

ENSG00000198216

Entrez Gene Symbol

CACNA1E

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificEsophageal apical cells

Function & Pathway7

Protein Function (5)

Voltage-gated ion channels:Voltage-Gated Calcium Channels
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (5)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence25

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CACNA1E	CDK2	P24941	S	2,073	phosphorylation	KEA	KEA:17570479
CACNA1E	GSK3B	P49841	S	2,073	phosphorylation	KEA	KEA:17570479
CACNA1E	MAPK13	O15264	S	2,073	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (20)

20 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CACNA1E H2AX H2BC21 H3-3A H4C4 HSPA1B MCM4 MCM5 SSRP1 SUMO2 SUPT16H TOP1 TOP2A	P0DMV9 P11387 P11388 P16104 P33991 P33992 P61956 P62805 P84243 Q08945 Q15878 Q16778 Q9Y5B9	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6738
	CACNA1E H2AX H2BC21 H3-3A H4C4 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 SSRP1 SUPT16H TOP2A	P11388 P16104 P25205 P33991 P33992 P33993 P49736 P62805 P84243 Q08945 Q14566 Q15878 Q16778 Q9Y5B9	1:1:1:1:1:1:1:2:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3956

Sequence, Structure & Domains16

Sequences

Length

2,313

Mass

261,731

Sequence

MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESNNACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha-1E; IsoId=Q15878-1; Sequence=Displayed; Name=2; Synonyms=Alpha-1E-1; IsoId=Q15878-2; Sequence=VSP_000937, VSP_024817; Name=3; Synonyms=Alpha-1E-3; IsoId=Q15878-3; Sequence=VSP_024817

Alternative Sequence

748..766; Missing (in isoform 2); 1967..2009; Missing (in isoform 2 and isoform 3)

3D Structural Models

Turn

84..86; 91..94; 125..127; 155..157; 181..184; 285..288; 324..327; 465..467; 528..530; 533..537; 626..629; 655..658; 673..676; 682..687; 689..696; 713..723; 1289..1292; 1312..1314; 1326..1328; 1393..1396; 1410..1412; 1526..1528; 1768..1770; 1773..1775; 1822..1824

Helix

95..108; 119..124; 128..144; 159..174; 178..180; 190..198; 199..203; 205..217; 218..221; 224..242; 298..306; 311..322; 328..339; 341..357; 361..384; 461..464; 468..472; 476..492; 502..527; 539..559; 570..582; 586..598; 601..625; 643..654; 659..669; 677..681; 697..712; 724..727; 777..787; 1147..1150; 1158..1171; 1181..1208; 1223..1241; 1251..1257; 1259..1263; 1265..1267; 1268..1271; 1273..1288; 1293..1311; 1337..1339; 1358..1369; 1374..1382; 1397..1400; 1402..1409; 1413..1424; 1434..1437; 1442..1446; 1467..1469; 1471..1475; 1481..1494; 1505..1525; 1529..1532; 1534..1537; 1543..1560; 1575..1580; 1581..1584; 1585..1588; 1593..1605; 1610..1629; 1649..1660; 1665..1671; 1699..1722; 1723..1725; 1726..1729; 1738..1741; 1743..1751; 1762..1767; 1784..1790; 1796..1798; 1805..1817; 1825..1842; 1848..1854; 1868..1882

Beta Strand

87..90; 113..115; 148..151; 243..245; 249..253; 256..258; 269..271; 274..281; 293..295; 640..642; 1152..1155; 1178..1180; 1244..1247; 1316..1320; 1331..1335; 1342..1345; 1348..1350; 1476..1480; 1540..1542; 1561..1564; 1568..1570; 1638..1640; 1642..1644; 1646..1648; 1673..1675; 1682..1684; 1688..1690; 1733..1735; 1755..1757; 1791..1794; 1860..1862

3D Structure

Electron microscopy (4); X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

866..875; Polar residues; 913..926; Basic residues; 933..945; Low complexity; 955..983; Basic and acidic residues; 2012..2023; Polar residues; 2055..2064; Low complexity; 2065..2085; Basic and acidic residues; 2101..2118; Basic and acidic residues; 2129..2152; Polar residues; 2210..2225; Low complexity

Repeat

76..354; I; 462..706; II; 1140..1426; III; 1463..1726; IV

Domain (CC)

Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.

Domain (FT)

1739..1774; EF-hand

Region

1..38; Disordered; 374..391; Binding to the beta subunit; 729..774; Disordered; 851..984; Disordered; 1103..1125; Disordered; 1970..2170; Disordered; 2206..2225; Disordered; 2263..2295; Disordered

Protein Families (2)

Calcium channel alpha-1 subunit (TC 1.A.1.11) family
CACNA1E subfamily

Sequence Similarities

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.

Clinical Relevance3

Related Diseases (2)

Heart failure Unspecific body region injury

Biomarker

Investigative; Terminated

Drugs (11)

GABAPENTIN ENACARBIL SULOCTIDIL PHLOROGLUCINOL CELECOXIB BEPRIDIL HYDROCHLORIDE IMAGABALIN ATAGABALIN TERODILINE HYDROCHLORIDE GABAPENTIN NULL PREGABALIN

Supporting Publications1

PMID	Title	Abstract
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available