Protein detail
CAC1E
Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)
Protein symbol CAC1E | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 24 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Voltage-dependent R-type calcium channel subunit alpha-1E (Brain calcium channel II) (BII) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Voltage-gated calcium channel subunit alpha Cav2.3)
Protein Function
- Voltage-gated ion channels:Voltage-Gated Calcium Channels
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
90..108; Helical; Name=S1 of repeat I; 128..146; Helical; Name=S2 of repeat I; 159..173; Helical; Name=S3 of repeat I; 186..205; Helical; Name=S4 of repeat I; 224..244; Helical; Name=S5 of repeat I; 327..350; Helical; Name=S6 of repeat I; 477..496; Helical; Name=S1 of repeat II; 510..529; Helical; Name=S2 of repeat II; 539..557; Helical; Name=S3 of repeat II; 568..586; Helical; Name=S4 of repeat II; 606..625; Helical; Name=S5 of repeat II; 679..703; Helical; Name=S6 of repeat II; 1149..1165; Helical; Name=S1 of repeat III; 1190..1209; Helical; Name=S2 of repeat III; 1218..1240; Helical; Name=S3 of repeat III; 1255..1272; Helical; Name=S4 of repeat III; 1292..1311; Helical; Name=S5 of repeat III; 1399..1422; Helical; Name=S6 of repeat III; 1480..1498; Helical; Name=S1 of repeat IV; 1514..1533; Helical; Name=S2 of repeat IV; 1542..1560; Helical; Name=S3 of repeat IV; 1572..1590; Helical; Name=S4 of repeat IV; 1610..1629; Helical; Name=S5 of repeat IV; 1699..1724; Helical; Name=S6 of repeat IV
Transmembrane Count
24
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEsophageal apical cells
Function & Pathway
Protein Function
- Voltage-gated ion channels:Voltage-Gated Calcium Channels
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CACNA1E | CDK2 | P24941 | S | 2,073 | phosphorylation | KEA | KEA:17570479 |
| CACNA1E | GSK3B | P49841 | S | 2,073 | phosphorylation | KEA | KEA:17570479 |
| CACNA1E | MAPK13 | O15264 | S | 2,073 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
20 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 2 of 2Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CACNA1EH2AXH2BC21H3-3AH4C4HSPA1BMCM4MCM5SSRP1SUMO2SUPT16HTOP1TOP2A | P0DMV9P11387P11388P16104P33991P33992P61956P62805P84243Q08945Q15878Q16778Q9Y5B9 | 1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6738 | ||
| CACNA1EH2AXH2BC21H3-3AH4C4MCM2MCM3MCM4MCM5MCM6MCM7SSRP1SUPT16HTOP2A | P11388P16104P25205P33991P33992P33993P49736P62805P84243Q08945Q14566Q15878Q16778Q9Y5B9 | 1:1:1:1:1:1:1:2:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC3956 |
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
2,313
Mass
261,731
Sequence
MARFGEAVVARPGSGDGDSDQSRNRQGTPVPASGQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPSLYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHGNCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVVLTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTVVHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYLQQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLEPEVSELKSVQPSNHGIYLPSDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIRDKRSNSSWLEEFSMERSSENTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSPDVSRCNSEERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRSRRQLPPVPPKPRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESNNACLTESSNSPHPQQSQHASPQRYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Alpha-1E; IsoId=Q15878-1; Sequence=Displayed; Name=2; Synonyms=Alpha-1E-1; IsoId=Q15878-2; Sequence=VSP_000937, VSP_024817; Name=3; Synonyms=Alpha-1E-3; IsoId=Q15878-3; Sequence=VSP_024817
Alternative Sequence
748..766; Missing (in isoform 2); 1967..2009; Missing (in isoform 2 and isoform 3)
3D Structural Models
Turn
84..86; 91..94; 125..127; 155..157; 181..184; 285..288; 324..327; 465..467; 528..530; 533..537; 626..629; 655..658; 673..676; 682..687; 689..696; 713..723; 1289..1292; 1312..1314; 1326..1328; 1393..1396; 1410..1412; 1526..1528; 1768..1770; 1773..1775; 1822..1824
Helix
95..108; 119..124; 128..144; 159..174; 178..180; 190..198; 199..203; 205..217; 218..221; 224..242; 298..306; 311..322; 328..339; 341..357; 361..384; 461..464; 468..472; 476..492; 502..527; 539..559; 570..582; 586..598; 601..625; 643..654; 659..669; 677..681; 697..712; 724..727; 777..787; 1147..1150; 1158..1171; 1181..1208; 1223..1241; 1251..1257; 1259..1263; 1265..1267; 1268..1271; 1273..1288; 1293..1311; 1337..1339; 1358..1369; 1374..1382; 1397..1400; 1402..1409; 1413..1424; 1434..1437; 1442..1446; 1467..1469; 1471..1475; 1481..1494; 1505..1525; 1529..1532; 1534..1537; 1543..1560; 1575..1580; 1581..1584; 1585..1588; 1593..1605; 1610..1629; 1649..1660; 1665..1671; 1699..1722; 1723..1725; 1726..1729; 1738..1741; 1743..1751; 1762..1767; 1784..1790; 1796..1798; 1805..1817; 1825..1842; 1848..1854; 1868..1882
Beta Strand
87..90; 113..115; 148..151; 243..245; 249..253; 256..258; 269..271; 274..281; 293..295; 640..642; 1152..1155; 1178..1180; 1244..1247; 1316..1320; 1331..1335; 1342..1345; 1348..1350; 1476..1480; 1540..1542; 1561..1564; 1568..1570; 1638..1640; 1642..1644; 1646..1648; 1673..1675; 1682..1684; 1688..1690; 1733..1735; 1755..1757; 1791..1794; 1860..1862
3D Structure
Electron microscopy (4); X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
866..875; Polar residues; 913..926; Basic residues; 933..945; Low complexity; 955..983; Basic and acidic residues; 2012..2023; Polar residues; 2055..2064; Low complexity; 2065..2085; Basic and acidic residues; 2101..2118; Basic and acidic residues; 2129..2152; Polar residues; 2210..2225; Low complexity
Repeat
76..354; I; 462..706; II; 1140..1426; III; 1463..1726; IV
Domain (CC)
Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Domain (FT)
1739..1774; EF-hand
Region
1..38; Disordered; 374..391; Binding to the beta subunit; 729..774; Disordered; 851..984; Disordered; 1103..1125; Disordered; 1970..2170; Disordered; 2206..2225; Disordered; 2263..2295; Disordered
Protein Families
- Calcium channel alpha-1 subunit (TC 1.A.1.11) family
- CACNA1E subfamily
Sequence Similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.
Clinical Relevance
Related Diseases
Biomarker
Investigative; Terminated