Protein detail
ADRM1
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
Entry name ADRM1 | UniProt ID | EVMP confidence score 0.75 |
Supporting publications (n) 24 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Proteasomal ubiquitin receptor ADRM1 (110 kDa cell membrane glycoprotein) (Gp110) (Adhesion-regulating molecule 1) (ARM-1) (Proteasome regulatory particle non-ATPase 13) (hRpn13) (Rpn13 homolog)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
ARM1GP110PSMD16Rpn13
Gene Description
ADRM1 26S proteasome ubiquitin receptor
Chromosome
20
Position
62302093-62308862
Supporting publications (n)
24
EVMP confidence score
0.75
Fluorescence & Localization3
Tissue Specificheart muscleCell SpecificCardiomyocytes
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
KEGG (9)
- hsa03050 Proteasome
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05014 Amyotrophic lateral sclerosis
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05020 Prion disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05169 Epstein-Barr virus infection
Reactome (134)
- R-hsa-382556 abc family proteins mediated transport
- R-hsa-5619084 abc transporter disorders
- R-hsa-176814 activation of apc c and apc c cdc20 mediated degradation of mitotic proteins
- R-hsa-1169091 activation of nf kappab in b cells
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-9931269 ampk induced erad and lysosome mediated degradation of pd l1 cd274
- R-hsa-1236975 antigen processing cross presentation
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-174178 apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1
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Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence17
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (11)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains13
Sequences
Length
407
Mass
42,153
Sequence
MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD
3D Structural Models
Turn
64..66; 191..195; 254..256; 349..351
Helix
99..101; 117..129; 266..273; 288..291; 294..297; 300..302; 304..310; 311..313; 324..326; 327..332; 334..348; 353..358; 363..371; 374..383
Beta Strand
23..34; 37..40; 45..51; 57..63; 69..75; 79..84; 89..91; 93..98; 104..109; 111..114; 202..204; 249..253; 276..278; 282..284; 386..388; 395..397
3D Structure
NMR spectroscopy (10); X-ray crystallography (11)
Domain & Motif Annotations
Compositional Bias
387..398; Basic and acidic residues
Domain (CC)
The Pru (pleckstrin-like receptor for ubiquitin) domain mediates interactions with PSMD1 and ubiquitin. Preferential binding to the proximal subunit of 'Lys-48'-linked diubiquitin allows UCHL5 access to the distal subunit.
Domain (FT)
18..131; Pru; 277..391; DEUBAD
Region
194..259; Disordered; 253..407; Interaction with UCHL5; 379..407; Disordered
Protein Families
ADRM1 family
Sequence Similarities
Belongs to the ADRM1 family.
Clinical Relevance5
Antibody
Interaction Protein (16)
ENSG00000013275ENSG00000087191ENSG00000100519ENSG00000100764ENSG00000101843ENSG00000108671ENSG00000116750ENSG00000135018ENSG00000150991ENSG00000159352ENSG00000161057ENSG00000165916ENSG00000173692ENSG00000175166ENSG00000188021ENSG00000197170
Interaction Count
16
Interaction Dataset (4)
biogrid_opencellbiogrid_bioplexintact_biogridintact_biogrid_bioplex
Supporting Publications23
| PMID | Title | Abstract |
|---|---|---|
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 39409015 | SILAC-Based Characterization of Plasma-Derived Extracellular Vesicles in Patients Undergoing Partial Hepatectomy. | No abstract available |
| 39766158 | A Proteomic Examination of Plasma Extracellular Vesicles Across Colorectal Cancer Stages Uncovers Biological Insights That Potentially Improve Prognosis. | No abstract available |
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