Protein detail

ENOX2

Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]

Entry name ENOX2	UniProt ID Q16206	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000165675

Entrez Gene Symbol

ENOX2

Gene Synonym (3)

APK1COVA1tNOX

Gene Description

Ecto-NOX disulfide-thiol exchanger 2

Chromosome

Position

130622325-130903234

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (3)

Biological Process (3)

Canonical Pathways (3)

M70 Pid ps1 pathway
M236 Pid delta np63 pathway
M288 Pid hes hey pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence17

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ENOX2	PRKCD	Q05655	S	504	phosphorylation	Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:22659163 ProtMapper:22659163

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD	Q05655	ENOX2	Q16206	Yes	Yes	No	Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:22659163 SIGNOR:22659163 ProtMapper:22659163

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	1	40784529

Sequence, Structure & Domains9

Sequences

Length

610

Mass

70,082

Sequence

MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16206-1; Sequence=Displayed; Name=2; IsoId=Q16206-2; Sequence=VSP_015719

Alternative Sequence

1..29; Missing (in isoform 2)

Domain & Motif Annotations

Coiled Coil

293..328; 381..505

Domain (FT)

128..207; RRM

Protein Families

ENOX family

Sequence Similarities

Belongs to the ENOX family.

Clinical Relevance1

Antibody (2)

HPA000514 HPA003027

Supporting Publications1

PMID	Title	Abstract
2780759	The optimal processing of plasma samples for the determination of bicyclo-PGE in patients with malignant maxillofacial tumors.	No abstract available