Protein detail

ENOX2

Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]

Entry name
ENOX2
UniProt ID
Q16206
EVMP confidence score
0.53
Supporting publications (n)
1
Transmembrane count
Protein classification
Predicted intracellular proteins
Basic Information
Protein Names
Ecto-NOX disulfide-thiol exchanger 2 (APK1 antigen) (Cytosolic ovarian carcinoma antigen 1) (Tumor-associated hydroquinone oxidase) (tNOX) [Includes: Hydroquinone [NADH] oxidase (EC 1.-.-.-); Protein disulfide-thiol oxidoreductase (EC 1.-.-.-)]
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000165675
Entrez Gene Symbol
ENOX2
Gene Synonym (3)
APK1COVA1tNOX
Gene Description
Ecto-NOX disulfide-thiol exchanger 2
Chromosome
X
Position
130622325-130903234
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
ENOX2 fluorescence
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Canonical Pathways (3)
  • M70 Pid ps1 pathway
  • M236 Pid delta np63 pathway
  • M288 Pid hes hey pathway
Mediation Categories
Fusion and delivery mediation
Relations & Evidence17

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
ENOX2PRKCDQ05655S504phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:22659163ProtMapper:22659163

Ligand-Receptor Signaling (14)

14 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membraneplasma_membraneOmniPathYes
secretedsecretedUniProt_keywordYes
secretedsecretedUniProt_locationYes
secretedsecretedOmniPathYes
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Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
KPCDQ05655ENOX2Q16206YesYesSparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:22659163SIGNOR:22659163ProtMapper:22659163

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyELISA140784529
Sequence, Structure & Domains

Sequences

Length
610
Mass
70,082
Sequence
MQRDFRWLWVYEIGYAADNSRTLNVDSTAMTLPMSDPTAWATAMNNLGMAPLGIAGQPILPDFDPALGMMTGIPPITPMMPGLGIVPPPIPPDMPVVKEIIHCKSCTLFPPNPNLPPPATRERPPGCKTVFVGGLPENGTEQIIVEVFEQCGEIIAIRKSKKNFCHIRFAEEYMVDKALYLSGYRIRLGSSTDKKDTGRLHVDFAQARDDLYEWECKQRMLAREERHRRRMEEERLRPPSPPPVVHYSDHECSIVAEKLKDDSKFSEAVQTLLTWIERGEVNRRSANNFYSMIQSANSHVRRLVNEKAAHEKDMEEAKEKFKQALSGILIQFEQIVAVYHSASKQKAWDHFTKAQRKNISVWCKQAEEIRNIHNDELMGIRREEEMEMSDDEIEEMTETKETEESALVSQAEALKEENDSLRWQLDAYRNEVELLKQEQGKVHREDDPNKEQQLKLLQQALQGMQQHLLKVQEEYKKKEAELEKLKDDKLQVEKMLENLKEKESCASRLCASNQDSEYPLEKTMNSSPIKSEREALLVGIISTFLHVHPFGASIEYICSYLHRLDNKICTSDVECLMGRLQHTFKQEMTGVGASLEKRWKFCGFEGLKLT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16206-1; Sequence=Displayed; Name=2; IsoId=Q16206-2; Sequence=VSP_015719
Alternative Sequence
1..29; Missing (in isoform 2)

Domain & Motif Annotations

Coiled Coil
293..328; 381..505
Domain (FT)
128..207; RRM
Protein Families
ENOX family
Sequence Similarities
Belongs to the ENOX family.
Clinical Relevance
Antibody (2)
HPA000514HPA003027
Supporting Publications1
PMIDTitleRelated sentences
2780759The optimal processing of plasma samples for the determination of bicyclo-PGE in patients with malignant maxillofacial tumors.No related sentences available