Protein detail
NF2L2
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2)
Protein symbol NF2L2 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteinsTranscription factors |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (Nuclear factor, erythroid derived 2, like 2)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteinsTranscription factors
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Transcription factors:Basic domains
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
NRF-2NRF2
Gene Description
NFE2 like bZIP transcription factor 2
Chromosome
2
Position
177218667-177392756
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificsalivary glandCell SpecificFoveolar cellsSingle-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- Cancer-related genes:Mutated cancer genes
- Transcription factors:Basic domains
- Disease related genes
Cellular Component
Molecular Function
- GO:0000976 transcription cis-regulatory region binding
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0001221 transcription coregulator binding
- GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0003677 DNA binding
- GO:0003700 DNA-binding transcription factor activity
- GO:0005515 protein binding
- GO:0019904 protein domain specific binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0043565 sequence-specific DNA binding
- GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
- GO:0140693 molecular condensate scaffold activity
Biological Process
KEGG
- hsa04141 Protein processing in endoplasmic reticulum
- KEGG:hsa05012 Parkinson disease
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05208 Chemical carcinogenesis - reactive oxygen species
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05417 Lipid and atherosclerosis
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-389948 co inhibition by pd 1
- R-hsa-9707564 cytoprotection by hmox1
- R-hsa-9707616 heme signaling
- R-hsa-5663205 infectious disease
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-8951664 neddylation
- R-hsa-9818028 nfe2l2 regulates pentose phosphate pathway genes
- R-hsa-9818027 nfe2l2 regulating anti oxidant detoxification enzymes
- R-hsa-9818035 nfe2l2 regulating er stress associated genes
- R-hsa-9818026 nfe2l2 regulating inflammation associated genes
- R-hsa-9818032 nfe2l2 regulating mdr associated enzymes
- R-hsa-9818030 nfe2l2 regulating tumorigenic genes
- R-hsa-9759194 nuclear events mediated by nfe2l2
- R-hsa-597592 post translational protein modification
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-9707587 regulation of hmox1 expression and activity
- R-hsa-9818749 regulation of nfe2l2 gene expression
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909649 regulation of pd l1 cd274 transcription
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-9679506 sars cov infections
- R-hsa-9824446 viral infection pathways
Canonical Pathways
- M5880 Naba ecm affiliated
- M5885 Naba matrisome associated
- M5889 Naba matrisome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
40 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NFE2L2 | SRC | P12931 | Y | 576 | phosphorylation | REACH_ProtMapperPhosphoSiteSparser_ProtMapperProtMapper | ProtMapper:27230643ProtMapper:27233051ProtMapper:29104732 |
| NFE2L2 | PRKCI | P41743 | S | 40 | phosphorylation | PhosphoSite | |
| NFE2L2 | FGR | P09769 | Y | 576 | phosphorylation | REACH_ProtMapperPhosphoSiteSparser_ProtMapperProtMapper | ProtMapper:23434765ProtMapper:26998193 |
| NFE2L2 | GSK3B | P49841 | S | 347 | phosphorylation | Sparser_ProtMapperProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:29261130ProtMapper:29775963ProtMapper:23025925 |
| NFE2L2 | GSK3B | P49841 | S | 344 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| NFE2L2 | GSK3B | P49841 | Y | 576 | phosphorylation | RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:28128361ProtMapper:22279539ProtMapper:26674355ProtMapper:23864927 |
| NFE2L2 | GSK3B | P49841 | S | 342 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:23025925 |
| NFE2L2 | GSK3B | P49841 | S | 335 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:29261130 |
| NFE2L2 | CDK5 | Q00535 | T | 395 | phosphorylation | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:26968531 |
| NFE2L2 | CDK5 | Q00535 | S | 433 | phosphorylation | REACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper | ProtMapper:26968531 |
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CDK5 | Q00535 | NF2L2 | Q16236 | Yes | No | No | PhosphoSite_norefiPTMnetProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:25909891ProtMapper:26968531 |
| KPCZ | Q05513 | NF2L2 | Q16236 | Yes | No | No | PhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:27680214PhosphoSite:25107906PhosphoSite:27517753PhosphoSite:23645672PhosphoSite:30533198PhosphoSite:33403569PhosphoSite:12700136PhosphoSite:27143122PhosphoSite:22302998PhosphoSite:22558124PhosphoSite:26845617 |
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Protein Complex Composition
9 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Keap1-Nrf2 complex | KEAP1NFE2L2 | Q14145Q16236 | 2:1 | CompleatPDB | PDB:2fluPDB:7k2bCompleat:HC706PDB:7k2ePDB:6t7vPDB:7k2aPDB:4iflPDB:8ejrPDB:7k2dPDB:7k29PDB:7k28PDB:7k2cPDB:7k2kPDB:5wfvPDB:3zgcPDB:8ejs | 17903176 |
| Keap1-Nrf2-Cul3 complex | CUL3KEAP1NFE2L2 | Q13618Q14145Q16236 | 1:1:1 | Compleat | Compleat:HC3266 | 17903176 |
| PGAM5-KEAP1-NRF2 complex | KEAP1NFE2L2PGAM5 | Q14145Q16236Q96HS1 | 1:1:1 | CompleatCORUM | Compleat:HC3182CORUM:5805 | 18387606 |
| bZIP transcription factor complexATF4-NFE2L2 | ATF4NFE2L2 | P18848Q16236 | 1:1 | ComplexPortal | 28566324147552922366175828186491 | |
| MAFGNFE2L2 | O15525Q16236 | 2:2 | PDB | PDB:7x5gPDB:7x5fPDB:7x5e | ||
| NFE2L2PPIA | P62937Q16236 | 1:1 | PDB | PDB:8hz8 | ||
| BACH2MAFFNFE2L1NFE2L2NFE2L3RTL6 | Q14494Q16236Q6ICC9Q9BYV9Q9ULX9Q9Y4A8 | 0:0:0:0:0:0 | hu.MAP | |||
| BACH2MAFFNFE2L1NFE2L2NFE2L3 | Q14494Q16236Q9BYV9Q9ULX9Q9Y4A8 | 0:0:0:0:0 | hu.MAP2 | |||
| MAFFNFE2L1NFE2L2NFE2L3 | Q14494Q16236Q9ULX9Q9Y4A8 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
605
Mass
67,827
Sequence
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGMQQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVGNCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMPSPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHSVESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDAQCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLLKEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKPDVKKN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16236-1; Sequence=Displayed; Name=2; IsoId=Q16236-2; Sequence=VSP_025045; Name=3; IsoId=Q16236-3; Sequence=VSP_025045, VSP_046168
Alternative Sequence
1..16; Missing (in isoform 2 and isoform 3); 135..141; Missing (in isoform 3)
3D Structural Models
Turn
78..80
Helix
456..463; 470..475; 478..485; 492..556
Beta Strand
449..455
3D Structure
NMR spectroscopy (2); X-ray crystallography (18)
Domain & Motif Annotations
Compositional Bias
334..354; Polar residues; 416..430; Basic and acidic residues; 579..588; Polar residues
Motif
29..31; DLG motif; 79..82; ETGE motif
Domain (CC)
The ETGE motif, and to a lower extent the DLG motif, mediate interaction with KEAP1..
Domain (FT)
497..560; bZIP
Region
334..449; Disordered; 499..518; Basic motif; 522..529; Leucine-zipper; 571..605; Disordered; 591..596; Mediates interaction with CHD6 and is necessary to activate transcription
Protein Families
- BZIP family
- CNC subfamily
Sequence Similarities
Belongs to the bZIP family. CNC subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Drugs
PYRROLIDINE DITHIOCARBAMIC ACID, AMMONIUM SALTETHACRYNIC ACIDCHEMBL:CHEMBL578675ADEFOVIR DIPIVOXILMETHYLPARABENCHEMBL:CHEMBL586061GUGGULSTERONECHEMBL:CHEMBL225257CHEMBL:CHEMBL296021INDOLE-3-BUTYRIC ACIDNIFUROXAZIDEMITONAFIDE4-NONYLPHENOLCHEMBL:CHEMBL593366CHEMBL:CHEMBL591370CHEMBL:CHEMBL148831NITROFURANTOIN, MACROCRYSTALSCYPROTERONE ACETATECARBENOXOLONE SODIUMAMINACRINE HYDROCHLORIDETRIAMTERENEE232CHEMBL:CHEMBL429095SIMETRIDEMALINAMIDETIRATRICOLNULLSELECTIVE ESTROGEN RECEPTOR MODULATORTAMOXIFENFENAMIDONETANNIN PYROGALLOLBENZO(K)FLUORANTHENE2,4,6-TRIBROMOPHENOLCHEMBL:CHEMBL1098875PHENTOLAMINE MESYLATELY-294002BENODANILCHEMBL:CHEMBL581880BARDOXOLONE METHYLANTIMYCIN AIOXYNILNITROXOLINEANGUIDIN2-METHOXY-1,4-NAPHTHOQUINONEBRONOPOLCHEMBL:CHEMBL547269UCCF-029CHEMBL:CHEMBL599943ATORVASTATIN CALCIUM TRIHYDRATEGITOXINCHEMBL:CHEMBL77675CHEMBL:CHEMBL601353NIZOFENONEMECHLORETHAMINE HYDROCHLORIDETRIBROMOACETIC ACID2-PHENYLPHENOLMETHANESULFONIC ACID METHYL ESTERCHEMBL:CHEMBL588038PICONOLDOCEBENONEMERCAPTOPURINEBECLOMETHASONE DIPROPIONATEDIBENZ[A,H]ANTHRACENECHEMBL:CHEMBL578929MITOGEN-ACTIVATED PROTEIN KINASE INHIBITOR2-METHOXYESTRADIOLCHEMBL:CHEMBL601137CHEMBL:CHEMBL579318VITAMIN K3CHEMBL:CHEMBL163970PROPACHLORNILUTAMIDECHEMBL:CHEMBL1523215CHEMBL:CHEMBL1537417CHEMBL:CHEMBL529986TROVAFLOXACIN MESYLATEANCITABINECYCLOHEXIMIDECOUMARINRIMSULFURONCHEMBL:CHEMBL1198140GITOXIGENINCHLORPYRIFOS-METHYLCHEMBL:CHEMBL1761683PENDIMETHALINCHEMBL:CHEMBL583558FLUORODIFENNICLOSAMIDESTAUROSPORINEDEHYDRATED ALCOHOLTRICLOSANCHEMBL:CHEMBL609606OXYPHENBUTAZONEDICUMAROLTRIDECAN-1-OLSPIRAMIDETRIAMCINOLONEMETHYSTICINAZOSEMIDECHEMBL:CHEMBL530499ABSCISIC ACIDAROTINOID ACIDPROPYLPARABENDIENESTROLFEPRAZONECHEMBL:CHEMBL1304363TEBUFENOZIDEDARGLITAZONECHEMBL:CHEMBL515617PREDNISOLONE ACETATECHEMBL:CHEMBL584269CHEMBL:CHEMBL607253AURINCHEMBL:CHEMBL601933CHEMBL:CHEMBL426404HEXACHLOROPHENELASALOCID A SODIUMTRILOSTANEDIFLUNISALPROPANTHELINE BROMIDECHEMBL:CHEMBL68096FLUFENAMIC ACIDGALLIC ACIDCHEMBL:CHEMBL2094567CHEMBL:CHEMBL531268ANISOCOUMARIN HTO-901317VORINOSTATBIS(DIMETHYLAMINETHIOCARBONYL)MONOSULFIDECHEMBL:CHEMBL590422ERGOCALCIFEROLSPIPERONEAMCINAFIDEEPIGALLOCATECHIN GALLATEIONOMYCINTRIPROLIDINE HYDROCHLORIDECHEMBL:CHEMBL601757CHEMBL:CHEMBL601550DINITROPHENYLENECARBENDAZIMCHEMBL:CHEMBL531710CHEMBL:CHEMBL586982PREDNISOLONEBREFELDIN ADACTOLISIBHYDROCORTISONE BUTYRATEPREDNICARBATEDIMETHYL YELLOWDESMEDIPHAMDOCUSATE SODIUMDYDROGESTERONETOLONIUM CHLORIDECHEMBL:CHEMBL601547ACROLEINCAPSAICINDICHLORODIPHENYLDICHLOROETHYLENESTILONIUM IODIDEBUSPIRONENIHYDRAZONE8-CYCLOPENTYLTHEOPHYLLINECHEMBL:CHEMBL1287980TIOXOLONEFENHEXAMIDSIROLIMUSRECOMBINANT PROTHYMOSIN ALPHAFENTICLORTETRADECANOYLPHORBOL ACETATEVATALANIBHYDROCORTISONE VALERATECHEMBL:CHEMBL299853CHEMBL:CHEMBL1329443OXYPHENONIUM BROMIDEANGUSTIBALINGINSENOSIDE RG3DIGITOXINNORETHINDRONEPYRIDALYLENDRINCHEMBL:CHEMBL531079CHLOROXURONLOTEPREDNOLHEXESTROLNEUROPROTECTIVE AGENTLUFENURONCHEMBL:CHEMBL1257022BENZOFURANORTHOTOLIDINEALACHLORBISPHENOL ACHEMBL:CHEMBL225563CAMPTOTHECINCORTICOSTERONECHEMBL:CHEMBL199592CHEMBL:CHEMBL259784RIMEXOLONE1-NAPHTHYLISOTHIOCYANATECHEMBL:CHEMBL167316E1501BENZOQUINONECHEMBL:CHEMBL582055OXENDOLONECHEMBL:CHEMBL609027TIBOLONEFLOCTAFENINEKAMEBANINSB 242084NOCODAZOLECHEMBL:CHEMBL285157DEMETON-S-METHYLLITHOCHOLIC ACIDNANAOMYCINCHEMBL:CHEMBL2095095NEFAZODONE HYDROCHLORIDEPROCHLORAZTRICIRIBINERABEPRAZOLECLOCORTOLONEBROMETHALINBROMODICHLOROACETIC ACIDEUPAROTIN ACETATESTROPHANTHIDIN ACETATEAMLEXANOXBENZO[E]PYRENEEXEMESTANERESMETHRINFLAVONEE324RONNELETOXAZOLEMESOTRIONE2-CHLORO-5-NITRO-N-PHENYLBENZAMIDETOLPERISONE HYDROCHLORIDEIDAZOXANPARAROSANILINECHEMBL:CHEMBL1079460MEGESTROL ACETATECHEMBL:CHEMBL592363PAPAVERINEPIPOBROMANANCITABINE HYDROCHLORIDECANRENONEDIHYDROXANTHOHUMOLPHENMEDIPHAMPHLORETINLOPINAVIRFLUFENACETTBBTCHEMBL:CHEMBL601970AZACITIDINETHONZONIUM BROMIDEDACTHALMETHACHOLINE CHLORIDETETRANITROMETHANEPENTACHLORONITROBENZENECHEMBL:CHEMBL582983MOMETASONECHEMBL:CHEMBL1287983CHEMBL:CHEMBL530682OXYCARBOXINIL-6CHEMBL:CHEMBL124006SALICYLANILIDEDIPYRITHIONECURCUMINNEOSTIGMINEALFUZOSIN HYDROCHLORIDEKEPONECHEMBL:CHEMBL329673BUTYLPARABENHALCINONIDEEMETINE HYDROCHLORIDECHEMBL:CHEMBL1563896CHEMBL:CHEMBL584514CHEMBL:CHEMBL536166CHEMBL:CHEMBL167529DESACETOXYMATRICARINBITERTANOLTETRADIFONCHEMBL:CHEMBL1492017CHEMBL:CHEMBL83761HYDROXYPROGESTERONE CAPROATE (USP)DICHLORISONE ACETATEISATINCHEMBL:CHEMBL600734TRICYCLAZOLEBENOXACORPHENOLDIFENOCONAZOLETELMISARTANDIELDRINPROTEASE INHIBITORMEFENAMIC ACIDCITRIC ACIDTROGLITAZONECHEMBL:CHEMBL600692ENNIATIN BEPOETIN ALFAMETHOXYCHLORPHENYLMERCURIC ACETATEFIPEXIDE HYDROCHLORIDECIS/TRANS-ISOEUGENOLTILIQUINOLMANEBELLIPTECINE{4-[3-(4-ACETYL-3-HYDROXY-2-PROPYLPHENOXY)PROPOXY]PHENOXY}ACETIC ACIDTRYPTANTHRINNAMODENOSONAMITRAZCHEMBL:CHEMBL817824-PHENYLENEDIAMINETHIOPHANATE METHYLEPIRUBICIN HYDROCHLORIDESIDURONALL-TRANS-RETINALCHEMBL:CHEMBL576208CHEMBL:CHEMBL2002487CYMOXANILPHENOXYBENZAMINECHEMBL:CHEMBL428064CYCLOASPEPTIDE AHYCANTHONEDEFEROXAMINEHALAZONECLORGYLINE HYDROCHLORIDECHEMBL:CHEMBL1863271IROFULVENDIFLORASONE DIACETATEHEXYLRESORCINOLCHEMBL:CHEMBL1453126DECYNIUM 22CHEMBL:CHEMBL535307ALSTERPAULLONEPYRIDABENDIETHYLCARBAMAZINE CITRATEBUFOGENINCHEMBL:CHEMBL601320TRIFLUMIZOLEANDALUSOLCHEMBL:CHEMBL1170485CHEMBL:CHEMBL70582TRICHLORFONCLIOXANIDEBUPIRIMATECHEMBL:CHEMBL578636DOXORUBICIN HYDROCHLORIDECHEMBL:CHEMBL604528ORYZALIN1-NAPHTHOLTPCKHYDROCORTISONE SODIUM SUCCINATEBACLOFENBROMOCHLOROACETIC ACIDOMEGA-CHLOROACETOPHENONECLOROPHENEFLUDARABINECHEMBL:CHEMBL19954CHEMBL:CHEMBL600908CHEMBL:CHEMBL600334VANOXERINECHEMBL:CHEMBL598903METHOPRENEDEBRISOQUIN SULFATECATECHOLPANTOPRAZOLE SODIUMBUPROFEZINQUINOXYFENLINOLEIC ACIDALPHA-ENDOSULFANKAVAINCHEMBL:CHEMBL600306METHYCLOTHIAZIDEDIMETHENAMID2,4-DIHYDROXYBENZOPHENONEMEPANIPYRIMBROMOCRIPTINECYTOPROTECTIVE AGENTMETHYLPREDNISOLONECHEMBL:CHEMBL606167ALDRINHAPLAMINECHEMBL:CHEMBL598270CHEMBL:CHEMBL527585PROROXAN HYDROCHLORIDECHLOROPHACINONEDIBUTYLDICHLOROSTANNANEARTEANNUIN BMALATHION6-CHLOROFLAVONECHEMBL:CHEMBL602383CHEMBL:CHEMBL3203612,4-HEXADIENALTEROXIRONECOUMESTROLP-TOLUENESULFONAMIDEKRESOXIM-METHYLPROPICONAZOLEDISULFIRAMCHOLESTEROLTOPOTECAN HYDROCHLORIDECHEMBL:CHEMBL599100PAMICOGRELCHEMBL:CHEMBL259865MERCURIC CHLORIDELEFLUNOMIDECHEMBL:CHEMBL607140CHEMBL:CHEMBL578512BROMAMINIC ACIDQUINIZARINLITHIUMCHEMBL:CHEMBL184450FLUMAZENILCLIOQUINOLSUFORAPHANE ISOSELENOCYANATE4-CHLOROMERCURIBENZOIC ACIDFIPRONILPYRACLOSTROBINCHEMBL:CHEMBL6018229-AMINOCAMPTOTHECINFLUORANTHENEPHENAZINE-1-CARBOXYLIC ACID2-AMINOANTHRACENEMORNIFLUMATECHEMBL:CHEMBL582081RHEINWHILE OLIVETOLFURAZABOLCHEMBL:CHEMBL585502TECTOQUINONEALOE-EMODINDIMETHISTERONEYANGONINHOMIDIUM BROMIDENIFEDIPINEOXADIAZONCHEMBL:CHEMBL443436CHEMBL:CHEMBL590184LANSOPRAZOLENALEDCHEMBL:CHEMBL443343CHEMBL:CHEMBL127579PHENYLALANINECHEMBL:CHEMBL166112STANOLONEGUANFACINE HYDROCHLORIDEBUTACHLORDIBROMOACETIC ACIDCHEMBL:CHEMBL584458DILAZEPCEPHALOCHROMINMEDROXYPROGESTERONE ACETATECOLCHICINEBROMOCRIPTINE MESYLATECHEMBL:CHEMBL591876CHEMBL:CHEMBL156959DICHLORVOSBENZETHONIUM CHLORIDE2-NITROFLUORENECHEMBL:CHEMBL528647CISPLATINWORTMANNINOCTABENZONEDICHLORODIMETHYLSTANNANECHEMBL:CHEMBL577662TRETAZICARTAZAROTENEMETOLACHORCHEMBL:CHEMBL582073CHEMBL:CHEMBL589711CHEMBL:CHEMBL220845TRIBUTYLCHLOROSTANNANECHEMBL:CHEMBL585240CHEMBL:CHEMBL581574DIPHENADIONELAGASCATRIOLPROPYL GALLATEOUABAINCHEMBL:CHEMBL585656DINOSEBLIPOIC ACID, ALPHAPROTEIN PHOSPHATASE INHIBITORFGF-1CHEMBL:CHEMBL583584METHIOCARBTHIOGUANINEPRAZEPAMDIGOXIGENINCYCLOSPORINEACETOCHLORDIGITOXIGENINSULFORAPHANEPENTAMIDINE ISETHIONATEEUFLAVINEDIETHYLSTILBESTROLBERBERINE CHLORIDEEFAVIRENZCHEMBL:CHEMBL584442OMEPRAZOLECHEMBL:CHEMBL578944DANTHRONIOBENGUANEAZINPHOS-ETHYLPINAFIDEMETHOTREXATEPYROGALLOLCHLOROPHENOTHANETRICLOFENOLBENZO[B]TRIPHENYLENEALDICARBISOFLUPREDONE ACETATEPHENYLPYRUVATESU9516DESOXIMETASONECHEMBL:CHEMBL168075BORTEZOMIBNITROMIDEDICHLONANETHOLE TRITHIONEPYRITHIONE SODIUMFENBUCONAZOLECHEMBL:CHEMBL591412DEXAMETHASONE SODIUM PHOSPHATECALCIMYCINEMODINETHYNODIOL DIACETATEBIFENAZATETOSUFLOXACIN TOSYLATEPIFEXOLEACAMPROSATE CALCIUMDICYCLOHEXYLCARBODIIMIDECELECOXIBGAMMA-CYHALOTHRINAROMATICINCHEMBL:CHEMBL581872PHENOXYCARBMONOBENZONEINDOMETHACINDEXTRAN SULFATE SODIUMSAPANISERTIBNONSTEROIDAL ANTIINFLAMMATORY DRUGCHEMBL:CHEMBL482050CARBARILFLUTAMIDE1-HYDROXY-4-ETHOXYBENZENECHEMBL:CHEMBL584883THIORPHAN2,4-DINITROPHENOLCHEMBL:CHEMBL583351CHEMBL:CHEMBL590706CLADRIBINELINTITRIPTFLUOXASTROBINFURAZOLIDONEMETOPRINEBROMODIOLONECHRYSINCARBOQUONEDIBUCAINE HYDROCHLORIDECHLOROTRIPHENYLSTANNANEDIACETYLRHEINNITROFURAZONENORGESTREL5,7-DIHYDROXY-4-METHYLCOUMARINNELFINAVIR MESYLATECHEMBL:CHEMBL528390KINETIN RIBOSIDEDEHYDROEPIANDROSTERONE ACETATECHEMBL:CHEMBL138061BLEOMYCINNAPHTHOQUINONEMOLINATE4-AMINOPHENOLCYPRODINIL5-FLUOROURIDINEGLUTARALCHEMBL:CHEMBL87568BENZYL ISOTHIOCYANATESTROPHANTHIDINCYCLOFENILMETHYLPREDNISOLONE ACETATEMELENGESTROL ACETATEISOFENPHOS2'-HYDROXYCHALCONEDOPAMINECHEMBL:CHEMBL584635CHLORDANEBIOALLETHRIN S-CYCLOPENTENYL ISOMERNANDROLONE DECANOATEOXYMETHOLONECHEMBL:CHEMBL598263DINITRO CRESOLTHIAMINEGW0742XFOSPIRATECHEMBL:CHEMBL591178CHEMBL:CHEMBL269881NITAZOXANIDERECOMBINANT CYTOKINEPROCHLORPERAZINE3-METHYLCHOLANTHRENEBECLOMETHASONECHEMBL:CHEMBL596839CHEMBL:CHEMBL587389CHEMBL:CHEMBL530291CHOLECALCIFEROLDICHLOROPHENCHEMBL:CHEMBL733801-NITROPYRENEFENPYROXYMATEPREGNENOLONE-16&ALPHA-CARBONITRILEFLUMETHASONE PIVALATECHEMBL:CHEMBL533388EPINEPHRINEDAZOMETPROPARGITE2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEPTANOIC ACID [1-(2-HYDROXYMETHYL-PYRROLIDINE-1-CARBONYL)-2-METHYL-PROPYL]-AMIDECHEMBL:CHEMBL600313MEDRYSONECHLOROACETIC ACIDSTANOZOLOLRESACTIN ADIMETHYL FUMARATEMETHYLEUGENOLIODOFORMCHEMBL:CHEMBL578504PHENOTHIAZINEOXYQUINOLINE SULFATENEPAPRAZOLE13-CIS-RETINALCHEMBL:CHEMBL536599CINOBUFOTALINCHEMBL:CHEMBL42355ASCORBIC ACIDHARMINE HYDROCHLORIDELONIDAMINE2-ACETYLAMINOFLUORENETRIS(2,3-DIBROMOPROPYL)PHOSPHATECHEMBL:CHEMBL4439492-BROMOETHANOLSTIROFOSOMAVELOXOLONE2-MERCAPTOBENZOTHIAZOLECHRYSOPHANOLCHEMBL:CHEMBL591630PROGESTERONEBETANAPHTHOLPIOGLITAZONE HYDROCHLORIDEMELPHALANPIPOXOLAN HYDROCHLORIDECHLORPYRIFOSCHEMBL:CHEMBL609570CHEMBL:CHEMBL609438NITROGEN MUSTARD HN-3CHEMBL:CHEMBL591361CHEMBL:CHEMBL1729881,10-PHENANTHROLINEDIBENZOYLMETHANECHEMBL:CHEMBL580727CHEMBL:CHEMBL528181CHLOROXYLENOLCHEMOPREVENTIVE AGENTCHEMBL:CHEMBL599102CHEMBL:CHEMBL13630339,10-PHENANTHRENEQUINONECHEMBL:CHEMBL224318THIRAMRO 40-6055METHABENZTHIAZURONCHEMBL:CHEMBL388979CHEMBL:CHEMBL580918CARFENTRAZONE-ETHYLCHEMBL:CHEMBL388823PHENAZINECHEMBL:CHEMBL592305ANISOMYCINLINOLENIC ACIDPHENOXYBENZAMINE HYDROCHLORIDECHEMBL:CHEMBL538965PAPAVERINE HYDROCHLORIDEINDIGOE319ROSIGLITAZONEPYRAFLUFEN-ETHYLDEXAMETHASONEPENTACHLOROPHENOLAZATHIOPRINECHEMBL:CHEMBL585439IPCONAZOLECHEMBL:CHEMBL577660ROCAGLAMIDECHEMBL:CHEMBL587229CHEMBL:CHEMBL29878QUESTIOMYCIN BBENZOTHIAZYL DISULFIDEVITAMIN AINDOLE-3-CARBINOLCHEMBL:CHEMBL601146CHEMBL:CHEMBL1362503CHEMBL:CHEMBL297304ROTENONECHEMBL:CHEMBL53738LYCOPENECLOXYQUINBENZO[B]FLUORANTHENETRETINOIN7-BENZYLOXYCOUMARINKETOCONAZOLEPERUVOSIDECHEMBL:CHEMBL533226DROMETRIZOLELANATOSIDE CNISOLDIPINECHEMBL:CHEMBL578502CHEMBL:CHEMBL1481509NITRILOTRIACETIC ACIDFINASTERIDECHEMBL:CHEMBL295337BETAMETHASONECHEMBL:CHEMBL591631NOVIFLUMURONALPHA-TERTHIENYLCHRYSENEALPHA-PHELLANDRENECHEMBL:CHEMBL253989STREPTONIGRINTRITON XENDOSULFANCHEMBL:CHEMBL398363TENATOPRAZOLECHEMBL:CHEMBL1531222PHENAZOPYRIDINE HYDROCHLORIDEPELUBIPROFENTETRAZOLIUM REDS-METOLACHLORHYDROQUINONESAQUINAVIR MESYLATEISOPROPYL PALMITATECHEMBL:CHEMBL529138GENE TRANSDUCTION AGENTCHEMBL:CHEMBL586135TRIFLOXYSTROBINAZAMETHIPHOSPREGNENOLONESOFALCONETCDDGENISTEINCHEMBL:CHEMBL578915PIRITREXIM ISETHIONATETHIOCYCLAM HYDROGEN OXALATESORAFENIB(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEATOVAQUONEDAIDZEINPD-169316PHENYTOIN SODIUMKAEMPHEROLARISTOLOCHIC ACIDTUBERCIDINMETHYLTHIONINIUM CHLORIDECHEMBL:CHEMBL118417CARFILZOMIBCETYLPYRIDINIUM BROMIDEMETHYL ALCOHOLMETHYL ABIETATEZAFIRLUKASTCHEMBL:CHEMBL22062HYDROCORTISONE HEMISUCCINATENITROFENBIPHENYLDEXBUDESONIDEIOPANOIC ACIDAMINOCARBCALCIPOTRIENECHEMBL:CHEMBL547977MIFEPRISTONEJNJ1661010HELENALINETODOLACLIOTHYRONINE SODIUMESTRADIOL VALERATEFUMAGILLINCHEMBL:CHEMBL555242CHEMBL:CHEMBL254077TYRPHOSTIN A9APIGENIN(S)-ROSCOVITINETHIOINOSINEBUMETANIDEBROMOXYNILCHEMBL:CHEMBL600971DIGOXINPYRIPROXYFENHYDROCORTISONE ACETATECHEMBL:CHEMBL530361(1R)-TRANS-TETRAMETHRINCHEMBL:CHEMBL1873684PREDNISOLONE SODIUM SUCCINATEALLO-OCIMENECHLORMIDAZOLELEAD DIACETATE TRIHYDRATEMITOTANEPHOSALONEHARMINEOXYQUINOLINEMETHYL YELLOWRESVERATROLHPTEHYPERICINCHEMBL:CHEMBL529918PHENFORMIN HYDROCHLORIDECHLORANILMORICIZINE HYDROCHLORIDECRUFOMATELEVOTHYROXINETRIBUTYLTIN-OXIDECHEMBL:CHEMBL84685INDIUM CHLORIDECHEMBL:CHEMBL582030TEMEFOSRETINYL ACETATECHEMBL:CHEMBL585591TOLFENAMIC ACIDAZOXYSTROBINCHEMBL:CHEMBL261692METACRESOLCHEMBL:CHEMBL128729CADMIUM DICHLORIDEPYRAZOLESIMVASTATINCHEMBL:CHEMBL1990783CHEMBL:CHEMBL275260SUFENTANIL CITRATEHYDROXYFLUTAMIDECHEMBL:CHEMBL602424CHEMBL:CHEMBL597035ROSIGLITAZONE MALEATE
Interaction Protein
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
Interaction Count
38
Interaction Dataset
intact_biogrid