Protein detail

GRIK5

Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)

Entry name GRIK5	UniProt ID Q16478	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 3	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Glutamate receptor ionotropic, kainate 5 (GluK5) (Excitatory amino acid receptor 2) (EAA2) (Glutamate receptor KA-2) (KA2)

Protein Function (2)

Transporters:Transporter channels and pores
FDA approved drug targets:Small molecule drugs

Transmembrane

545..565; Helical; 623..643; Helical; 804..824; Helical

Transmembrane Count

Ensembl

ENSG00000105737

Entrez Gene Symbol

GRIK5

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway8

Protein Function (2)

Transporters:Transporter channels and pores
FDA approved drug targets:Small molecule drugs

Cellular Component (8)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (5)

Canonical Pathways

M17 Pid notch pathway

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence37

Ligand-Receptor Signaling (35)

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No
receptor	receptor	CellCellInteractions	No	Yes	No	No	No
glutamate_ionotropic	receptor	HGNC	No	Yes	No	No	No
receptor	receptor	HGNC	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Glutamate_Kainate_2_5_complex	GRIK2 GRIK5	Q13002 Q16478	1:1	CellPhoneDBCellChatDBComplexPortal	CellPhoneDB:Glutamate_Kainate_2_5_complex	14755292 34706237

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blottingELISA	7	39290459 28242843 37926697 37686366 40098346 41201090 40311616

Sequence, Structure & Domains9

Sequences

Length

980

Mass

109,265

Sequence

MPAELLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTRRSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELAEHE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16478-1; Sequence=Displayed; Name=2; IsoId=Q16478-2; Sequence=VSP_035585

Alternative Sequence

839..980; VSVCQEMLQELRHAVSCRKTSRSRRRRRPGGPSRALLSLRAVREMRLSNGKLYSAGAGGDAGSAHGGPQRLLDDPGPPSGARPAAPTPCTHVRVCQECRRIQALRASGAGAPPRGLGVPAEATSPPRPRPGPAGPRELAEHE -> TPALHPAACQCSALGPRTPLKEPSMLLVKVPSTRVQVAFSRTSLRQVCPFLLQHQLSSLYWIQATNVQICCHFSSLKPSPDLTFPPSHRPLSSLLFTALAAVGGLPDASSFFFPPISSCPPLQSGIGPCHSTEATLVTSNFHV (in isoform 2)

Domain & Motif Annotations

Compositional Bias

894..903; Gly residues

Region

891..927; Disordered; 944..980; Disordered

Protein Families (2)

Glutamate-gated ion channel (TC 1.A.10.1) family
GRIK5 subfamily

Sequence Similarities

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily.

Clinical Relevance1

Drugs (10)

TEZAMPANEL ZIRITAXESTAT X-165 TOPIRAMATE EXAMPLE 1.11 [WO2014139978]BIO-32546 PF-8380 BI-2545 SELURAMPANEL EXAMPLE 2 [WO2013054185]

Supporting Publications2

PMID	Title	Abstract
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available