Protein detail
SGCB
Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b)
Entry name SGCB | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b)
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
66..86; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
A3bLGMD2ESGC
Gene Description
Sarcoglycan beta
Chromosome
4
Position
52020706-52038299
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificseminal vesicleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificpericyte
Function & Pathway
Protein Function (2)
- Disease related genes
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (6)
Molecular Function
Biological Process (3)
KEGG (5)
Reactome (3)
Canonical Pathways (3)
- M190 Pid tcr jnk pathway
- M206 Pid pdgfra pathway
- M274 Pid lymph angiogenesis pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | LOCATE | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | UniProt_location | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| sarcoglycan | matrix_adhesion | Almen2009 | Yes | Yes | |||
| adhesion | adhesion | OmniPath | Yes | Yes | Yes | ||
| matrix_adhesion | matrix_adhesion | OmniPath | Yes | Yes | |||
| transmembrane | transmembrane | UniProt_location | Yes |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
318
Mass
34,777
Sequence
MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16585-1; Sequence=Displayed; Name=2; IsoId=Q16585-2; Sequence=VSP_056894
Alternative Sequence
12..81; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
21..32; Basic and acidic residues
Region
1..32; Disordered
Protein Families
Sarcoglycan beta/delta/gamma/zeta family
Sequence Similarities
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Clinical Relevance
Disease Involvement (2)
Disease variantLimb-girdle muscular dystrophy
Related Diseases (2)
Biomarker
Phase 1/2
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 28211531 | Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer. | No related sentences available |
| 31414377 | Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. | No related sentences available |