Protein detail
SGCB
Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b)
Entry name SGCB | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Beta-sarcoglycan (Beta-SG) (43 kDa dystrophin-associated glycoprotein) (43DAG) (A3b)
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Transmembrane
66..86; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
A3bLGMD2ESGC
Gene Description
Sarcoglycan beta
Chromosome
4
Position
52020706-52038299
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization4
Tissue Specificseminal vesicleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificpericyte
Function & Pathway8
Protein Function (2)
- Disease related genes
- Human disease related genes:Musculoskeletal diseases:Muscular diseases
Cellular Component (6)
Molecular Function
Biological Process (3)
KEGG (5)
Reactome (3)
Canonical Pathways (3)
- M190 Pid tcr jnk pathway
- M206 Pid pdgfra pathway
- M274 Pid lymph angiogenesis pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence29
Ligand-Receptor Signaling (27)
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| sarcoglycan | matrix_adhesion | Almen2009 | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
Page 1 of 3Next
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains9
Sequences
Length
318
Mass
34,777
Sequence
MAAAAAAAAEQQSSNGPVKKSMREKAVERRSVNKEHNSNFKAGYIPIDEDRLHKTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGLLRFKQVSDMGVIHPLYKSTVGGRRNENLVITGNNQPIVFQQGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGVKSLNVQKASTERITSNATSDLNIKVDGRAIVRGNEGVFIMGKTIEFHMGGNMELKAENSIILNGSVMVSTTRLPSSSSGDQLGSGDWVRYKLCMCADGTLFKVQVTSQNMGCQISDNPCGNTH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16585-1; Sequence=Displayed; Name=2; IsoId=Q16585-2; Sequence=VSP_056894
Alternative Sequence
12..81; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
21..32; Basic and acidic residues
Region
1..32; Disordered
Protein Families
Sarcoglycan beta/delta/gamma/zeta family
Sequence Similarities
Belongs to the sarcoglycan beta/delta/gamma/zeta family.
Clinical Relevance4
Disease Involvement (2)
Disease variantLimb-girdle muscular dystrophy
Related Diseases
Biomarker
Phase 1/2
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 28211531 | Proteomic analysis of urinary extracellular vesicles from high Gleason score prostate cancer. | No abstract available |
| 31414377 | Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics. | No abstract available |