Protein detail
CALRL
Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (CRLR)
Protein symbol CALRL | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 7 | Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) (CRLR)
Protein Class
Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- G-protein coupled receptors:Family 2 (B) receptors
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
140..164; Helical; Name=1; 176..198; Helical; Name=2; 210..238; Helical; Name=3; 253..273; Helical; Name=4; 290..314; Helical; Name=5; 330..351; Helical; Name=6; 367..387; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CGRPRCRLR
Gene Description
Calcitonin receptor like receptor
Chromosome
2
Position
187341964-187448460
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificLate spermatidsSingle-Nuclei Brain Specificoligodendrocyte
Function & Pathway
Protein Function
- G-protein coupled receptors:Family 2 (B) receptors
- Transporters
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-419812 calcitonin like ligand receptors
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-373080 class b 2 secretin family receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418555 g alpha s signalling events
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-372790 signaling by gpcr
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
54 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CRLR-RAMP1 complex | CALCRLRAMP1 | O60894Q16602 | 4:4 | Guide2PharmaCellPhoneDBICELLNETComplexPortalCORUMCompleatPDB | PDB:3n7pPDB:7kntPDB:6umgPDB:3n7rCellPhoneDB:RAMP1_complexCORUM:1300PDB:3n7sCompleat:HC276intact:EBI-9009008 | 1536134311693189962079724115156216496451868741614755292113873281153560621658025 |
| CRLR-RAMP2 complex | CALCRLRAMP2 | O60895Q16602 | 1:1 | Guide2PharmaCellPhoneDBICELLNETComplexPortalCORUMCompleatPDB | intact:EBI-9009036Compleat:HC3564CellPhoneDB:RAMP2_complexCORUM:3140PDB:3aqf | 15361343116931892905947396207972411515621649645186874161475529211387328 |
| CALCACALCRLRAMP1 | O60894P06881Q16602 | 1:1:1 | PDB | PDB:7knu | ||
| ADMCALCRL | P35318Q16602 | 4:4 | PDB | PDB:5v6yPDB:6v2ePDB:4rwf | ||
| CALCRL | Q16602 | 3 | PDB | PDB:4rwg | ||
| ADM2CALCRL | Q16602Q7Z4H4 | 3:3 | PDB | PDB:6d1u |
Sequence, Structure & Domains
Sequences
Length
461
Mass
52,979
Sequence
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQAEGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSASYTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
3D Structural Models
Turn
107..109; 115..117; 131..133; 198..200; 202..204; 261..263; 385..387; 399..401
Helix
35..54; 125..128; 134..143; 148..165; 172..197; 205..207; 211..241; 253..260; 264..276; 281..283; 289..291; 292..320; 331..345; 347..349; 364..384; 389..398
Beta Strand
60..62; 63..65; 71..75; 77..79; 82..87; 90..92; 99..105; 118..120; 244..246; 350..352
3D Structure
Electron microscopy (6); X-ray crystallography (17)
Domain & Motif Annotations
Region
288..289; Required for RAMP3 interaction
Protein Families
G-protein coupled receptor 2 family
Sequence Similarities
Belongs to the G-protein coupled receptor 2 family.
Clinical Relevance
Disease Involvement
Disease variantFDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
Interaction Protein
ENSG00000132329
Interaction Count
1
Interaction Dataset
intact_biogrid