Protein detail

NTRK2

BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)

Entry name NTRK2	UniProt ID Q16620	EVMP confidence score 0.38
Supporting publications (n) 3	Transmembrane count 1	Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)

Protein Class (10)

Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters

Protein Function (11)

Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
ENZYME proteins:Transferases
Human disease related genes:Nervous system diseases:Epilepsy
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport
Kinases:Tyr protein kinases
Disease related genes

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Transmembrane

431..454; Helical

Transmembrane Count

Ensembl

ENSG00000148053

Entrez Gene Symbol

NTRK2

Gene Synonym

TRKB

Gene Description

Neurotrophic receptor tyrosine kinase 2

Chromosome

Position

84668375-85095751

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway7

Protein Function (11)

Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
ENZYME proteins:Transferases
Human disease related genes:Nervous system diseases:Epilepsy
RAS pathway related proteins
Enzymes
Cancer-related genes:Candidate cancer biomarkers
Transporters:Accessory Factors Involved in Transport
Kinases:Tyr protein kinases
Disease related genes

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Cellular Component (12)

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Molecular Function (7)

Biological Process (3)

KEGG (6)

Reactome (16)

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Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence75

Enzyme-Mediated Modification (11)

11 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NTRK2	PTPN1	P18031	Y	706	dephosphorylation	SIGNOR	SIGNOR:26214522
NTRK2	PTPN1	P18031	Y	707	dephosphorylation	SIGNOR	SIGNOR:26214522
NTRK2	SRC	P12931	Y	707	phosphorylation	Reactome_ProtMapperProtMapper
NTRK2	SRC	P12931	Y	706	phosphorylation	Reactome_ProtMapperProtMapper
NTRK2	FYN	P06241	Y	707	phosphorylation	Reactome_ProtMapperProtMapper
NTRK2	FYN	P06241	Y	706	phosphorylation	Reactome_ProtMapperProtMapper
NTRK2	AKAP4	Q5JQC9	Y	516	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26839918
NTRK2	BDNF	P23560	Y	516	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:28679669 ProtMapper:21849472 ProtMapper:26899129
NTRK2	BDNF	P23560	Y	817	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26740873
NTRK2	CDK5	Q00535	S	479	phosphorylation	KEA	KEA:17341134

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Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No

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Regulatory Interaction Network (11)

11 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
BDNF	P23560	NTRK2	Q16620	Yes	Yes	No	iTALKSIGNORProtMapperHINTSignaLink3UniProt_LRdbDIPLit-BM-17HPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007CA1Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBioGRIDBaccin2019CellinkerREACH_ProtMapperSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbSparser_ProtMapperHPMR_CellinkerconnectomeDB2020AlzPathwayLRdb	HINT:9312147 connectomeDB2020:7644540 LRdb:7644540Baccin2019:76445409312147ProtMapper:26899129 HINT:21651720 CA1:9648856 CA1:1645620 ProtMapper:28679669 Lit-BM-17:9312147 connectomeDB2020:9312147 ProtMapper:33606976 Cellinker:9312147 CellChatDB:27908981 HPMR:7644540 BioGRID:9312147 ProtMapper:21849472 AlzPathway:9775403 Cellinker:27908981 ProtMapper:26740873LRdb:931SignaLink3:9312147 Cellinker:7644540 SignaLink3:23331499 HPRD:9312147 DIP:9312147 SIGNOR:7679912 Lit-BM-17:21651720 CellTalkDB:7644540 Lit-BM-17:11855816 HINT:11855816 BioGRID:21651720
NTRK2	Q16620	FYN	P06241	Yes	Yes	No	WangSIGNORProtMapperHPRDCui2007SignaLink3CA1SPIKE_LCREACH_ProtMapper	SignaLink3:9648856 SIGNOR:9648856 ProtMapper:26252487 HPRD:9648856 SPIKE_LC:16713569 SignaLink3:23331499 CA1:9648856
SQSTM	Q13501	NTRK2	Q16620	Yes	Yes	No	HPRDSignaLink3	SignaLink3:12471037 SignaLink3:18457658 SignaLink3:23331499 HPRD:12471037
NTRK2	Q16620	SHC3	Q92529	Yes	Yes	No	PhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointSIGNORiPTMnetHPRDSignaLink3BioGRIDWangLit-BM-17PhosphoSite	PhosphoSite:16126371 BioGRID:19166614 SIGNOR:11791173 SignaLink3:9507002 SignaLink3:23331499 HPRD:9507002 Lit-BM-17:12074588 SIGNOR:9507002 Lit-BM-17:9507002
NTRK2	Q16620	NCK2	O43639	Yes	Yes	No	PhosphoPointSIGNORHPRDSignaLink3SPIKE_LCLit-BM-17	SIGNOR:12074588 SignaLink3:12074588 SPIKE_LC:16713569 HPRD:12074588 Lit-BM-17:12074588 SignaLink3:23331499
NTRK2	Q16620	KCNA3	P22001	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:19166614 ProtMapper:19166614 SIGNOR:19166614 PhosphoSite:11812778 PhosphoSite:26655221
NTRK2	Q16620	PLCG1	P19174	Yes	Yes	No	PhosphoPointSIGNORHPRDHINTPhosphoSite_KEAKEAWangLit-BM-17	KEA:7682059 HINT:10092678 Lit-BM-17:10092678 KEA:15144186 KEA:1708307 KEA:8657103 KEA:1689310 HINT:12074588 KEA:16126727 KEA:17081983 HPRD:12419535 KEA:15592455 SIGNOR:20445044 KEA:16153436 Lit-BM-17:12074588 KEA:8885868 KEA:16038803 KEA:12601080
NTF4	P34130	NTRK2	Q16620	Yes	Yes	No	iTALKSIGNORHINTUniProt_LRdbLit-BM-17HPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020AlzPathwayLRdb	HINT:11855816LRdb:119Lit-BM-17:11738045 connectomeDB2020:7679912 connectomeDB2020:11855816 AlzPathway:9775403 Cellinker:27908981Baccin2019:767991211855816CellTalkDB:7679912 Cellinker:11855816 SIGNOR:7679912 HINT:29997244 Lit-BM-17:25241761 HPRD:11855816 Cellinker:7679912 Lit-BM-17:11855816 HINT:11738045 CellChatDB:27908981 LRdb:7679912
PTN1	P18031	NTRK2	Q16620	Yes	No	Yes	SIGNORProtMapperHPRDBioGRIDInnateDBSIGNOR_ProtMapper	BioGRID:25288805 ProtMapper:26214522 InnateDB:12237455 HPRD:12237455 SIGNOR:26214522
PTN11	Q06124	NTRK2	Q16620	Yes	No	Yes	HPRDSIGNOR	SIGNOR:28947394 HPRD:10386953

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	NTF4 NTRK2	P34130 Q16620	2:2	PDB	PDB:1hcf
	NTRK2	Q16620	2	PDB	PDB:8oyd

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	28211531 31718609

Sequence, Structure & Domains15

Sequences

Length

822

Mass

91,999

Sequence

MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG

Alternative Products

Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=TrkB; Synonyms=gp145-TrkB; IsoId=Q16620-1; Sequence=Displayed; Name=TrkB-T1; IsoId=Q16620-2; Sequence=VSP_002901, VSP_002902; Name=TrkB-T-Shc; IsoId=Q16620-3; Sequence=VSP_002903, VSP_002904; Name=4; IsoId=Q16620-4; Sequence=VSP_041942; Name=5; IsoId=Q16620-5; Sequence=VSP_041942, VSP_002903, VSP_002904; Name=TrkB-T-TK; IsoId=Q16620-6; Sequence=VSP_042178, VSP_042179; Name=TrkB-N-T1; IsoId=Q16620-7; Sequence=VSP_042177, VSP_002901, VSP_002902

Alternative Sequence

1..156; Missing (in isoform TrkB-N-T1); 465; K -> KDFSWFGFGKVKSRQGV (in isoform 4 and isoform 5); 467..477; PASVISNDDDS -> FVLFHKIPLDG (in isoform TrkB-T1 and isoform TrkB-N-T1); 478..822; Missing (in isoform TrkB-T1 and isoform TrkB-N-T1); 529..537; FVQHIKRHN -> WPRGSPKTA (in isoform TrkB-T-Shc and isoform 5); 538..822; Missing (in isoform TrkB-T-Shc and isoform 5); 710..735; GGHTMLPIRWMPPESIMYRKFTTESD -> SSCADQRPQGPLSLRDPCCICLLRLS (in isoform TrkB-T-TK); 736..822; Missing (in isoform TrkB-T-TK)

3D Structural Models

Turn

515..517; 710..712; 748..750; 753..756

Helix

353..355; 428..460; 535..537; 579..592; 625..631; 634..638; 650..669; 679..681; 686..688; 698..701; 703..705; 717..719; 722..727; 732..747; 759..768; 780..789; 794..796; 800..813

Beta Strand

285..292; 300..308; 314..319; 322..324; 328..337; 339..350; 357..364; 369..376; 380..382; 462..464; 500..503; 506..512; 538..545; 552..557; 567..574; 603..607; 609..618; 641..643; 682..684; 690..692; 707..709; 713..715

3D Structure

NMR spectroscopy (2); X-ray crystallography (7)

Domain & Motif Annotations

Compositional Bias

485..495; Polar residues

Repeat

92..113; LRR 1; 116..137; LRR 2

Domain (FT)

32..61; LRRNT; 148..196; LRRCT; 197..282; Ig-like C2-type 1; 295..365; Ig-like C2-type 2; 538..807; Protein kinase

Region

455..466; Interaction with MAPK8IP3/JIP3; 475..498; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
Insulin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Clinical Relevance7

Disease Involvement (5)

Cancer-related genesDisease variantEpilepsyFDA approved drug targetsObesity

Drug Targets

FDA approved drug targets

Antibody (3)

HPA007637 CAB010346 HPA074873

Interaction Protein (2)

ENSG00000140538ENSG00000146648

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications3

PMID	Title	Abstract
37862381	Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available