Protein detail
NTRK2
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Entry name NTRK2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Protein Class (10)
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteinsRAS pathway related proteinsTransporters
Protein Function (11)
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Nervous system diseases:Epilepsy
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
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Transmembrane
431..454; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
TRKB
Gene Description
Neurotrophic receptor tyrosine kinase 2
Chromosome
9
Position
84668375-85095751
Supporting publications (n)
3
EVMP confidence score
0.38
Fluorescence & Localization1
Function & Pathway7
Protein Function (11)
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Nervous system diseases:Epilepsy
- RAS pathway related proteins
- Enzymes
- Cancer-related genes:Candidate cancer biomarkers
- Transporters:Accessory Factors Involved in Transport
- Kinases:Tyr protein kinases
- Disease related genes
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Cellular Component (12)
- GO:0005769 early endosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0014069 postsynaptic density
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0031901 early endosome membrane
- GO:0043195 terminal bouton
- GO:0043197 dendritic spine
- GO:0043235 receptor complex
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Molecular Function (7)
Biological Process (3)
KEGG (6)
Reactome (16)
- R-hsa-9032845 activated ntrk2 signals through cdk5
- R-hsa-9028731 activated ntrk2 signals through frs2 and frs3
- R-hsa-9032500 activated ntrk2 signals through fyn
- R-hsa-9028335 activated ntrk2 signals through pi3k
- R-hsa-9026519 activated ntrk2 signals through ras
- R-hsa-187015 activation of trka receptors
- R-hsa-2219530 constitutive signaling by aberrant pi3k in cancer
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9006925 intracellular signaling by second messengers
- R-hsa-199418 negative regulation of the pi3k akt network
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Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence75
Enzyme-Mediated Modification (11)
11 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| NTRK2 | PTPN1 | P18031 | Y | 706 | dephosphorylation | SIGNOR | SIGNOR:26214522 |
| NTRK2 | PTPN1 | P18031 | Y | 707 | dephosphorylation | SIGNOR | SIGNOR:26214522 |
| NTRK2 | SRC | P12931 | Y | 707 | phosphorylation | Reactome_ProtMapperProtMapper | |
| NTRK2 | SRC | P12931 | Y | 706 | phosphorylation | Reactome_ProtMapperProtMapper | |
| NTRK2 | FYN | P06241 | Y | 707 | phosphorylation | Reactome_ProtMapperProtMapper | |
| NTRK2 | FYN | P06241 | Y | 706 | phosphorylation | Reactome_ProtMapperProtMapper | |
| NTRK2 | AKAP4 | Q5JQC9 | Y | 516 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26839918 |
| NTRK2 | BDNF | P23560 | Y | 516 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:28679669ProtMapper:21849472ProtMapper:26899129 |
| NTRK2 | BDNF | P23560 | Y | 817 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26740873 |
| NTRK2 | CDK5 | Q00535 | S | 479 | phosphorylation | KEA | KEA:17341134 |
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Ligand-Receptor Signaling (50)
50 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | CellCall | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| receptor | receptor | EMBRACE | No | Yes | No | Yes | No |
| tyrosine_kinase | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network (11)
11 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| NTRK2 | Q16620 | FRS3 | O43559 | Yes | Yes | No | WangMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEASIGNOR_ProtMapper | HPRD:11432792SIGNOR:11432792ProtMapper:11432792KEA:11432792 |
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Protein Complex Composition (2)
Sequence, Structure & Domains15
Sequences
Length
822
Mass
91,999
Sequence
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Alternative Products
Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist.; Name=TrkB; Synonyms=gp145-TrkB; IsoId=Q16620-1; Sequence=Displayed; Name=TrkB-T1; IsoId=Q16620-2; Sequence=VSP_002901, VSP_002902; Name=TrkB-T-Shc; IsoId=Q16620-3; Sequence=VSP_002903, VSP_002904; Name=4; IsoId=Q16620-4; Sequence=VSP_041942; Name=5; IsoId=Q16620-5; Sequence=VSP_041942, VSP_002903, VSP_002904; Name=TrkB-T-TK; IsoId=Q16620-6; Sequence=VSP_042178, VSP_042179; Name=TrkB-N-T1; IsoId=Q16620-7; Sequence=VSP_042177, VSP_002901, VSP_002902
Alternative Sequence
1..156; Missing (in isoform TrkB-N-T1); 465; K -> KDFSWFGFGKVKSRQGV (in isoform 4 and isoform 5); 467..477; PASVISNDDDS -> FVLFHKIPLDG (in isoform TrkB-T1 and isoform TrkB-N-T1); 478..822; Missing (in isoform TrkB-T1 and isoform TrkB-N-T1); 529..537; FVQHIKRHN -> WPRGSPKTA (in isoform TrkB-T-Shc and isoform 5); 538..822; Missing (in isoform TrkB-T-Shc and isoform 5); 710..735; GGHTMLPIRWMPPESIMYRKFTTESD -> SSCADQRPQGPLSLRDPCCICLLRLS (in isoform TrkB-T-TK); 736..822; Missing (in isoform TrkB-T-TK)
3D Structural Models
Turn
515..517; 710..712; 748..750; 753..756
Helix
353..355; 428..460; 535..537; 579..592; 625..631; 634..638; 650..669; 679..681; 686..688; 698..701; 703..705; 717..719; 722..727; 732..747; 759..768; 780..789; 794..796; 800..813
Beta Strand
285..292; 300..308; 314..319; 322..324; 328..337; 339..350; 357..364; 369..376; 380..382; 462..464; 500..503; 506..512; 538..545; 552..557; 567..574; 603..607; 609..618; 641..643; 682..684; 690..692; 707..709; 713..715
3D Structure
NMR spectroscopy (2); X-ray crystallography (7)
Domain & Motif Annotations
Compositional Bias
485..495; Polar residues
Repeat
92..113; LRR 1; 116..137; LRR 2
Domain (FT)
32..61; LRRNT; 148..196; LRRCT; 197..282; Ig-like C2-type 1; 295..365; Ig-like C2-type 2; 538..807; Protein kinase
Region
455..466; Interaction with MAPK8IP3/JIP3; 475..498; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- Insulin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Clinical Relevance7
Disease Involvement (5)
Cancer-related genesDisease variantEpilepsyFDA approved drug targetsObesity
Drug Targets
FDA approved drug targets
Drugs (49)
LAROTRECTINIB SULFATENULLCYCLOSPORINEPILOCARPINE HYDROCHLORIDEGW441756XALISERTIBENTRECTINIBAST-487AZD-7451GAMBOGIC AMIDELESTAURTINIBMK-2461SELITRECTINIBLAROTRECTINIBZM447439CLOZAPINECHEMBL:CHEMBL546797PD-0166285LITHIUMDOXORUBICIN HYDROCHLORIDESP-600125LAUROGUADINEDOVITINIBCENEGERMIN-BKBJDIETHYLDITHIOCARBAMATELINIFANIBALTIRATINIBBMS-754807CISPLATINSB202190CORTICOTROPINDORAMAPIMODCRIZOTINIBAZD-6918SNS-314HESPERADINTAMATINIBTALETRECTINIBILORASERTIBPLX-7486SORAFENIBCEP-2563RG-1530PF-562271CENISERTIBMETHADONE HYDROCHLORIDEGW-2580TOZASERTIBJNJ-7706621
Interaction Protein (2)
ENSG00000140538ENSG00000146648
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37862381 | Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |
| 41216884 | Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. | No abstract available |