Protein detail

DREB

Drebrin (Developmentally-regulated brain protein)

Entry name
DREB
UniProt ID
Q16643
EVMP confidence score
0.53
Supporting publications (n)
4
Transmembrane count
Protein classification
Disease related genesPlasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Drebrin (Developmentally-regulated brain protein)
Protein Class (3)
Disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (2)
  • Disease related genes
  • Predicted intracellular proteins
Ensembl
ENSG00000113758
Entrez Gene Symbol
DBN1
Gene Synonym
D0S117E
Gene Description
Drebrin 1
Chromosome
5
Position
177456608-177474401
Supporting publications (n)
4
EVMP confidence score
0.53
Fluorescence & Localization
Cell SpecificCorticotrophs
Function & Pathway
Protein Function (2)
  • Disease related genes
  • Predicted intracellular proteins
Cellular Component (12)
Page 1 of 2
Molecular Function (4)
Biological Process (3)
Reactome (7)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence17

Enzyme-Mediated Modification (6)

6 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
DBN1CDK5Q00535S142phosphorylationSparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:30467237ProtMapper:24637538ProtMapper:25945928ProtMapper:23979715
DBN1CDK5Q00535S342phosphorylationPhosphoSite
DBN1CDK5Q00535S144phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
DBN1ATMQ13315S647phosphorylationPhosphoSite
DBN1CDK5R1Q15078S142phosphorylationSparser_ProtMapperProtMapperProtMapper:25945928
DBN1CDK1P06493S141phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (7)

7 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATE
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath
gap_junctiongap_junctionGO_IntercellYesYes
gap_junctiongap_junctionOmniPathYesYes

Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
CDK5Q00535DREBQ16643YesYesSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:24637538PhosphoSite:28319065ProtMapper:23979715PhosphoSite:24637538ProtMapper:30467237PhosphoSite:23979715ProtMapper:25945928SIGNOR:23979715PhosphoSite:30467237

Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
DBN1DDX19APOU2F1RABL2ASPTAN1SPTBN1P14859Q01082Q13813Q16643Q9NUU7Q9UBK70:0:0:0:0:0Havugimana2012Havugimana2012:C_509
DBN1ZMYND8Q16643Q9ULU42:2PDBPDB:5y1z

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMass spectrometryWestern blotting738113368333044784018949735399949413079683820710638716512
Sequence, Structure & Domains

Sequences

Length
649
Mass
71,429
Sequence
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Drebrin E, drebrin E2, Embryonic drebrin; IsoId=Q16643-1; Sequence=Displayed; Name=2; IsoId=Q16643-2; Sequence=VSP_028175; Name=3; Synonyms=Drebrin A; IsoId=Q16643-3; Sequence=VSP_053443
Alternative Sequence
4..29; VSFSGHRLELLAAYEEVIREESAADW -> HPWHGTAALASSQAWRDGRERQALVSCR (in isoform 2); 319; G -> GRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPC (in isoform 3)

3D Structural Models

Helix
10..21; 50..54; 55..57; 92..99; 102..108; 121..123; 126..132; 541..543
Beta Strand
23..26; 29..34; 40..49; 62..70; 72..74; 79..86; 114..120
3D Structure
X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
208..236; Basic and acidic residues; 288..298; Basic and acidic residues; 334..348; Polar residues; 363..374; Pro residues; 582..594; Polar residues
Domain (FT)
3..134; ADF-H
Region
208..420; Disordered; 477..502; Disordered; 538..620; Disordered
Clinical Relevance
Disease Involvement (3)
Alzheimer diseaseAmyloidosisNeurodegeneration
Related Diseases (2)
Alzheimer diseaseAmyloidosis
Drugs
GRASSYSTATIN A
Antibody (2)
HPA051452HPA056940
Interaction Protein (3)
ENSG00000077549ENSG00000085733ENSG00000177885
Interaction Count
3
Interaction Dataset (2)
biogrid_opencellintact_biogrid
Supporting Publications4
PMIDTitleRelated sentences
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No related sentences available
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available
38207106Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.No related sentences available
40189497Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.No related sentences available