Protein detail
DREB
Drebrin (Developmentally-regulated brain protein)
Protein symbol DREB | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count | Protein classification Disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Drebrin (Developmentally-regulated brain protein)
Protein Class
Disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
D0S117E
Gene Description
Drebrin 1
Chromosome
5
Position
177456608-177474401
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCorticotrophs
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
- GO:0005737 cytoplasm
- GO:0005856 cytoskeleton
- GO:0005921 gap junction
- GO:0014069 postsynaptic density
- GO:0015629 actin cytoskeleton
- GO:0030425 dendrite
- GO:0030426 growth cone
- GO:0030863 cortical cytoskeleton
- GO:0042641 actomyosin
- GO:0045211 postsynaptic membrane
- GO:0098978 glutamatergic synapse
- GO:0099524 postsynaptic cytosol
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
6 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DBN1 | CDK5 | Q00535 | S | 142 | phosphorylation | Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:30467237ProtMapper:24637538ProtMapper:25945928ProtMapper:23979715 |
| DBN1 | CDK5 | Q00535 | S | 342 | phosphorylation | PhosphoSite | |
| DBN1 | CDK5 | Q00535 | S | 144 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| DBN1 | ATM | Q13315 | S | 647 | phosphorylation | PhosphoSite | |
| DBN1 | CDK5R1 | Q15078 | S | 142 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:25945928 |
| DBN1 | CDK1 | P06493 | S | 141 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| gap_junction | gap_junction | GO_Intercell | Yes | Yes | No | No | No |
| gap_junction | gap_junction | OmniPath | Yes | Yes | No | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CDK5 | Q00535 | DREB | Q16643 | Yes | Yes | No | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:24637538PhosphoSite:28319065ProtMapper:23979715PhosphoSite:24637538ProtMapper:30467237PhosphoSite:23979715ProtMapper:25945928SIGNOR:23979715PhosphoSite:30467237 |
Protein Complex Composition
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
649
Mass
71,429
Sequence
MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Drebrin E, drebrin E2, Embryonic drebrin; IsoId=Q16643-1; Sequence=Displayed; Name=2; IsoId=Q16643-2; Sequence=VSP_028175; Name=3; Synonyms=Drebrin A; IsoId=Q16643-3; Sequence=VSP_053443
Alternative Sequence
4..29; VSFSGHRLELLAAYEEVIREESAADW -> HPWHGTAALASSQAWRDGRERQALVSCR (in isoform 2); 319; G -> GRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPC (in isoform 3)
3D Structural Models
Helix
10..21; 50..54; 55..57; 92..99; 102..108; 121..123; 126..132; 541..543
Beta Strand
23..26; 29..34; 40..49; 62..70; 72..74; 79..86; 114..120
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
208..236; Basic and acidic residues; 288..298; Basic and acidic residues; 334..348; Polar residues; 363..374; Pro residues; 582..594; Polar residues
Domain (FT)
3..134; ADF-H
Region
208..420; Disordered; 477..502; Disordered; 538..620; Disordered
Clinical Relevance
Disease Involvement
Alzheimer diseaseAmyloidosisNeurodegeneration
Drugs
Interaction Protein
ENSG00000077549ENSG00000085733ENSG00000177885
Interaction Count
3
Interaction Dataset
biogrid_opencellintact_biogrid