Protein detail

DREB

Drebrin (Developmentally-regulated brain protein)

Entry name DREB	UniProt ID Q16643	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count	Protein classification Disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Drebrin (Developmentally-regulated brain protein)

Protein Class (3)

Disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000113758

Entrez Gene Symbol

DBN1

Gene Synonym

D0S117E

Gene Description

Drebrin 1

Chromosome

Position

177456608-177474401

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificCorticotrophs

Function & Pathway6

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (12)

Page 1 of 2

Molecular Function (4)

Biological Process (3)

Reactome (7)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence17

Enzyme-Mediated Modification (6)

6 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
DBN1	CDK5	Q00535	S	142	phosphorylation	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:30467237 ProtMapper:24637538 ProtMapper:25945928 ProtMapper:23979715
DBN1	CDK5	Q00535	S	342	phosphorylation	PhosphoSite
DBN1	CDK5	Q00535	S	144	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
DBN1	ATM	Q13315	S	647	phosphorylation	PhosphoSite
DBN1	CDK5R1	Q15078	S	142	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:25945928
DBN1	CDK1	P06493	S	141	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
gap_junction	gap_junction	GO_Intercell	Yes	Yes	No	No	No
gap_junction	gap_junction	OmniPath	Yes	Yes	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CDK5	Q00535	DREB	Q16643	Yes	Yes	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:24637538 PhosphoSite:28319065 ProtMapper:23979715 PhosphoSite:24637538 ProtMapper:30467237 PhosphoSite:23979715 ProtMapper:25945928 SIGNOR:23979715 PhosphoSite:30467237

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DBN1 DDX19A POU2F1 RABL2A SPTAN1 SPTBN1	P14859 Q01082 Q13813 Q16643 Q9NUU7 Q9UBK7	0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_509
	DBN1 ZMYND8	Q16643 Q9ULU4	2:2	PDB	PDB:5y1z

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryWestern blotting	7	38113368 33304478 40189497 35399949 41307968 38207106 38716512

Sequence, Structure & Domains11

Sequences

Length

649

Mass

71,429

Sequence

MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNASSVEDIDAGAIGQRLSNGLARLSSPVLHRLRLREDENAEPVGTTYQKTDAAVEMKRINREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQERVASASAGSCDVPSPFNHRPGSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPLPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQAQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVANNVPPAATSLIDLWPGNGEGASTLQGEPRAPTPPSGTEVTLAEVPLLDEVAPEPLLPAGEGCATLLNFDELPEPPATFCDPEEVEGESLAAPQTPTLPSALEELEQEQEPEPHLLTNGETTQKEGTQASEGYFSQSQEEEFAQSEELCAKAPPPVFYNKPPEIDITCWDADPVPEEEEGFEGGD

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Drebrin E, drebrin E2, Embryonic drebrin; IsoId=Q16643-1; Sequence=Displayed; Name=2; IsoId=Q16643-2; Sequence=VSP_028175; Name=3; Synonyms=Drebrin A; IsoId=Q16643-3; Sequence=VSP_053443

Alternative Sequence

4..29; VSFSGHRLELLAAYEEVIREESAADW -> HPWHGTAALASSQAWRDGRERQALVSCR (in isoform 2); 319; G -> GRPYCPFIKASDSGPSSSSSSSSSPPRTPFPYITCHRTPNLSSSLPC (in isoform 3)

3D Structural Models

Helix

10..21; 50..54; 55..57; 92..99; 102..108; 121..123; 126..132; 541..543

Beta Strand

23..26; 29..34; 40..49; 62..70; 72..74; 79..86; 114..120

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

208..236; Basic and acidic residues; 288..298; Basic and acidic residues; 334..348; Polar residues; 363..374; Pro residues; 582..594; Polar residues

Domain (FT)

3..134; ADF-H

Region

208..420; Disordered; 477..502; Disordered; 538..620; Disordered

Clinical Relevance6

Disease Involvement (3)

Alzheimer diseaseAmyloidosisNeurodegeneration

Drugs

GRASSYSTATIN A

Antibody (2)

HPA051452 HPA056940

Interaction Protein (3)

ENSG00000077549ENSG00000085733ENSG00000177885

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid

Supporting Publications4

PMID	Title	Abstract
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available