Protein detail

FSCN1

Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)

Protein symbol FSCN1	UniProt ID Q16658	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Cancer-related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55)

Protein Class

Cancer-related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Ensembl

ENSG00000075618

Entrez Gene Symbol

FSCN1

Gene Synonym

FLJ38511p55SNL

Gene Description

Fascin actin-bundling protein 1

Chromosome

Position

5592816-5606655

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificCardiomyocytesBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cellsSecretome LocationSecreted - unknown locationSecretome FunctionReceptor

Function & Pathway

Protein Function

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa05206 MicroRNAs in cancer

Reactome

Canonical Pathways

M16801 Sig regulation of the actin cytoskeleton by rho gtpases
M5193 Sig chemotaxis
M220 Pid caspase pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence

Enzyme-Mediated Modification

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
FSCN1	PRKCD	Q05655	S	39	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	HPRD:8999969 ProtMapper:8647875 KEA:8647875 KEA:8999969 HPRD:19651622 HPRD:20068231 HPRD:8647875 SIGNOR:8647875
FSCN1	PRKCA	P17252	S	39	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:24309511
FSCN1	PRKCA	P17252	S	38	phosphorylation	KEA	KEA:17570479
FSCN1	PRKCB	P05771	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
FSCN1	PRKCG	P05129	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
FSCN1	PRKCE	Q02156	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
FSCN1	FN1	P02751	S	39	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:22264292

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KPCD	Q05655	FSCN1	Q16658	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEAInnateDBSIGNOR_ProtMapperHPRD-phos	HPRD-phos:8647875 HPRD:8999969 ProtMapper:8647875 InnateDB:8999969 KEA:8647875 KEA:8999969 ProtMapper:19651622 ProtMapper:8999969 ProtMapper:20068231 HPRD:8647875 HPRD-phos:20068231 SIGNOR:8647875 InnateDB:8647875 HPRD-phos:19651622 HPRD-phos:8999969
KPCA	P17252	FSCN1	Q16658	Yes	No	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetPhosphoPointProtMapperHPRDKEAREACH_ProtMapperPhosphoSiteNetworKIN_KEA	PhosphoSite:30664308 ProtMapper:24309511 PhosphoSite:20713986 HPRD:14532112 PhosphoSite:28251354 ProtMapper:30683702 PhosphoSite:32294157 PhosphoSite:8999969 KEA:17570479 PhosphoSite:27554857 PhosphoSite:20137952

Protein Complex Composition

13 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
FSCN1	Q16658	2	PDB	PDB:4goyPDB:6i0zPDB:9fn6PDB:3p53PDB:7zauPDB:1dfcPDB:6b0tPDB:4gp3PDB:4govPDB:3llpPDB:4gp0
FSCN1 WDR82	Q16658 Q6UXN9	0:0	hu.MAP
CARHSP1 FSCN1	Q16658 Q9Y2V2	0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	0

Sequence, Structure & Domains

Sequences

Length

493

Mass

54,530

Sequence

MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY

3D Structural Models

Turn

106..108; 147..150; 235..238; 268..270; 300..302; 310..312; 399..401

Helix

42..44; 53..55; 87..89; 116..118; 128..130; 173..175; 208..210; 250..252; 290..292; 332..334; 372..374; 487..489

Beta Strand

14..17; 23..26; 28..31; 33..39; 46..49; 60..64; 65..67; 69..72; 78..84; 91..95; 97..99; 101..105; 111..113; 120..125; 132..138; 140..146; 151..155; 158..160; 162..169; 177..181; 183..189; 198..200; 202..205; 212..217; 220..224; 226..228; 230..234; 239..242; 254..258; 261..266; 272..275; 278..280; 282..286; 294..298; 305..308; 314..317; 321..329; 336..341; 344..348; 354..357; 361..369; 376..380; 384..386; 393..397; 403..410; 414..419; 422..426; 432..435; 439..447; 451..457; 460..465; 468..472; 476..484; 490..492

3D Structure

Electron microscopy (7); X-ray crystallography (20)

Domain & Motif Annotations

Domain (CC)

Composed of four fascin beta-trefoil domains.

Protein Families

Fascin family

Sequence Similarities

Belongs to the fascin family.

Clinical Relevance

Disease Involvement

Cancer-related genes

Related Diseases

Solid tumour/cancer

Biomarker

Phase 1

Drug Targets

Clinical trial target

Drugs

NP-G2-044

Antibody

CAB000121 HPA005723 CAB035991 HPA050654 CAB080327