Protein detail

CAH9

Carbonic anhydrase 9 (EC 4.2.1.1) (Carbonate dehydratase IX) (Carbonic anhydrase IX) (CA-IX) (CAIX) (Membrane antigen MN) (P54/58N) (Renal cell carcinoma-associated antigen G250) (RCC-associated antigen G250) (pMW1)

Entry name CAH9	UniProt ID Q16790	EVMP score 0.38
Frequency 1	Transmembrane count 1	Protein classification EnzymesFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Protein Class

EnzymesFDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters

Protein Function

Enzymes
FDA approved drug targets:Small molecule drugs
ENZYME proteins:Lyases
Transporters:Accessory Factors Involved in Transport

Transmembrane

415..435; Helical

Transmembrane Count

Ensembl

ENSG00000107159

Entrez Gene Symbol

CA9

Gene Synonym

CAIXMN

Gene Description

Carbonic anhydrase 9

Chromosome

Position

35673928-35681159

Frequency

EVMP Score

0.38

Fluorescence & Localization

Cell SpecificAdipocytesSingle-Nuclei Brain Specifichippocampal CA4Blood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cellsSecretome LocationSecreted in other tissuesSecretome FunctionReceptor

Function & Pathway

Protein Function

Enzymes
FDA approved drug targets:Small molecule drugs
ENZYME proteins:Lyases
Transporters:Accessory Factors Involved in Transport

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CA9	PRKACA	P17612	T	443	phosphorylation	PhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:22037869 SIGNOR:22037869
CA9	EGFR	P00533	Y	449	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:29439394
CA9	EGF	P01133	Y	449	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:20920536

Ligand-Receptor Signaling

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KAPCA	P17612	CAH9	Q16790	Yes	Yes	No	PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:28692057 SIGNOR:22037869 ProtMapper:22037869 PhosphoSite:22037869

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ABCA9 AHSA1 ARF1 ARF4 ARL8B ETFA HSD17B12 KDELR2 LDHA RAB1A RAB2A RPN1 SLC27A4 SSR2 VPS4B	O75351 O95433 P00338 P04843 P13804 P18085 P33947 P43308 P61019 P62820 P84077 Q53GQ0 Q6P1M0 Q8IUA7 Q9NVJ2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8839
	CA9	Q16790	4	PDB	PDB:6tl5PDB:6qn5PDB:6qn2PDB:5fl6PDB:6g9uPDB:9flfPDB:6fe0PDB:6fe2PDB:8q1aPDB:6g98PDB:6qn6PDB:8co0PDB:6y74PDB:6fe1PDB:5fl5PDB:6qutPDB:3iaiPDB:5dvxPDB:6rqqPDB:6tl6PDB:8q18PDB:5fl4PDB:8q19PDB:7pom

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometryMass spectrometry [LTQ-FT Ultra]	28	26826536 36064647 38113368 40465195 37322475 36497184 34064677 33936570 40189497 41068253 33592500 30915084 32560723 32916986 41307968 36146834 40840701 32230970 38207106 34576246 37204515 39001700 36982312 37438638 39207047 32854315 27792649 37926756

Sequence, Structure & Domains

Sequences

Length

459

Mass

49,698

Sequence

MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA

3D Structural Models

Turn

137..139; 150..152; 294..296

Helix

154..157; 168..170; 262..265; 287..293; 297..299; 313..316; 353..361; 366..368

Beta Strand

143..147; 164..166; 171..173; 181..184; 193..197; 202..205; 211..215; 218..229; 238..241; 247..256; 271..281; 305..308; 324..330; 338..347; 349..351; 387..390

3D Structure

X-ray crystallography (28)

Domain & Motif Annotations

Compositional Bias

55..95; Acidic residues; 96..112; Basic and acidic residues; 129..140; Basic and acidic residues

Domain (FT)

139..390; Alpha-carbonic anhydrase

Region

38..112; Proteoglycan-like (PG); 42..154; Disordered; 138..391; Catalytic

Protein Families

Alpha-carbonic anhydrase family

Sequence Similarities

Belongs to the alpha-carbonic anhydrase family.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

CELECOXIB SUNITINIB VALSPODAR ETHOXZOLAMIDE IODINE I 124 GIRENTUXIMAB ZOSUQUIDAR CG250 111IN BIRICODAR ENCEQUIDAR CG250 177LU WS-898 SULTHIAME GIRENTUXIMAB COMPOUND 14 [PMID: 30925062]

Antibody

CAB005100 CAB017107 HPA055207

Interaction Protein

ENSG00000108010

Interaction Count

Interaction Dataset

intact_biogrid