Protein detail
DDR2
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Protein symbol DDR2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- CD markers
- Enzymes
- Cancer-related genes
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
400..421; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificColonocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- CD markers
- Enzymes
- Cancer-related genes
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DDR2 | SRC | P12931 | Y | 736 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:18083107KEA:16186108SIGNOR:16186108ProtMapper:16186108 |
| DDR2 | SRC | P12931 | Y | 740 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:16186108ProtMapper:16186108dbPTM:18083107ProtMapper:28270508KEA:16186108 |
| DDR2 | SRC | P12931 | Y | 741 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | dbPTM:-KEA:16186108SIGNOR:16186108ProtMapper:16186108 |
| DDR2 | SRC | P12931 | Y | 471 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper | KEA:11884411 |
Ligand-Receptor Signaling
56 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor_tyrosine_kinases_rtk | receptor | HPMR | No | Yes | No | Yes | No |
| discoidin_domain_receptor | receptor | HPMR | No | Yes | No | Yes | No |
| kinase | receptor | Surfaceome | No | Yes | No | Yes | No |
| ecm_interaction | receptor | ICELLNET | No | Yes | No | Yes | No |
| ecm_interaction_col | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| DDR2 | Q16832 | SHC1 | P29353 | Yes | Yes | No | PhosphoPointSIGNORHPRDSignaLink3IntActSPIKE_LCLit-BM-17 | SIGNOR:16186108IntAct:11884411SignaLink3:11884411SPIKE_LC:11884411Lit-BM-17:11884411HPRD:11884411SignaLink3:23331499 |
| SRC | P12931 | DDR2 | Q16832 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAHPRDKinexus_KEAPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LC | SIGNOR:16186108ProtMapper:16186108SPIKE_LC:11884411PhosphoSite:11884411KEA:11884411dbPTM:18083107PhosphoSite:16186108HPRD:11884411ProtMapper:29701112ProtMapper:28270508KEA:16186108HPRD:16186108 |
| DDR2 | Q16832 | SRC | P12931 | Yes | Yes | No | ProtMapperHPRDSignaLink3SPIKE_LCREACH_ProtMapper | SignaLink3:16186108SignaLink3:11884411SPIKE_LC:11884411ProtMapper:21288331HPRD:11884411SignaLink3:23331499HPRD:16186108 |
| CO1A1 | P02452 | DDR2 | Q16832 | Yes | Yes | No | iTALKICELLNETSIGNORHINTHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerEMBRACEFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb | HINT:16884738connectomeDB2020:12611880HPRD:9659899Baccin2019:9659899Cellinker:12611880LRdb:97SIGNOR:17318226HINT:9659899CellTalkDB:12611880LRdb:12611880ICELLNET:9659900Baccin2019:12611880ICELLNET:16626936HPMR:12611880connectomeDB2020:9659899Cellinker:9659899 |
| COLA1 | Q96P44 | DDR2 | Q16832 | Yes | Yes | No | SIGNOR | SIGNOR:17318226 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 32795414 |
Sequence, Structure & Domains
Sequences
Length
855
Mass
96,736
Sequence
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
3D Structural Models
Turn
27..29; 36..38; 751..753; 788..791
Helix
43..45; 54..56; 58..60; 107..109; 560..562; 616..630; 662..667; 684..703; 713..715; 720..722; 734..739; 756..759; 766..782; 794..806; 822..831; 836..838; 842..849
Beta Strand
33..35; 39..41; 46..49; 70..72; 87..103; 116..128; 135..137; 140..142; 145..149; 151..169; 171..174; 178..186; 565..571; 576..581; 604..609; 642..644; 646..649; 651..655; 716..718; 724..726; 744..746; 818..820
3D Structure
NMR spectroscopy (1); X-ray crystallography (4)
Domain & Motif Annotations
Domain (FT)
30..185; F5/8 type C; 563..849; Protein kinase
Region
452..471; Disordered
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- Insulin receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Clinical Relevance
Interaction Protein
ENSG00000096384ENSG00000105401ENSG00000140538ENSG00000160691ENSG00000204580
Interaction Count
5
Interaction Dataset
intact_biogrid