Protein detail

DDR2

Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)

Entry name DDR2	UniProt ID Q16832	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Protein Function (9)

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
CD markers
Enzymes
Cancer-related genes
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

400..421; Helical

Transmembrane Count

Ensembl

ENSG00000162733

Entrez Gene Symbol

DDR2

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificColonocytes

Function & Pathway5

Protein Function (9)

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
CD markers
Enzymes
Cancer-related genes
Kinases:Tyr protein kinases
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (5)

Molecular Function (5)

Reactome (2)

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence68

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
DDR2	SRC	P12931	Y	736	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	dbPTM:18083107 KEA:16186108 SIGNOR:16186108 ProtMapper:16186108
DDR2	SRC	P12931	Y	740	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:16186108 ProtMapper:16186108 dbPTM:18083107 ProtMapper:28270508 KEA:16186108
DDR2	SRC	P12931	Y	741	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	dbPTM:-KEA:16186108 SIGNOR:16186108 ProtMapper:16186108
DDR2	SRC	P12931	Y	471	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:11884411

Ligand-Receptor Signaling (56)

56 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	talklr	No	Yes	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	connectomeDB2020	No	Yes	No	Yes	No
receptor	receptor	iTALK	No	Yes	No	Yes	No
receptor	receptor	Almen2009	No	Yes	No	Yes	No
receptor	receptor	CellCellInteractions	No	Yes	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
DDR2	Q16832	SHC1	P29353	Yes	Yes	No	PhosphoPointSIGNORHPRDSignaLink3IntActSPIKE_LCLit-BM-17	SIGNOR:16186108 IntAct:11884411 SignaLink3:11884411 SPIKE_LC:11884411 Lit-BM-17:11884411 HPRD:11884411 SignaLink3:23331499
SRC	P12931	DDR2	Q16832	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAHPRDKinexus_KEAPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperSPIKE_LC	SIGNOR:16186108 ProtMapper:16186108 SPIKE_LC:11884411 PhosphoSite:11884411 KEA:11884411 dbPTM:18083107 PhosphoSite:16186108 HPRD:11884411 ProtMapper:29701112 ProtMapper:28270508 KEA:16186108 HPRD:16186108
DDR2	Q16832	SRC	P12931	Yes	Yes	No	ProtMapperHPRDSignaLink3SPIKE_LCREACH_ProtMapper	SignaLink3:16186108 SignaLink3:11884411 SPIKE_LC:11884411 ProtMapper:21288331 HPRD:11884411 SignaLink3:23331499 HPRD:16186108
CO1A1	P02452	DDR2	Q16832	Yes	Yes	No	iTALKICELLNETSIGNORHINTHPMR_talklrHPMRHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerEMBRACEFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020LRdb	HINT:16884738 connectomeDB2020:12611880 HPRD:9659899 Baccin2019:9659899 Cellinker:12611880LRdb:97SIGNOR:17318226 HINT:9659899 CellTalkDB:12611880 LRdb:12611880 ICELLNET:9659900 Baccin2019:12611880 ICELLNET:16626936 HPMR:12611880 connectomeDB2020:9659899 Cellinker:9659899
COLA1	Q96P44	DDR2	Q16832	Yes	Yes	No	SIGNOR	SIGNOR:17318226

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	DDR2	Q16832	12	PDB	PDB:6fer
	CHORDC1 DDR2	Q16832 Q9UHD1	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	1	32795414

Sequence, Structure & Domains11

Sequences

Length

855

Mass

96,736

Sequence

MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE

3D Structural Models

Turn

27..29; 36..38; 751..753; 788..791

Helix

43..45; 54..56; 58..60; 107..109; 560..562; 616..630; 662..667; 684..703; 713..715; 720..722; 734..739; 756..759; 766..782; 794..806; 822..831; 836..838; 842..849

Beta Strand

33..35; 39..41; 46..49; 70..72; 87..103; 116..128; 135..137; 140..142; 145..149; 151..169; 171..174; 178..186; 565..571; 576..581; 604..609; 642..644; 646..649; 651..655; 716..718; 724..726; 744..746; 818..820

3D Structure

NMR spectroscopy (1); X-ray crystallography (4)

Domain & Motif Annotations

Domain (FT)

30..185; F5/8 type C; 563..849; Protein kinase

Region

452..471; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
Insulin receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Clinical Relevance4

Drugs (6)

DASATINIB ANHYDROUS NILOTINIB REGORAFENIB SARACATINIB ERLOTINIB NULL

Interaction Protein (5)

ENSG00000096384ENSG00000105401ENSG00000140538ENSG00000160691ENSG00000204580

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
33553692	Ligand-competent fractalkine receptor is expressed on exosomes.	Although we found that all the exosomes tested in our study highly expressed CX3CR1, this chemokine receptor was expressed only inside, but barely on, their source cells. Here, we investigated CX3CR1 expression on exosomes isolated from various cell types. Therefore, our study suggests that CX3CR1 is a novel and ligand-competent exosome receptor.