Protein detail
TPD53
Tumor protein D53 (hD53) (Tumor protein D52-like 1)
Entry name TPD53 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tumor protein D53 (hD53) (Tumor protein D52-like 1)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
D53hD53TPD53
Gene Description
TPD52 like 1
Chromosome
6
Position
125119049-125264407
Supporting publications (n)
1
EVMP confidence score
0.28
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (3)
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence8
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TPD52L1TPD52L2 | O43399Q16890 | 0:0 | hu.MAP2 | |||
| FAM117BMPRIPPSMC3STKLD1TPD52L1TRAF4 | P17980Q16890Q6P1L5Q6WCQ1Q8NE28Q9BUZ4 | 0:0:0:0:0:0 | hu.MAP | |||
| RPS5TPD52L1 | P46782Q16890 | 0:0 | hu.MAP2 | |||
| DHX57RPS5TPD52L1 | P46782Q16890Q6P158 | 0:0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [MALDI TOF] | 1 | 40326690 |
Sequence, Structure & Domains
Sequences
Length
204
Mass
22,449
Sequence
MEAQAQGLLETEPLQGTDEDAVASADFSSMLSEEEKEELKAELVQLEDEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSKSWHDMQTTTAYKKTHETLSHAGQKATAAFSNVGTAISKKFGDMSYSIRHSISMPAMRNSPTFKSFEERVETTVTSLKTKVGGTNPNGGSFEEVLSSTAHASAQSLAGGSRRTKEEELQC
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q16890-1; Sequence=Displayed; Name=2; IsoId=Q16890-2; Sequence=VSP_036754, VSP_036755; Name=3; IsoId=Q16890-3; Sequence=VSP_036752, VSP_036753; Name=4; Synonyms=+5hD53; IsoId=Q16890-4; Sequence=VSP_036751, VSP_036752, VSP_036753; Name=5; IsoId=Q16890-5; Sequence=VSP_036751
Alternative Sequence
1..29; Missing (in isoform 4 and isoform 5); 129..131; SYS -> RRK (in isoform 3 and isoform 4); 132..204; Missing (in isoform 3 and isoform 4); 143..144; NS -> RK (in isoform 2); 145..204; Missing (in isoform 2)
Domain & Motif Annotations
Coiled Coil
22..73
Region
1..20; Disordered
Protein Families
TPD52 family
Sequence Similarities
Belongs to the TPD52 family.
Clinical Relevance
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |