Protein detail

TPD53

Tumor protein D53 (hD53) (Tumor protein D52-like 1)

Entry name TPD53	UniProt ID Q16890	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Tumor protein D53 (hD53) (Tumor protein D52-like 1)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000111907

Entrez Gene Symbol

TPD52L1

Gene Synonym (3)

D53hD53TPD53

Gene Description

TPD52 like 1

Chromosome

Position

125119049-125264407

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

Reactome (4)

Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence8

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
TPD52L1 TPD52L2	O43399 Q16890	0:0	hu.MAP2
FAM117B MPRIP PSMC3 STKLD1 TPD52L1 TRAF4	P17980 Q16890 Q6P1L5 Q6WCQ1 Q8NE28 Q9BUZ4	0:0:0:0:0:0	hu.MAP
RPS5 TPD52L1	P46782 Q16890	0:0	hu.MAP2
DHX57 RPS5 TPD52L1	P46782 Q16890 Q6P158	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [MALDI TOF]	1	40326690

Sequence, Structure & Domains9

Sequences

Length

204

Mass

22,449

Sequence

MEAQAQGLLETEPLQGTDEDAVASADFSSMLSEEEKEELKAELVQLEDEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSKSWHDMQTTTAYKKTHETLSHAGQKATAAFSNVGTAISKKFGDMSYSIRHSISMPAMRNSPTFKSFEERVETTVTSLKTKVGGTNPNGGSFEEVLSSTAHASAQSLAGGSRRTKEEELQC

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q16890-1; Sequence=Displayed; Name=2; IsoId=Q16890-2; Sequence=VSP_036754, VSP_036755; Name=3; IsoId=Q16890-3; Sequence=VSP_036752, VSP_036753; Name=4; Synonyms=+5hD53; IsoId=Q16890-4; Sequence=VSP_036751, VSP_036752, VSP_036753; Name=5; IsoId=Q16890-5; Sequence=VSP_036751

Alternative Sequence

1..29; Missing (in isoform 4 and isoform 5); 129..131; SYS -> RRK (in isoform 3 and isoform 4); 132..204; Missing (in isoform 3 and isoform 4); 143..144; NS -> RK (in isoform 2); 145..204; Missing (in isoform 2)

Domain & Motif Annotations

Coiled Coil

22..73

Region

1..20; Disordered

Protein Families

TPD52 family

Sequence Similarities

Belongs to the TPD52 family.

Clinical Relevance4

Antibody (2)

HPA027915 HPA027916

Interaction Protein

ENSG00000076554

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
27894104	Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.	No abstract available