Protein detail
LONF1
LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191)
Entry name LONF1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ23749RNF191
Gene Description
LON peptidase N-terminal domain and ring finger 1
Chromosome
8
Position
12721906-12756073
Supporting publications (n)
3
EVMP confidence score
0.38
Fluorescence & Localization1
Cell SpecificEarly primary spermatocytes
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories
Immune mediation
Relations & Evidence147
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (136)
136 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P0CG48_Q96LR5 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62987_Q96B02 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P68036 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_P62837 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_P61081 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q15819 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P62979_Q5JXB2 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_Q9NR09 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:O14933_P0CG48 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P60604_P62979 | LONF1 | Q17RB8 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 |
Protein Complex Composition (7)
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Ub:RING_E3 | LONRF1UBB | P0CG47Q17RB8 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | LONRF1UBC | P0CG48Q17RB8 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | LONRF1RPS27A | P62979Q17RB8 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| Ub:RING_E3 | LONRF1UBA52 | P62987Q17RB8 | 0:0 | SIGNOR | SIGNOR:SIGNOR-C519 | |
| ECI1GSRISCULONRF1PSAP | P00390P07602P42126Q17RB8Q9H1K1 | 0:0:0:0:0 | hu.MAP2 | |||
| ALDH4A1GPTIBA57ISCULONRF1TMEM184A | P24298P30038Q17RB8Q5T440Q6ZMB5Q9H1K1 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ISCULONRF1 | Q17RB8Q9H1K1 | 0:0 | hu.MAP2 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains10
Sequences
Length
773
Mass
86,725
Sequence
MSSPAVARTSPGGSREMAPAPQGRGRFWEVGGGSGHRLERAAAESERWELLLRRGELLALGGHLKGALEAFAAALRRGAPARPECLGALVDCLVFNYRLRHGLGWSAAPVAGADGGAGGLLRCLGCRGFLSEPVTVPCGHSYCRRCLRRELRARCRLCRDRLPPATASATDAEGTAPRPPPLAAAIAASDFRTSVVLNHLAEKWFPGQRERARAAGRLGELLHQGRYREALAAACEALRAEPSDLIVKIYRAESYAGLQEFKAAIEDLNAVLFQLPDWPEVYFRKGKVLCDAGFLGDALQLFLQCLALDEDFAPAKLQVQKILCDLLLPENLKEGLKESSWSSLPCTKNRPFDFHSVMEESQSLNEPSPKQSEEIPEVTSEPVKGSLNRAQSAQSINSTEMPAREDCLKRVSSEPVLSVQEKGVLLKRKLSLLEQDVIVNEDGRNKLKKQGETPNEVCMFSLAYGDIPEELIDVSDFECSLCMRLFFEPVTTPCGHSFCKNCLERCLDHAPYCPLCKESLKEYLADRRYCVTQLLEELIVKYLPDELSERKKIYDEETAELSHLTKNVPIFVCTMAYPTVPCPLHVFEPRYRLMIRRSIQTGTKQFGMCVSDTQNSFADYGCMLQIRNVHFLPDGRSVVDTVGGKRFRVLKRGMKDGYCTADIEYLEDVKVENEDEIKNLRELHDLVYSQACSWFQNLRDRFRSQILQHFGSMPEREENLQAAPNGPAWCWWLLAVLPVDPRYQLSVLSMKSLKERLTKIQHILTYFSRDQSK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q17RB8-1; Sequence=Displayed; Name=2; IsoId=Q17RB8-2; Sequence=VSP_037971
Alternative Sequence
452..462; Missing (in isoform 2)
Domain & Motif Annotations
Compositional Bias
359..370; Polar residues
Repeat
48..81; TPR 1; 212..244; TPR 2; 246..278; TPR 3; 279..312; TPR 4
Zinc Finger
123..159; RING-type 1; 479..517; RING-type 2
Domain (FT)
558..768; Lon N-terminal
Region
1..29; Disordered; 359..388; Disordered
Clinical Relevance4
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No abstract available |
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No abstract available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |