Protein detail

LY6K

Lymphocyte antigen 6K (Ly-6K)

Entry name LY6K	UniProt ID Q17RY6	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted membrane proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Lymphocyte antigen 6K (Ly-6K)

Protein Class (2)

Predicted membrane proteinsPredicted secreted proteins

Protein Function

Predicted secreted proteins

Ensembl

ENSG00000160886

Entrez Gene Symbol

LY6K

Gene Synonym (3)

CT97FLJ35226HSJ001348

Gene Description

Lymphocyte antigen 6 family member K

Chromosome

Position

142700111-142705127

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificSertoli cells

Function & Pathway5

Protein Function

Predicted secreted proteins

Cellular Component (5)

Biological Process (3)

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence23

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface	cell_surface	OmniPath	No	No	Yes	Yes	Yes
transmembrane	transmembrane_predicted	Phobius	No	No	Yes	Yes	Yes

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	3	40784529 37686366 41201090

Sequence, Structure & Domains6

Sequences

Length

165

Mass

18,673

Sequence

MALLALLLVVALPRVWTDANLTARQRDPEDSQRTDEGDNRVWCHVCERENTFECQNPRRCKWTEPYCVIAAVKIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLEEPMPFFYLKCCKIRYCNLEGPPINSSVFKEYAGSMGESCGGLWLAILLLLASIAAGLSLS

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q17RY6-1; Sequence=Displayed; Name=2; IsoId=Q17RY6-2; Sequence=VSP_045602, VSP_045603

Alternative Sequence

73..105; KIFPRFFMVAKQCSAGCAAMERPKPEEKRFLLE -> TVLRWLCSDGETQARGEAVSPGRAHALLLPQVL (in isoform 2); 106..165; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

47..141; UPAR/Ly6

Clinical Relevance1

Antibody (5)

HPA017770 CAB075742 CAB075743 CAB079929 CAB080500

Supporting Publications1

PMID	Title	Abstract
26775013	Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.	No abstract available