Protein detail
SC5AC
Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)
Entry name SC5AC | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 13 | Protein classification Metabolic proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Sodium-coupled monocarboxylate transporter 2 (Electroneutral sodium monocarboxylate cotransporter) (Low-affinity sodium-lactate cotransporter) (Solute carrier family 5 member 12)
Protein Class
Metabolic proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Electrochemical Potential-driven transporters
Transmembrane
10..30; Helical; 48..68; Helical; 83..103; Helical; 129..149; Helical; 158..178; Helical; 181..201; Helical; 236..256; Helical; 276..296; Helical; 322..342; Helical; 386..406; Helical; 412..432; Helical; 438..458; Helical; 505..525; Helical
Transmembrane Count
13
Ensembl
Entrez Gene Symbol
Gene Synonym
MGC52019SMCT2
Gene Description
Solute carrier family 5 member 12
Chromosome
11
Position
26667020-26723427
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcerebellar inhibitoryBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
Transporters:Electrochemical Potential-driven transporters
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
23 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 32795414 |
Sequence, Structure & Domains
Sequences
Length
618
Mass
67,647
Sequence
MEVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTASFMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFNKPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKAVVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWTITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSHFKDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVTFEDFVKSCFPHLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPMLGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPLPLSTDQCIKSNVTATGPPVLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIRPVCNLFCFWSKKYKTLCWCGVQHDSGTEQENLENGSARKQGAESVLQNGLRRESLVHVPGYDPKDKSYNNMAFETTHF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q1EHB4-1; Sequence=Displayed; Name=2; IsoId=Q1EHB4-2; Sequence=VSP_033994, VSP_033995
Alternative Sequence
386..396; LLFGVMCTSMA -> RYSWWTFYSIS (in isoform 2); 397..618; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Clinical Relevance
Antibody