Protein detail

ISK13

Serine protease inhibitor Kazal-type 13 (Hepatitis B virus DNA polymerase transactivated serine protease inhibitor) (Hespintor) (Serine protease inhibitor Kazal-type 5-like 3)

Entry name ISK13	UniProt ID Q1W4C9	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Serine protease inhibitor Kazal-type 13 (Hepatitis B virus DNA polymerase transactivated serine protease inhibitor) (Hespintor) (Serine protease inhibitor Kazal-type 5-like 3)

Protein Class (2)

Predicted intracellular proteinsPredicted secreted proteins

Protein Function (2)

Predicted secreted proteins
Predicted intracellular proteins

Ensembl

ENSG00000214510

Entrez Gene Symbol

SPINK13

Gene Synonym (4)

HESPINTORLiESP6MGC149260SPINK5L3

Gene Description

Serine peptidase inhibitor Kazal type 13

Chromosome

Position

148268180-148286255

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificGoblet cellsBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes

Function & Pathway4

Protein Function (2)

Predicted secreted proteins
Predicted intracellular proteins

Cellular Component

GO:0005576 extracellular region

Molecular Function (2)

Mediation Categories

Other mediation

Relations & Evidence9

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	Yes	No	No
ecm	ecm	OmniPath	Yes	No	Yes	No	No
serine_peptidase_inhibitor	secreted_peptidase_inhibitor	HGNC	No	No	Yes	No	No
secreted_peptidase_inhibitor	secreted_peptidase_inhibitor	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	HPA_secretome	No	No	Yes	No	No
secreted	secreted	OmniPath	No	No	Yes	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingELISA	2	40784529 37922300

Sequence, Structure & Domains6

Sequences

Length

Mass

11,051

Sequence

MAAFPHKIIFFLVCSTLTHVAFSGIFNKRDFTRWPKPRCKMYIPLDPDYNADCPNVTAPVCASNGHTFQNECFFCVEQREFHYRIKFEKYGKCD

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q1W4C9-1; Sequence=Displayed; Name=2; IsoId=Q1W4C9-2; Sequence=VSP_034842

Alternative Sequence

1..40; Missing (in isoform 2)

Domain & Motif Annotations

Domain (FT)

33..94; Kazal-like

Clinical Relevance1

Antibody

HPA036456

Supporting Publications1

PMID	Title	Abstract
40784529	Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine.	No abstract available