Protein detail
MICA
MHC class I polypeptide-related sequence A (MIC-A)
Protein symbol MICA | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
MHC class I polypeptide-related sequence A (MIC-A)
Protein Function
Predicted intracellular proteins
Transmembrane
308..328; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M82 Pid ret pathway
- M142 Pid ajdiss 2pathway
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
42 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | No |
| extracellular | extracellular | LOCATE | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | ComPPI | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | Yes | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | Yes | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
383
Mass
42,915
Sequence
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=MICA1; IsoId=Q29983-1; Sequence=Displayed; Name=2; Synonyms=MICA2; IsoId=Q29983-2; Sequence=VSP_055366
Alternative Sequence
109..204; Missing (in isoform 2)
3D Structural Models
Turn
87..90; 145..148; 198..200
Helix
79..81; 83..86; 91..101; 156..171; 177..197; 217..219; 248..250; 277..279
Beta Strand
26..37; 46..51; 54..60; 63..65; 71..75; 109..121; 127..135; 138..144; 149..151; 208..214; 220..233; 236..241; 251..253; 260..262; 264..273; 280..286; 289..294
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Domain (FT)
207..296; Ig-like C1-type
Protein Families
- MHC class I family
- MIC subfamily
Sequence Similarities
Belongs to the MHC class I family. MIC subfamily.