Protein detail
LRC26
Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) (Cytokeratin-associated protein in cancer)
Entry name LRC26 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Predicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Leucine-rich repeat-containing protein 26 (BK channel auxiliary gamma subunit LRRC26) (Cytokeratin-associated protein in cancer)
Protein Class (2)
Predicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Transmembrane
262..282; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
bA350O14.10
Gene Description
Leucine rich repeat containing 26
Chromosome
9
Position
137168758-137170051
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway5
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence19
Ligand-Receptor Signaling (18)
18 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometry | 1 | 32795414 |
Sequence, Structure & Domains14
Sequences
Length
334
Mass
34,857
Sequence
MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTAALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=L-CAPC; IsoId=Q2I0M4-1; Sequence=Displayed; Name=2; Synonyms=S-CAPC; IsoId=Q2I0M4-2; Sequence=VSP_040058, VSP_040205
Alternative Sequence
1..289; Missing (in isoform 2); 290; C -> M (in isoform 2)
3D Structural Models
Turn
51..53; 88..93; 112..117; 136..141
Helix
160..163; 187..189; 207..209; 210..218; 223..226; 242..244; 248..250; 260..292
Beta Strand
45..50; 54..56; 75..77; 99..101; 123..125; 147..149; 171..173; 195..197; 233..236; 251..253; 297..299
3D Structure
Electron microscopy (7)
Domain & Motif Annotations
Compositional Bias
304..313; Pro residues; 320..334; Low complexity
Repeat
72..93; LRR 1; 96..117; LRR 2; 120..141; LRR 3; 144..167; LRR 4; 168..190; LRR 5
Domain (CC)
The transmembrane domain is necessary for interaction with KCNMA1.
Domain (FT)
34..71; LRRNT; 201..255; LRRCT
Region
298..334; Disordered
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 34771645 | GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer. | No abstract available |