Protein detail

CQ058

UPF0450 protein C17orf58

Protein symbol
CQ058
UniProt ID
EVMP score
0.38
Frequency
1
Transmembrane count
Protein classification
Essential proteinsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
UPF0450 protein C17orf58
Protein Class
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Entrez Gene Symbol
Gene Description
Chromosome 17 open reading frame 58
Chromosome
17
Position
67991099-67996469
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
Predicted intracellular proteins
Canonical Pathways
  • M5887 Naba basement membranes
  • M3008 Naba ecm glycoproteins
  • M5884 Naba core matrisome
Mediation Categories
Other mediation
Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

2 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecm_regulatorecm_regulatorMatrisomeYesNoNoNoNo
ecm_regulatorecm_regulatorOmniPathYesNoNoNoNo

Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blotting439290459315085003372925530760538
Sequence, Structure & Domains

Sequences

Length
339
Mass
36,985
Sequence
MTARAFWLLCLIVGSSPEAPVAERKTSPPHSRKPDSRGCPSAEETPGPRAQPLLEAPQRPRAAEVAPAARAWPDPRRRKPPPPADNQASFREAARAPAGPPGPRLAQAENRASPRREPASEDAPRRARSRALRFPAARPPALATEGSAGHAHPNRPRAAALAPGPAPAPPPRFSLSFGLSPPQRDAEPGAEPCARACRSDLDEREAFCESEFAVNGIVHDVDVLGAGIRLVTLLVDRDGLYKMNRLYLTPDGFFFRVHMLALDSSSCNKPCPEFKPGSRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2M2W7-1; Sequence=Displayed; Name=2; IsoId=Q2M2W7-2; Sequence=VSP_036597
Alternative Sequence
278..339; SRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI -> IETDLNDAAYVLYTTVCNVGATARAVGRPAFFWERWGTMT (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias
21..36; Basic and acidic residues; 56..72; Low complexity; 112..125; Basic and acidic residues; 132..163; Low complexity
Domain (FT)
193..338; NTR
Region
17..191; Disordered
Protein Families
UPF0450 family
Sequence Similarities
Belongs to the UPF0450 family.
Clinical Relevance
Antibody