Protein detail

CQ058

UPF0450 protein C17orf58

Entry name CQ058	UniProt ID Q2M2W7	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

UPF0450 protein C17orf58

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000186665

Entrez Gene Symbol

C17orf58

Gene Description

Chromosome 17 open reading frame 58

Chromosome

Position

67991099-67996469

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue Specificskin 1Cell SpecificBrain excitatory neurons

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0062023 collagen-containing extracellular matrix

Biological Process (3)

Canonical Pathways (3)

M5887 Naba basement membranes
M3008 Naba ecm glycoproteins
M5884 Naba core matrisome

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm_regulator	ecm_regulator	Matrisome	Yes	No	No	No	No
ecm_regulator	ecm_regulator	OmniPath	Yes	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blotting	4	39290459 31508500 33729255 30760538

Sequence, Structure & Domains10

Sequences

Length

339

Mass

36,985

Sequence

MTARAFWLLCLIVGSSPEAPVAERKTSPPHSRKPDSRGCPSAEETPGPRAQPLLEAPQRPRAAEVAPAARAWPDPRRRKPPPPADNQASFREAARAPAGPPGPRLAQAENRASPRREPASEDAPRRARSRALRFPAARPPALATEGSAGHAHPNRPRAAALAPGPAPAPPPRFSLSFGLSPPQRDAEPGAEPCARACRSDLDEREAFCESEFAVNGIVHDVDVLGAGIRLVTLLVDRDGLYKMNRLYLTPDGFFFRVHMLALDSSSCNKPCPEFKPGSRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2M2W7-1; Sequence=Displayed; Name=2; IsoId=Q2M2W7-2; Sequence=VSP_036597

Alternative Sequence

278..339; SRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI -> IETDLNDAAYVLYTTVCNVGATARAVGRPAFFWERWGTMT (in isoform 2)

Domain & Motif Annotations

Compositional Bias

21..36; Basic and acidic residues; 56..72; Low complexity; 112..125; Basic and acidic residues; 132..163; Low complexity

Domain (FT)

193..338; NTR

Region

17..191; Disordered

Protein Families

UPF0450 family

Sequence Similarities

Belongs to the UPF0450 family.

Clinical Relevance1

Antibody

HPA023036

Supporting Publications1

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available