Protein detail

CQ058

UPF0450 protein C17orf58

Entry name
CQ058
UniProt ID
Q2M2W7
EVMP confidence score
0.40
Supporting publications (n)
1
Transmembrane count
Protein classification
Essential proteinsPredicted intracellular proteins
Basic Information
Protein Names
UPF0450 protein C17orf58
Protein Class (2)
Essential proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000186665
Entrez Gene Symbol
C17orf58
Gene Description
Chromosome 17 open reading frame 58
Chromosome
17
Position
67991099-67996469
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
GO:0062023 collagen-containing extracellular matrix
Biological Process (3)
Canonical Pathways (3)
  • M5887 Naba basement membranes
  • M3008 Naba ecm glycoproteins
  • M5884 Naba core matrisome
Mediation Categories
Other mediation
Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
ecm_regulatorecm_regulatorMatrisomeYes
ecm_regulatorecm_regulatorOmniPathYes

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometryWestern blotting439290459315085003372925530760538
Sequence, Structure & Domains

Sequences

Length
339
Mass
36,985
Sequence
MTARAFWLLCLIVGSSPEAPVAERKTSPPHSRKPDSRGCPSAEETPGPRAQPLLEAPQRPRAAEVAPAARAWPDPRRRKPPPPADNQASFREAARAPAGPPGPRLAQAENRASPRREPASEDAPRRARSRALRFPAARPPALATEGSAGHAHPNRPRAAALAPGPAPAPPPRFSLSFGLSPPQRDAEPGAEPCARACRSDLDEREAFCESEFAVNGIVHDVDVLGAGIRLVTLLVDRDGLYKMNRLYLTPDGFFFRVHMLALDSSSCNKPCPEFKPGSRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q2M2W7-1; Sequence=Displayed; Name=2; IsoId=Q2M2W7-2; Sequence=VSP_036597
Alternative Sequence
278..339; SRYIVMGHIYHKRRQLPTALLQVLRGRLRPGDGLLRSSSSYVKRFNRKREGQIQGAIHTQCI -> IETDLNDAAYVLYTTVCNVGATARAVGRPAFFWERWGTMT (in isoform 2)

Domain & Motif Annotations

Compositional Bias
21..36; Basic and acidic residues; 56..72; Low complexity; 112..125; Basic and acidic residues; 132..163; Low complexity
Domain (FT)
193..338; NTR
Region
17..191; Disordered
Protein Families
UPF0450 family
Sequence Similarities
Belongs to the UPF0450 family.
Clinical Relevance
Antibody
HPA023036
Supporting Publications1
PMIDTitleRelated sentences
38113368In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.No related sentences available