Protein detail
TM266
Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1)
Entry name TM266 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification Predicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Transmembrane protein 266 (hTMEM266) (HV1-related protein 1) (HsHVRP1)
Protein Class
Predicted membrane proteins
Transmembrane
95..115; Helical; Name=Segment S1; 122..142; Helical; Name=Segment S2; 162..182; Helical; Name=Segment S3; 192..212; Helical; Name=Segment S4
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
C15orf27FLJ38190
Gene Description
Transmembrane protein 266
Chromosome
15
Position
76059958-76229121
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificColonocytesBlood Cell SpecificbasophilBlood Lineage Specificdendritic cells
Function & Pathway5
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Canonical Pathways (3)
- M18895 Sa trka receptor
- M271 Pid pi3k plc trk pathway
- M100 Pid shp2 pathway
Mediation Categories
Other mediation
Relations & Evidence13
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMicrofluidics-Based Methods | Mass spectrometry | 13 | 39290459315085003822545340545963394435443055028741197617376863663849095841201090379223003983538640091455 |
Sequence, Structure & Domains7
Sequences
Length
523
Mass
57,626
Sequence
MTNPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTAGSQLLSNLDEDYQREGSNWLKPCCGKRAAVWQVFLLSASLNSFLVACVILVVILLTLELLIDIKLLQFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMLRIWRVKRVIDAYVLPVKLEMEMVIQQYEKAKVIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRFKVLEAGTWDEETAAESVVEELQPSQEATMKDDMNSYISQYYNGPSSDSGVPEPAVCMVTTAAIDIHQPNISSDLFSLDMPLKLGGNGTSATSESASRSSVTRAQSDSSQTLGSSMDCSTAREEPSSEPGPSPPPLPSQQQVEEATVQDLLSSLSEDPCPSQKALDPAPLARPSPAGSAQTSPELEHRVSLFNQKNQEGFTVFQIRPVIHFQPTVPMLEDKFRSLESKEQKLHRVPEA
Domain & Motif Annotations
Compositional Bias
374..389; Low complexity; 390..403; Polar residues; 413..422; Pro residues
Coiled Coil
218..270
Domain (CC)
The transmembrane segment S4 functions as a voltage-sensor and is characterized by a series of positively charged amino acids at every third position (PubMed:30810529). Transplantation of the transmembrane segment S4 into HVCN1, generates a functional voltage-activated proton channel (PubMed:30810529).; DOMAIN: The coiled coil mediates homodimerization.
Region
372..469; Disordered
Clinical Relevance4
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No abstract available |