Protein detail
PARP6
Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)
Entry name PARP6 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Metabolic proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)
Protein Class
Metabolic proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ARTD17pART17
Gene Description
Poly(ADP-ribose) polymerase family member 6
Chromosome
15
Position
72241181-72272999
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly spermatids
Function & Pathway
Protein Function
Predicted intracellular proteins
Molecular Function
- GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity
- GO:0016779 nucleotidyltransferase activity
- GO:0019900 kinase binding
- GO:0043539 protein serine/threonine kinase activator activity
- GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity
- GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity
Biological Process
Reactome
- R-hsa-5663205 infectious disease
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-9683610 maturation of sars cov 1 nucleoprotein
- R-hsa-9694631 maturation of sars cov 2 nucleoprotein
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-196807 nicotinate metabolism
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9683701 translation of sars cov 1 structural proteins
- R-hsa-9694635 translation of sars cov 2 structural proteins
- R-hsa-9824446 viral infection pathways
Mediation Categories
Clinical-translation mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
630
Mass
71,115
Sequence
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PARP6-FL; IsoId=Q2NL67-1; Sequence=Displayed; Name=2; Synonyms=PARP6-S; IsoId=Q2NL67-2; Sequence=VSP_020965, VSP_020966; Name=3; IsoId=Q2NL67-3; Sequence=VSP_020963, VSP_020964
Alternative Sequence
373..388; NPKKKNYERLQKALDS -> MVELDPRTTPHSDGPD (in isoform 3); 389..630; Missing (in isoform 3); 498..518; LHGAAYGKGIYLSPISSISFG -> EWEKDSTGCPPRMSWSRDTTG (in isoform 2); 519..630; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (FT)
394..620; PARP catalytic
Protein Families
ARTD/PARP family
Sequence Similarities
Belongs to the ARTD/PARP family.
Clinical Relevance
Antibody