Protein detail
PARP6
Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)
Entry name PARP6 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Metabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Protein mono-ADP-ribosyltransferase PARP6 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 17) (ARTD17) (Poly [ADP-ribose] polymerase 6) (PARP-6)
Protein Class (2)
Metabolic proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
ARTD17pART17
Gene Description
Poly(ADP-ribose) polymerase family member 6
Chromosome
15
Position
72241181-72272999
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization3
Tissue SpecifictestisCell SpecificEarly spermatids
Function & Pathway6
Protein Function
Predicted intracellular proteins
Cellular Component (2)
Molecular Function (6)
- GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity
- GO:0016779 nucleotidyltransferase activity
- GO:0019900 kinase binding
- GO:0043539 protein serine/threonine kinase activator activity
- GO:0140803 NAD+-protein-cysteine ADP-ribosyltransferase activity
- GO:0140806 NAD+-protein-aspartate ADP-ribosyltransferase activity
Biological Process (3)
Reactome (13)
- R-hsa-5663205 infectious disease
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-9683610 maturation of sars cov 1 nucleoprotein
- R-hsa-9694631 maturation of sars cov 2 nucleoprotein
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-196807 nicotinate metabolism
- R-hsa-9678108 sars cov 1 infection
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
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Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence4
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Sequence, Structure & Domains8
Sequences
Length
630
Mass
71,115
Sequence
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=PARP6-FL; IsoId=Q2NL67-1; Sequence=Displayed; Name=2; Synonyms=PARP6-S; IsoId=Q2NL67-2; Sequence=VSP_020965, VSP_020966; Name=3; IsoId=Q2NL67-3; Sequence=VSP_020963, VSP_020964
Alternative Sequence
373..388; NPKKKNYERLQKALDS -> MVELDPRTTPHSDGPD (in isoform 3); 389..630; Missing (in isoform 3); 498..518; LHGAAYGKGIYLSPISSISFG -> EWEKDSTGCPPRMSWSRDTTG (in isoform 2); 519..630; Missing (in isoform 2)
Domain & Motif Annotations
Domain (FT)
394..620; PARP catalytic
Protein Families
ARTD/PARP family
Sequence Similarities
Belongs to the ARTD/PARP family.
Clinical Relevance1
Antibody
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No abstract available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No abstract available |