Protein detail

LIN41

E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)

Entry name
LIN41
UniProt ID
Q2Q1W2
EVMP score
0.38
Frequency
2
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)
Protein Class
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteins
Protein Function
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
  • Enzymes
  • Disease related genes
Ensembl
ENSG00000206557
Entrez Gene Symbol
TRIM71
Gene Synonym
LIN-41LIN41
Gene Description
Tripartite motif containing 71
Chromosome
3
Position
32817997-32897824
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
  • Enzymes
  • Disease related genes
Cellular Component
GO:0000932 P-body
Molecular Function
Biological Process
KEGG
hsa05206 MicroRNAs in cancer
Reactome
Mediation Categories
Immune mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
TRIM71PRKACAP17612S3phosphorylationPhosphoSite

Ligand-Receptor Signaling

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo

Regulatory Interaction Network

139 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
LIN41Q2Q1W2LN28BQ6ZN17YesNoYesHINTSIGNORSIGNOR:24602972HINT:33961781HINT:24602972
LIN41Q2Q1W2P53P04637YesNoYesSIGNORSIGNOR:28430184
COMPLEX:P62987_Q9Y385LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P0CG47_P60604LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P62253_P62987LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P62987_Q13404LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P62987_Q16763LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P0CG47_P62256LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P0CG48_Q13404LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
COMPLEX:P0CG48_Q96B02LIN41Q2Q1W2YesYesNoSIGNORSIGNOR:34199813
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Protein Complex Composition

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
Ub:RING_E3TRIM71UBBP0CG47Q2Q1W20:0SIGNORSIGNOR:SIGNOR-C519
Ub:RING_E3TRIM71UBCP0CG48Q2Q1W20:0SIGNORSIGNOR:SIGNOR-C519
Ub:RING_E3RPS27ATRIM71P62979Q2Q1W20:0SIGNORSIGNOR:SIGNOR-C519
Ub:RING_E3TRIM71UBA52P62987Q2Q1W20:0SIGNORSIGNOR:SIGNOR-C519
TRIM71Q2Q1W22PDBPDB:7qrx

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Mass spectrometry0
Sequence, Structure & Domains

Sequences

Length
868
Mass
93,385
Sequence
MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF

3D Structural Models

Turn
766..769
Helix
625..627; 672..674; 719..721; 741..747; 813..815; 860..862
Beta Strand
593..596; 606..608; 612..614; 620..624; 629..633; 639..643; 646..649; 653..661; 667..671; 676..680; 686..690; 693..696; 700..708; 714..718; 723..727; 733..738; 750..755; 761..765; 770..774; 781..784; 787..790; 794..802; 808..812; 817..821; 827..831; 834..837; 841..849; 855..859; 864..868
3D Structure
X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias
26..41; Low complexity; 147..158; Basic residues; 165..176; Pro residues; 177..189; Low complexity
Repeat
479..580; Filamin; 593..636; NHL 1; 640..683; NHL 2; 687..730; NHL 3; 734..777; NHL 4; 781..824; NHL 5; 828..868; NHL 6
Coiled Coil
391..427
Zinc Finger
12..95; RING-type; 194..241; B box-type 1; atypical; 273..314; B box-type 2
Domain (CC)
The NHL domain, containing the 6 NHL repeats, is necessary and sufficient to target RNA but not to repress mRNA. The minimal region needed to execute repression consists of the coiled coil domain and the Filamin repeat. The RING-type domain is dispensable for mRNA repression.
Region
26..49; Disordered; 127..189; Disordered
Protein Families
TRIM/RBCC family
Sequence Similarities
Belongs to the TRIM/RBCC family.
Clinical Relevance
Disease Involvement
Disease variant
Antibody
HPA038141HPA038142