Protein detail
KIF19
Kinesin-like protein KIF19
Entry name KIF19 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Kinesin-like protein KIF19
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FLJ37300KIF19A
Gene Description
Kinesin family member 19
Chromosome
17
Position
74326210-74355820
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecifictestisBrain Regional Specificcerebral cortexCell SpecificEarly spermatidsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway8
Protein Function
Predicted intracellular proteins
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Reactome (8)
- R-hsa-6811434 copi dependent golgi to er retrograde traffic
- R-hsa-983231 factors involved in megakaryocyte development and platelet production
- R-hsa-8856688 golgi to er retrograde transport
- R-hsa-109582 hemostasis
- R-hsa-6811442 intra golgi and retrograde golgi to er traffic
- R-hsa-983189 kinesins
- R-hsa-199991 membrane trafficking
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways (2)
- M17 Pid notch pathway
- M48 Pid met pathway
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence5
Ligand-Receptor Signaling (3)
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryR Sequencing | 14 | 3820710640189497381133683330447832854315409404493447350537563857329169864130796836146834318059583344194939207047 |
Sequence, Structure & Domains11
Sequences
Length
998
Mass
111,332
Sequence
MKDSGDSKDQQLMVALRVRPISVAELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDQEPGIYVQTLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPSLGYLELREDSKGVIQVAGITEVSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVTVRQRSRVKNILQEVRQGRLFMIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGSNKYINYRDSKLTRLLKDSLGGNSRTVMIAHISPASSAFEESRNTLTYAGRAKNIKTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKRKIDEQTGRGQARGRQDRGDIRHIQAEVQLHSGQGEKAGMGQLREQLASAFQEQMDVRRRLLELENRAMEVQIDTSRHLLTIAGWKHEKSRRALKWREEQRKECYAKDDSEKDSDTGDDQPDILEPPEVAAARESIAALVDEQKQLRKQKLALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLLCRVHELEVENTEMQSHALLRDGALRHRHEAVRRLEQHRSLCDEIIQGQRQIIDDYNLAVPQRLEELYEVYLRELEEGSLEQATIMDQVASRALQDSSLPKITPAGTSLTPDSDLESVKTLSSDAQHLQNSALPPLSTESEGHHVFKAGTGAWQAKSSSVPTPPPIQLGSLVTQEAPAQDSLGSWINSSPDSSENLSEIPLSHKERKEILTGTKCIWVKAARRRSRALGTEGRHLLAPATERSSLSLHSLSEGDDARPPGPLACKRPPSPTLQHAASEDNLSSSTGEAPSRAVGHHGDGPRPWLRGQKKSLGKKREESLEAKRRKRRSRSFEVTGQGLSHPKTHLLGPHQAERISDHRMPVCRHPAPGIRHLGKVTLPLAKVKLPPSQNTGPGDSSPLAVPPNPGGGSRRATRGPRLPHGTSTHGKDGCSRHN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2TAC6-1; Sequence=Displayed; Name=2; IsoId=Q2TAC6-2; Sequence=VSP_023208, VSP_023209; Name=3; IsoId=Q2TAC6-3; Sequence=VSP_023207, VSP_023208, VSP_023209
Alternative Sequence
152..193; Missing (in isoform 3); 530..548; LALEQRCRELRARGRRLEE -> VSRVWGDKESGFRGQGEQV (in isoform 2 and isoform 3); 549..998; Missing (in isoform 2 and isoform 3)
Domain & Motif Annotations
Compositional Bias
482..494; Basic and acidic residues; 662..676; Polar residues; 684..697; Polar residues; 746..761; Polar residues; 836..852; Polar residues; 989..998; Basic and acidic residues
Coiled Coil
360..391; 424..452; 507..552
Domain (FT)
11..346; Kinesin motor
Region
482..503; Disordered; 662..706; Disordered; 746..765; Disordered; 794..911; Disordered; 948..998; Disordered
Protein Families (2)
- TRAFAC class myosin-kinesin ATPase superfamily
- Kinesin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37595532 | Exosomes from hypoxia-conditioned apical papilla stem cells accelerate angiogenesis in vitro through Notch/JAG1/VEGF signaling. | Interestingly, we found that the hypoxia inducible factor-1α (HIF-1α)/Notch1 signaling pathway was activated in hypoxic SCAPs, and protein jagged-1 (JAG1) was delivered by hypoxic SCAPs-derived exosomes to increase vascular endothelial growth factor (VEGF) production in HUVECs. |