Protein detail
KIF19
Kinesin-like protein KIF19
Protein symbol KIF19 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Kinesin-like protein KIF19
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ37300KIF19A
Gene Description
Kinesin family member 19
Chromosome
17
Position
74326210-74355820
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecifictestisBrain Regional Specificcerebral cortexCell SpecificEarly spermatidsSingle-Nuclei Brain Specificcentral nervous system macrophage
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-6811434 copi dependent golgi to er retrograde traffic
- R-hsa-983231 factors involved in megakaryocyte development and platelet production
- R-hsa-8856688 golgi to er retrograde transport
- R-hsa-109582 hemostasis
- R-hsa-6811442 intra golgi and retrograde golgi to er traffic
- R-hsa-983189 kinesins
- R-hsa-199991 membrane trafficking
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
- M17 Pid notch pathway
- M48 Pid met pathway
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity Capture | Mass spectrometryR Sequencing | 14 | 3820710640189497381133683330447832854315409404493447350537563857329169864130796836146834318059583344194939207047 |
Sequence, Structure & Domains
Sequences
Length
998
Mass
111,332
Sequence
MKDSGDSKDQQLMVALRVRPISVAELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDQEPGIYVQTLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLNPSLGYLELREDSKGVIQVAGITEVSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVTVRQRSRVKNILQEVRQGRLFMIDLAGSERASQTQNRGQRMKEGAHINRSLLALGNCINALSDKGSNKYINYRDSKLTRLLKDSLGGNSRTVMIAHISPASSAFEESRNTLTYAGRAKNIKTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKRKIDEQTGRGQARGRQDRGDIRHIQAEVQLHSGQGEKAGMGQLREQLASAFQEQMDVRRRLLELENRAMEVQIDTSRHLLTIAGWKHEKSRRALKWREEQRKECYAKDDSEKDSDTGDDQPDILEPPEVAAARESIAALVDEQKQLRKQKLALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLLCRVHELEVENTEMQSHALLRDGALRHRHEAVRRLEQHRSLCDEIIQGQRQIIDDYNLAVPQRLEELYEVYLRELEEGSLEQATIMDQVASRALQDSSLPKITPAGTSLTPDSDLESVKTLSSDAQHLQNSALPPLSTESEGHHVFKAGTGAWQAKSSSVPTPPPIQLGSLVTQEAPAQDSLGSWINSSPDSSENLSEIPLSHKERKEILTGTKCIWVKAARRRSRALGTEGRHLLAPATERSSLSLHSLSEGDDARPPGPLACKRPPSPTLQHAASEDNLSSSTGEAPSRAVGHHGDGPRPWLRGQKKSLGKKREESLEAKRRKRRSRSFEVTGQGLSHPKTHLLGPHQAERISDHRMPVCRHPAPGIRHLGKVTLPLAKVKLPPSQNTGPGDSSPLAVPPNPGGGSRRATRGPRLPHGTSTHGKDGCSRHN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q2TAC6-1; Sequence=Displayed; Name=2; IsoId=Q2TAC6-2; Sequence=VSP_023208, VSP_023209; Name=3; IsoId=Q2TAC6-3; Sequence=VSP_023207, VSP_023208, VSP_023209
Alternative Sequence
152..193; Missing (in isoform 3); 530..548; LALEQRCRELRARGRRLEE -> VSRVWGDKESGFRGQGEQV (in isoform 2 and isoform 3); 549..998; Missing (in isoform 2 and isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
482..494; Basic and acidic residues; 662..676; Polar residues; 684..697; Polar residues; 746..761; Polar residues; 836..852; Polar residues; 989..998; Basic and acidic residues
Coiled Coil
360..391; 424..452; 507..552
Domain (FT)
11..346; Kinesin motor
Region
482..503; Disordered; 662..706; Disordered; 746..765; Disordered; 794..911; Disordered; 948..998; Disordered
Protein Families
- TRAFAC class myosin-kinesin ATPase superfamily
- Kinesin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.