Protein detail

RMP24

Ribonuclease MRP protein subunit p24 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) (Ribonuclease MRP subunit p24) (UPF0711 protein C18orf21)

Entry name RMP24	UniProt ID Q32NC0	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Essential proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Ribonuclease MRP protein subunit p24 (HBV X-transactivated gene 13 protein) (HBV XAg-transactivated protein 13) (Ribonuclease MRP subunit p24) (UPF0711 protein C18orf21)

Protein Class (2)

Essential proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000141428

Entrez Gene Symbol

C18orf21

Gene Synonym (3)

HsT3108PNAS-124PNAS-131

Gene Description

Chromosome 18 open reading frame 21

Chromosome

Position

35972625-35979286

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway3

Protein Function

Predicted intracellular proteins

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (4)

4 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
C18orf21 NEPRO POP4 POP5 POP7 RPP14 RPP21 RPP25 RPP25L RPP30 RPP38 RPP40	O75817 O75818 O95059 O95707 P78345 P78346 Q32NC0 Q6NW34 Q8N5L8 Q969H6 Q9BUL9 Q9H633	0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
C18orf21 NEPRO POP4 POP5 POP7 RPP14 RPP25 RPP30 RPP38 RPP40	O75817 O75818 O95059 O95707 P78345 P78346 Q32NC0 Q6NW34 Q969H6 Q9BUL9	0:0:0:0:0:0:0:0:0:0	hu.MAP
C18orf21 NEPRO POP4 POP5 POP7 RPP14 RPP21 RPP25 RPP30 RPP38 RPP40	O75817 O75818 O95059 O95707 P78345 P78346 Q32NC0 Q6NW34 Q969H6 Q9BUL9 Q9H633	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
C18orf21 POP4 RPP30 RPP38	O95707 P78345 P78346 Q32NC0	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometryELISA	2	40784529 40091455

Sequence, Structure & Domains9

Sequences

Length

220

Mass

24,827

Sequence

MRQKHYLEAAARGLHDSCPGQARYLLWAYTSSHDDKSTFEETCPYCFQLLVLDNSRVRLKPKARLTPKIQKLLNREARNYTLSFKEAKMVKKFKDSKSVLLITCKTCNRTVKHHGKSRSFVSTLKSNPATPTSKLSLKTPERRTANPNHDMSGSKGKSPASVFRTPTSGQSVSTCSSKNTSKTKKHFSQLKMLLSQNESQKIPKVDFRNFLSSLKGGLLK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q32NC0-1; Sequence=Displayed; Name=2; IsoId=Q32NC0-2; Sequence=VSP_055184

Alternative Sequence

1..88; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

119..136; Polar residues; 171..180; Low complexity

Region

117..181; Disordered

Protein Families

RMP24 family

Sequence Similarities

Belongs to the RMP24 family.

Clinical Relevance2

Drugs (4)

QUINIDINE DOFETILIDE SOTALOL IBUTILIDE

Antibody (2)

HPA065505 HPA067322

Supporting Publications2

PMID	Title	Abstract
38576002	Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation.	No abstract available
38795909	Proteomic profile of tissue-derived extracellular vesicles from benign odontogenic lesions.	No abstract available