Protein detail
PLPR5
Phospholipid phosphatase-related protein type 5 (Lipid phosphate phosphatase-related protein type 5) (Phosphatidic acid phosphatase type 2d) (Plasticity-related gene 5 protein) (PRG-5)
Entry name PLPR5 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 6 | Protein classification Predicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Phospholipid phosphatase-related protein type 5 (Lipid phosphate phosphatase-related protein type 5) (Phosphatidic acid phosphatase type 2d) (Plasticity-related gene 5 protein) (PRG-5)
Protein Class
Predicted membrane proteins
Transmembrane
10..30; Helical; 62..82; Helical; 122..142; Helical; 196..213; Helical; 225..245; Helical; 252..272; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
LPPR5PAP2PAP2DPRG5
Gene Description
Phospholipid phosphatase related 5
Chromosome
1
Position
98890245-99227929
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly primary spermatocytesSecretome LocationIntracellular and membraneSecretome FunctionNo annotated function
Function & Pathway
Cellular Component
Molecular Function
Biological Process (3)
Reactome (4)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence12
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | ||||
| cell_surface_enzyme | cell_surface_enzyme | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath |
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Sequence, Structure & Domains
Sequences
Length
321
Mass
35,427
Sequence
MPLLPAALTSSMLYFQMVIMAGTVMLAYYFEYTDTFTVNVQGFFCHDSAYRKPYPGPEDSSAVPPVLLYSLAAGVPVLVIIVGETAVFCLQLATRDFENQEKTILTGDCCYINPLVRRTVRFLGIYTFGLFATDIFVNAGQVVTGNLAPHFLALCKPNYTALGCQQYTQFISGEEACTGNPDLIMRARKTFPSKEAALSVYAAMYLTMYITNTIKAKGTRLAKPVLCLGLMCLAFLTGLNRVAEYRNHWSDVIAGFLVGISIAVFLVVCVVNNFKGRQAENEHIHMDNLAQMPMISIPRVESPLEKVTSVQNHITAFAEVT
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PAP2d_v1; IsoId=Q32ZL2-1; Sequence=Displayed; Name=2; Synonyms=PAP2d_v2; IsoId=Q32ZL2-2; Sequence=VSP_031828
Alternative Sequence
307..311; Missing (in isoform 2)
Domain & Motif Annotations
Protein Families
PA-phosphatase related phosphoesterase family
Sequence Similarities
Belongs to the PA-phosphatase related phosphoesterase family.
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No related sentences available |