Protein detail

ASTRB

Protein Aster-B (GRAM domain-containing protein 1B)

Entry name ASTRB	UniProt ID Q3KR37	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Predicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Aster-B (GRAM domain-containing protein 1B)

Protein Class (3)

Predicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters
Predicted intracellular proteins

Transmembrane

623..643; Helical

Transmembrane Count

Ensembl

ENSG00000023171

Entrez Gene Symbol

GRAMD1B

Gene Synonym (2)

KIAA1201LINC01059

Gene Description

GRAM domain containing 1B

Chromosome

Position

123358428-123627774

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue SpecificbrainCell SpecificEndometrial ciliated cells

Function & Pathway5

Protein Function (2)

Transporters
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence18

Ligand-Receptor Signaling (14)

14 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Protein Complex Composition (3)

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
EFCAB14 GOLM2 GRAMD1B GRAMD2B	O75071 Q3KR37 Q6P4E1 Q96HH9	0:0:0:0	hu.MAP
EFCAB14 EXD2 GRAMD1B GRAMD2B	O75071 Q3KR37 Q96HH9 Q9NVH0	0:0:0:0	hu.MAP
GRAMD1B GRAMD2B	Q3KR37 Q96HH9	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Data-Dependent Acquisition LC-MS/MS	1	32795414

Sequence, Structure & Domains9

Sequences

Length

738

Mass

85,400

Sequence

MKGFKLSCTASNSNRSTPACSPILRKRSRSPTPQNQDGDTMVEKGSDHSSDKSPSTPEQGVQRSCSSQSGRSGGKNSKKSQSWYNVLSPTYKQRNEDFRKLFKQLPDTERLIVDYSCALQRDILLQGRLYLSENWICFYSNIFRWETLLTVRLKDICSMTKEKTARLIPNAIQVCTDSEKHFFTSFGARDRTYMMMFRLWQNALLEKPLCPKELWHFVHQCYGNELGLTSDDEDYVPPDDDFNTMGYCEEIPVEENEVNDSSSKSSIETKPDASPQLPKKSITNSTLTSTGSSEAPVSFDGLPLEEEALEGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDEGEVQAFYEDLSGRQYVNEVFNFSVDKLYDLLFTNSPFQRDFMEQRRFSDIIFHPWKKEENGNQSRVILYTITLTNPLAPKTATVRETQTMYKASQESECYVIDAEVLTHDVPYHDYFYTINRYTLTRVARNKSRLRVSTELRYRKQPWGLVKTFIEKNFWSGLEDYFRHLESELAKTESTYLAEMHRQSPKEKASKTTTVRRRKRPHAHLRVPHLEEVMSPVTTPTDEDVGHRIKHVAGSTQTRHIPEDTPNGFHLQSVSKLLLVISCVICFSLVLLVILNMMLFYKLWMLEYTTQTLTAWQGLRLQERLPQSQTEWAQLLESQQKYHDTELQKWREIIKSSVMLLDQMKDSLINLQNGIRSRDYTSESEEKRNRYH

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q3KR37-1; Sequence=Displayed; Name=2; IsoId=Q3KR37-2; Sequence=VSP_025470; Name=3; IsoId=Q3KR37-3; Sequence=VSP_025469, VSP_025471, VSP_025472; Name=4; IsoId=Q3KR37-4; Sequence=VSP_057573

Alternative Sequence

1..309; Missing (in isoform 3); 1..40; Missing (in isoform 2); 78; K -> KSHKRLSK (in isoform 4); 310..361; EGDGSLEKELAIDNIMGEKIEMIAPVNSPSLDFNDNEDIPTELSDSSDTHDE -> MPTSSAVLLRVLSIPLLTVLILARDLSALGGCPWGPLPLRCHCLLPDPLFCA (in isoform 3); 631..634; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

8..19; Polar residues; 41..51; Basic and acidic residues; 59..70; Low complexity; 259..268; Polar residues; 281..295; Polar residues; 545..556; Basic and acidic residues

Domain (CC)

GRAM domain binds phosphatidylserine in the PM and mediates protein recruitment to endoplasmic reticulum-plasma membrane contact sites (EPCS) in response to excess cholesterol in the PM.; DOMAIN: VASt (VAD1 Analog of StAR-related lipid transfer) domain, also known as ASTER (Greek for star) domain is a sterol-binding domain.

Domain (FT)

96..163; GRAM; 372..543; VASt

Region

1..81; Disordered; 254..301; Disordered; 544..566; Disordered

Clinical Relevance5

Drugs

LITHIUM

Antibody (2)

HPA008557 HPA075204

Interaction Protein (2)

ENSG00000070770ENSG00000101266

Interaction Count

Interaction Dataset

biogrid_opencell

Supporting Publications1

PMID	Title	Abstract
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available