Protein detail
PKHN1
Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)
Entry name PKHN1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
DKFZP434H2010
Gene Description
Pleckstrin homology domain containing N1
Chromosome
1
Position
966482-975865
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificLate spermatids
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
611
Mass
66,409
Sequence
MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAARSGDAAANKLFHYIPGTDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKVQLRFQHSQDVSDCYLELFPAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQITGPLPAPLLVLCPSRAELDRWLYHLEKQTALLGGPRRCHSAPPQRRLTRLRTASGHEPGGSAVCASRVKLQHLPAQEQWDRLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLEEKEKQIRSFLIEGPLINTIRVVCASYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQVMGSGRGSLSSGGQTSWDSGCLAPPSTRTSHSLPESSVPSTVGCSSQHTPDQANSDRASIGRRRTELRRSGSSRSPGSKARAEGRGPVTPLHLDLTQLHRLSLESSPDAPDHTSETSHSPLYADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDPRSCSSGPAGPYLLSKKGALQSRAAQRHRGSAKDGGPQPPDAPQLVSSAREGSPEPWLPLTDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGGPEASGGLVQWI
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q494U1-1; Sequence=Displayed; Name=2; IsoId=Q494U1-2; Sequence=VSP_059838, VSP_059839; Name=3; IsoId=Q494U1-3; Sequence=VSP_059839, VSP_059840
Alternative Sequence
162; G -> GVWDASRAPRGTPDPGLGEGPALWLRSTCVYVCALSALPAG (in isoform 2); 204; Q -> QGSCGDELPWTLQ (in isoform 2 and isoform 3); 385..431; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
341..350; Low complexity; 360..391; Polar residues; 498..509; Low complexity; 570..585; Basic and acidic residues
Domain (CC)
Both PH domains are essential for its mitochondrial localization.
Domain (FT)
96..192; PH 1; 222..319; PH 2
Region
1..45; Disordered; 61..100; Interaction with C1QBP; 323..424; Disordered; 438..468; Disordered; 483..611; Disordered