Protein detail

PKHN1

Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)

Entry name PKHN1	UniProt ID Q494U1	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000187583

Entrez Gene Symbol

PLEKHN1

Gene Synonym

DKFZP434H2010

Gene Description

Pleckstrin homology domain containing N1

Chromosome

Position

966482-975865

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificLate spermatids

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (5)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (6)

6 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blottingFlow cytometryELISA	6	39290459 33709510 37686366 38321535 35111156 40091455

Sequence, Structure & Domains9

Sequences

Length

611

Mass

66,409

Sequence

MGNSHCVPQAPRRLRASFSRKPSLKGNREDSARMSAGLPGPEAARSGDAAANKLFHYIPGTDILDLENQRENLEQPFLSVFKKGRRRVPVRNLGKVVHYAKVQLRFQHSQDVSDCYLELFPAHLYFQAHGSEGLTFQGLLPLTELSVCPLEGSREHAFQITGPLPAPLLVLCPSRAELDRWLYHLEKQTALLGGPRRCHSAPPQRRLTRLRTASGHEPGGSAVCASRVKLQHLPAQEQWDRLLVLYPTSLAIFSEELDGLCFKGELPLRAVHINLEEKEKQIRSFLIEGPLINTIRVVCASYEDYGHWLLCLRAVTHREGAPPLPGAESFPGSQVMGSGRGSLSSGGQTSWDSGCLAPPSTRTSHSLPESSVPSTVGCSSQHTPDQANSDRASIGRRRTELRRSGSSRSPGSKARAEGRGPVTPLHLDLTQLHRLSLESSPDAPDHTSETSHSPLYADPYTPPATSHRRVTDVRGLEEFLSAMQSARGPTPSSPLPSVPVSVPASDPRSCSSGPAGPYLLSKKGALQSRAAQRHRGSAKDGGPQPPDAPQLVSSAREGSPEPWLPLTDGRSPRRSRDPGYDHLWDETLSSSHQKCPQLGGPEASGGLVQWI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q494U1-1; Sequence=Displayed; Name=2; IsoId=Q494U1-2; Sequence=VSP_059838, VSP_059839; Name=3; IsoId=Q494U1-3; Sequence=VSP_059839, VSP_059840

Alternative Sequence

162; G -> GVWDASRAPRGTPDPGLGEGPALWLRSTCVYVCALSALPAG (in isoform 2); 204; Q -> QGSCGDELPWTLQ (in isoform 2 and isoform 3); 385..431; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

341..350; Low complexity; 360..391; Polar residues; 498..509; Low complexity; 570..585; Basic and acidic residues

Domain (CC)

Both PH domains are essential for its mitochondrial localization.

Domain (FT)

96..192; PH 1; 222..319; PH 2

Region

1..45; Disordered; 61..100; Interaction with C1QBP; 323..424; Disordered; 438..468; Disordered; 483..611; Disordered

Clinical Relevance1

Antibody (2)

HPA031741 HPA031742

Supporting Publications1

PMID	Title	Abstract
38014595	Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.	No abstract available