Protein detail
TPRN
Taperin
Entry name TPRN | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Taperin
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym
C9orf75DFNB79FLJ90254
Gene Description
Taperin
Chromosome
9
Position
137191617-137204193
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Other mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
5 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Data-Dependent Acquisition LC-MS/MS | 1 | 32795414 |
Sequence, Structure & Domains
Sequences
Length
711
Mass
75,556
Sequence
MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4KMQ1-1; Sequence=Displayed; Name=2; IsoId=Q4KMQ1-2; Sequence=VSP_033027; Name=3; IsoId=Q4KMQ1-3; Sequence=VSP_033027, VSP_033028; Name=4; IsoId=Q4KMQ1-4; Sequence=VSP_039038, VSP_039039
Alternative Sequence
1..306; Missing (in isoform 2 and isoform 3); 1..305; Missing (in isoform 4); 306..311; VMETIP -> MVSITG (in isoform 4); 691; M -> MVRCGGVERWGESDTRASPCVHILSSHFQ (in isoform 3)
3D Structural Models
Helix
458..460
Beta Strand
455..457
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
157..180; Pro residues; 197..206; Polar residues; 267..282; Low complexity; 283..296; Polar residues; 512..521; Polar residues; 581..590; Polar residues; 597..624; Acidic residues
Region
134..305; Disordered; 328..384; Disordered; 414..438; Disordered; 500..535; Disordered; 572..630; Disordered; 642..662; Disordered; 674..711; Disordered
Protein Families
Taperin family
Sequence Similarities
Belongs to the taperin family.