Protein detail

TPRN

Taperin

Entry name
TPRN
UniProt ID
Q4KMQ1
EVMP confidence score
0.28
Supporting publications (n)
2
Transmembrane count
Protein classification
Disease related genesHuman disease related genesPredicted intracellular proteins
Basic Information
Protein Names
Taperin
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Ear disease
Ensembl
ENSG00000176058
Entrez Gene Symbol
TPRN
Gene Synonym (3)
C9orf75DFNB79FLJ90254
Gene Description
Taperin
Chromosome
9
Position
137191617-137204193
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
TPRN fluorescence
Tissue Specificadrenal glandCell SpecificAdrenal cortex cells
Function & Pathway
Protein Function (3)
  • Disease related genes
  • Predicted intracellular proteins
  • Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
Reactome (3)
Mediation Categories
Other mediation
Relations & Evidence10

Ligand-Receptor Signaling (4)

4 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularUniProt_location
intracellularintracellularOmniPath

Protein Complex Composition (5)

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
PLA2G7PTPRNQ13093Q168490:0hu.MAP
PLA2G7PTPRNPTPRN2Q13093Q16849Q929320:0:0hu.MAP2
PTPRNQ168492PDBPDB:3np5PDB:3n01PDB:3n4wPDB:2i1yPDB:2qt7PDB:3ng8
PTPRNPTPRN2Q16849Q929320:0hu.MAP2
PTPRN2Q929322PDBPDB:2qep

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationData-Dependent Acquisition LC-MS/MS132795414
Sequence, Structure & Domains

Sequences

Length
711
Mass
75,556
Sequence
MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4KMQ1-1; Sequence=Displayed; Name=2; IsoId=Q4KMQ1-2; Sequence=VSP_033027; Name=3; IsoId=Q4KMQ1-3; Sequence=VSP_033027, VSP_033028; Name=4; IsoId=Q4KMQ1-4; Sequence=VSP_039038, VSP_039039
Alternative Sequence
1..306; Missing (in isoform 2 and isoform 3); 1..305; Missing (in isoform 4); 306..311; VMETIP -> MVSITG (in isoform 4); 691; M -> MVRCGGVERWGESDTRASPCVHILSSHFQ (in isoform 3)

3D Structural Models

Helix
458..460
Beta Strand
455..457
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias
157..180; Pro residues; 197..206; Polar residues; 267..282; Low complexity; 283..296; Polar residues; 512..521; Polar residues; 581..590; Polar residues; 597..624; Acidic residues
Region
134..305; Disordered; 328..384; Disordered; 414..438; Disordered; 500..535; Disordered; 572..630; Disordered; 642..662; Disordered; 674..711; Disordered
Protein Families
Taperin family
Sequence Similarities
Belongs to the taperin family.
Clinical Relevance
Disease Involvement (2)
DeafnessNon-syndromic deafness
Related Diseases (2)
DeafnessNon-syndromic deafness
Antibody (2)
HPA020899HPA076667
Interaction Protein (2)
ENSG00000172531ENSG00000213639
Interaction Count
2
Interaction Dataset (2)
intact_biogrid_bioplexbiogrid_bioplex
Supporting Publications2
PMIDTitleRelated sentences
27821849Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.No related sentences available
38716512Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.No related sentences available