Protein detail

TPRN

Taperin

Entry name TPRN	UniProt ID Q4KMQ1	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Taperin

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Ensembl

ENSG00000176058

Entrez Gene Symbol

TPRN

Gene Synonym (3)

C9orf75DFNB79FLJ90254

Gene Description

Taperin

Chromosome

Position

137191617-137204193

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Tissue Specificadrenal glandCell SpecificAdrenal cortex cells

Function & Pathway6

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Cellular Component (5)

Molecular Function (5)

Biological Process (3)

Reactome (3)

Mediation Categories

Other mediation

Relations & Evidence10

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
PLA2G7 PTPRN	Q13093 Q16849	0:0	hu.MAP
PLA2G7 PTPRN PTPRN2	Q13093 Q16849 Q92932	0:0:0	hu.MAP2
PTPRN	Q16849	2	PDB	PDB:3np5PDB:3n01PDB:3n4wPDB:2i1yPDB:2qt7PDB:3ng8
PTPRN PTPRN2	Q16849 Q92932	0:0	hu.MAP2
PTPRN2	Q92932	2	PDB	PDB:2qep

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Data-Dependent Acquisition LC-MS/MS	1	32795414

Sequence, Structure & Domains12

Sequences

Length

711

Mass

75,556

Sequence

MAALGRPGSGPRAAVPAWKREILERKRAKLAALGGGAGPGAAEPEQRVLAESLGPLRENPFMLLEAERRRGGGAAGARLLERYRRVPGVRALRADSVLIIETVPGFPPAPPAPGAAQIRAAEVLVYGAPPGRVSRLLERFDPPAAPRRRGSPERARPPPPPPPPAPPRPPPAAPSPPAAPGPRGGGASPGARRSDFLQKTGSNSFTVHPRGLHRGAGARLLSNGHSAPEPRAGPANRLAGSPPGSGQWKPKVESGDPSLHPPPSPGTPSATPASPPASATPSQRQCVSAATSTNDSFEIRPAPKPVMETIPLGDLQARALASLRANSRNSFMVIPKSKASGAPPPEGRQSVELPKGDLGPASPSQELGSQPVPGGDGAPALGKSPLEVEAQWAVEEGACPRTATALADRAIRWQRPSSPPPFLPAASEEAEPAEGLRVPGLAKNSREYVRPGLPVTFIDEVDSEEAPQAAKLPYLPHPARPLHPARPGCVAELQPRGSNTFTVVPKRKPGTLQDQHFSQANREPRPREAEEEEASCLLGPTLKKRYPTVHEIEVIGGYLALQKSCLTKAGSSRKKMKISFNDKSLQTTFEYPSESSLEQEEEVDQQEEEEEEEEEEEEEEEGSGSEEKPFALFLPRATFVSSVRPESSRLPEGSSGLSSYTPKHSVAFSKWQEQALEQAPREAEPPPVEAMLTPASQNDLSDFRSEPALYF

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4KMQ1-1; Sequence=Displayed; Name=2; IsoId=Q4KMQ1-2; Sequence=VSP_033027; Name=3; IsoId=Q4KMQ1-3; Sequence=VSP_033027, VSP_033028; Name=4; IsoId=Q4KMQ1-4; Sequence=VSP_039038, VSP_039039

Alternative Sequence

1..306; Missing (in isoform 2 and isoform 3); 1..305; Missing (in isoform 4); 306..311; VMETIP -> MVSITG (in isoform 4); 691; M -> MVRCGGVERWGESDTRASPCVHILSSHFQ (in isoform 3)

3D Structural Models

Helix

458..460

Beta Strand

455..457

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

157..180; Pro residues; 197..206; Polar residues; 267..282; Low complexity; 283..296; Polar residues; 512..521; Polar residues; 581..590; Polar residues; 597..624; Acidic residues

Region

134..305; Disordered; 328..384; Disordered; 414..438; Disordered; 500..535; Disordered; 572..630; Disordered; 642..662; Disordered; 674..711; Disordered

Protein Families

Taperin family

Sequence Similarities

Belongs to the taperin family.

Clinical Relevance5

Disease Involvement (2)

DeafnessNon-syndromic deafness

Antibody (2)

HPA020899 HPA076667

Interaction Protein (2)

ENSG00000172531ENSG00000213639

Interaction Count

Interaction Dataset (2)

intact_biogrid_bioplexbiogrid_bioplex

Supporting Publications2

PMID	Title	Abstract
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available