Protein detail
ANO6
Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)
Entry name ANO6 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 10 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Anoctamin-6 (Small-conductance calcium-activated nonselective cation channel) (SCAN channel) (Transmembrane protein 16F)
Protein Class (5)
Disease related genesHuman disease related genesPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
Transmembrane
301..321; Helical; 376..396; Helical; 456..476; Helical; 510..530; Helical; 552..572; Helical; 602..621; Helical; 664..684; Helical; 685..705; Helical; 723..743; Helical; 837..857; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DKFZp313M0720TMEM16F
Gene Description
Anoctamin 6
Chromosome
12
Position
45215987-45482280
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization3
Cell SpecificAstrocytesSingle-Nuclei Brain Specificependymal cell
Function & Pathway7
Protein Function (4)
- Disease related genes
- Transporters:Transporter channels and pores
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Potential drug targets
Cellular Component (8)
Molecular Function (9)
- GO:0005227 calcium-activated cation channel activity
- GO:0005229 intracellularly calcium-gated chloride channel activity
- GO:0005244 voltage-gated monoatomic ion channel activity
- GO:0005247 voltage-gated chloride channel activity
- GO:0005254 chloride channel activity
- GO:0005515 protein binding
- GO:0017128 phospholipid scramblase activity
- GO:0046872 metal ion binding
- GO:0046983 protein dimerization activity
Biological Process (3)
Reactome (11)
- R-hsa-9733458 induction of cell cell fusion
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-983712 ion channel transport
- R-hsa-9772573 late sars cov 2 infection events
- R-hsa-6798695 neutrophil degranulation
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-2672351 stimuli sensing channels
- R-hsa-382551 transport of small molecules
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence25
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| tmem16_phospholipid_scramblase | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | Yes | No |
| transporter | transporter | OmniPath | No | Yes | No | Yes | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
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Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | ELISA | 1 | 26775013 |
Sequence, Structure & Domains7
Sequences
Length
910
Mass
106,165
Sequence
MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSLFFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQEFFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARPEYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGCLLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q4KMQ2-1; Sequence=Displayed; Name=2; IsoId=Q4KMQ2-2; Sequence=VSP_042893; Name=3; IsoId=Q4KMQ2-3; Sequence=VSP_046819; Name=4; IsoId=Q4KMQ2-4; Sequence=VSP_046820
Alternative Sequence
1..23; MKKMSRNVLLQMEEEEDDDDGDI -> MFCAA (in isoform 3); 23; I -> IGDVPASRRPFLTPHTHLPSSL (in isoform 2); 843..910; HVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEAVDNNLRPKSE -> YLALLPRLGHSGMILAHCNLRLPVDCCMCYRFVDEIRLLEQLTSDFIDSLYYIFSISIISIFFSVTFFFLLLSLGPTPCFSVSNFLS (in isoform 4)
Domain & Motif Annotations
Protein Families
Anoctamin family
Sequence Similarities
Belongs to the anoctamin family.
Clinical Relevance5
Drug Targets
Successful target
Antibody
Interaction Protein (2)
ENSG00000127022ENSG00000166523
Interaction Count
2
Interaction Dataset (2)
biogrid_opencellbiogrid_bioplex
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 30865381 | Surfaceome of Exosomes Secreted from the Colorectal Cancer Cell Line SW480: Peripheral and Integral Membrane Proteins Analyzed by Proteolysis and TX114. | No abstract available |
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |