Protein detail
S22A6
Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)
Protein symbol S22A6 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 12 | Protein classification FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1)
Protein Class
FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
10..30; Helical; 136..156; Helical; 165..187; Helical; 191..213; Helical; 225..245; Helical; 249..269; Helical; 338..358; Helical; 369..389; Helical; 396..416; Helical; 426..446; Helical; 456..475; Helical; 485..505; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
OAT1PAHTROAT1
Gene Description
Solute carrier family 22 member 6
Chromosome
11
Position
62936385-62984967
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBergmann gliaBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0005452 solute:inorganic anion antiporter activity
- GO:0005515 protein binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0015132 prostaglandin transmembrane transporter activity
- GO:0015139 alpha-ketoglutarate transmembrane transporter activity
- GO:0015297 antiporter activity
- GO:0015347 sodium-independent organic anion transmembrane transporter activity
- GO:0022857 transmembrane transporter activity
- GO:0031404 chloride ion binding
- GO:0042802 identical protein binding
- GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| mfs | transporter | Surfaceome | No | Yes | No | No | No |
| slc22 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Data-Dependent Acquisition LC-MS/MS | 1 | 32795414 |
Sequence, Structure & Domains
Sequences
Length
563
Mass
61,816
Sequence
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQTRQQQEHQKYMVPLQASAQEKNGL
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=OAT1-1; IsoId=Q4U2R8-1; Sequence=Displayed; Name=2; Synonyms=OAT1-2; IsoId=Q4U2R8-2; Sequence=VSP_032169; Name=3; Synonyms=OAT1-3; IsoId=Q4U2R8-3; Sequence=VSP_032168, VSP_032169; Name=4; Synonyms=OAT1-4; IsoId=Q4U2R8-4; Sequence=VSP_032168
Alternative Sequence
455..498; Missing (in isoform 3 and isoform 4); 523..535; Missing (in isoform 2 and isoform 3)
3D Structural Models
3D Structure
Electron microscopy (8)
Domain & Motif Annotations
Domain (CC)
Multiple cysteine residues are necessary for proper targeting to the plasma membrane.
Region
525..563; Disordered
Protein Families
- Major facilitator (TC 2.A.1) superfamily
- Organic cation transporter (TC 2.A.1.19) family
Sequence Similarities
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs