Protein detail

GAG13

G antigen 13 (GAGE-13) (G antigen 12A) (GAGE-12A)

Entry name GAG13	UniProt ID Q4V321	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

G antigen 13 (GAGE-13) (G antigen 12A) (GAGE-12A)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000274274

Entrez Gene Symbol

GAGE13

Gene Synonym

GAGE12A

Gene Description

G antigen 13

Chromosome

Position

49331582-49338949

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Cell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophage

Function & Pathway3

Protein Function

Predicted intracellular proteins

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Western blottingELISA	3	39290459 37686366 40098346

Sequence, Structure & Domains7

Sequences

Length

117

Mass

12,957

Sequence

MSWRGRSTYYWPRPRRYVEPPEMIGPMRPEQFSDEVEPATPEEGEPATQRQDPAAAQEGEDEGASAGQGPKPEADSQEQGHPQTGCECEDGPDGQEMDPPNPEEVKTPEEGEKQSQC

Domain & Motif Annotations

Compositional Bias

32..45; Acidic residues; 87..96; Acidic residues; 103..117; Basic and acidic residues

Region

1..117; Disordered

Protein Families

GAGE family

Sequence Similarities

Belongs to the GAGE family.

Clinical Relevance1

Antibody

HPA043232

Supporting Publications1

PMID	Title	Abstract
37330168	Serum exosomal m6A demethylase FTO promotes gefitinib resistance in non-small cell lung cancer by up-regulating FLRT3, PTGIS and SIRPα expression.	From this analysis, FTO m6A demethylase was found to be significantly upregulated in the serum exosomes of gefitinib-resistant NSCLC patients.