Protein detail

AT135

Probable cation-transporting ATPase 13A5 (EC 7.2.2.-) (P5-ATPase isoform 5)

Entry name
AT135
UniProt ID
Q4VNC0
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
10
Protein classification
Predicted membrane proteins
Basic Information
Protein Names
Probable cation-transporting ATPase 13A5 (EC 7.2.2.-) (P5-ATPase isoform 5)
Protein Class
Predicted membrane proteins
Transmembrane
33..53; Helical; 222..242; Helical; 401..421; Helical; 433..453; Helical; 903..923; Helical; 940..956; Helical; 973..993; Helical; 1042..1062; Helical; 1077..1097; Helical; 1115..1135; Helical
Transmembrane Count
10
Ensembl
ENSG00000187527
Entrez Gene Symbol
ATP13A5
Gene Synonym
FLJ16025
Gene Description
ATPase 13A5
Chromosome
3
Position
193274789-193378820
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue SpecificretinaCell SpecificRod photoreceptor cells
Function & Pathway
Cellular Component (2)
Molecular Function (6)
Biological Process (3)
Reactome (3)
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence17

Ligand-Receptor Signaling (16)

16 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathYes
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath
transportertransporterSurfaceomeYes
p_atpasetransporterSurfaceomeYes
activetransporterSurfaceomeYes
transportertransporterOmniPathYes
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern BlottingMass Spectrometry136573687
Sequence, Structure & Domains

Sequences

Length
1,218
Mass
137,327
Sequence
MEENSKKDHRALLNQGEEDELEVFGYRDHNVRKAFCLVASVLTCGGLLLVFYWRPQWRVWANCIPCPLQEADTVLLRTTDEFQRYMRKKVFCLYLSTLKFPVSKKWEESLVADRHSVINQALIKPELKLRCMEVQKIRYVWNDLEKRFQKVGLLEDSNSCSDIHQTFGLGLTSEEQEVRRLVCGPNAIEVEIQPIWKLLVKQVLNPFYVFQAFTLTLWLSQGYIEYSVAIIILTVISIVLSVYDLRQQSVKLHNLVEDHNKVQVTIIVKDKGLEELESRLLVPGDILILPGKFSLPCDAVLIDGSCVVNEGMLTGESIPVTKTPLPQMENTMPWKCHSLEDYRKHVLFCGTEVIQVKPSGQGPVRAVVLQTGYNTAKGDLVRSILYPRPLNFKLYSDAFKFIVFLACLGVMGFFYALGVYMYHGVPPKDTVTMALILLTVTVPPVLPAALTIGNVYAQKRLKKKKIFCISPQRINMCGQINLVCFDKTGTLTEDGLDLWGTVPTADNCFQEAHSFASGQAVPWSPLCAAMASCHSLILLNGTIQGDPLDLKMFEGTAWKMEDCIVDSCKFGTSVSNIIKPGPKASKSPVEAIITLCQFPFSSSLQRMSVIAQLAGENHFHVYMKGAPEMVARFCRSETVPKNFPQELRSYTVQGFRVIALAHKTLKMGNLSEVEHLAREKVESELTFLGLLIMENRLKKETKLVLKELSEARIRTVMITGDNLQTAITVAKNSEMIPPGSQVIIVEADEPEEFVPASVTWQLVENQETGPGKKEIYMHTGNSSTPRGEGGSCYHFAMSGKSYQVIFQHFNSLLPKILVNGTVFARMSPGQKSSLIEEFQKLNYYVGMCGDGANDCGALKAAHAGISLSEQEASVASPFTSKTTNIQCVPHLIREGRAALVSSFGVFKYLTMYGIIQFISALLLYWQLQLFGNYQYLMQDVAITLMVCLTMSSTHAYPKLAPYRPAGQLLSPPLLLSIFLNSCFSCIVQISAFLYVKQQPWYCEVYQYSECFLANQSNFSTNVSLERNWTGNATLIPGSILSFETTTLWPITTINYITVAFIFSKGKPFRKPIYTNYIFSFLLLAALGLTIFILFSDFQVIYRGMELIPTITSWRVLILVVALTQFCVAFFVEDSILQNHELWLLIKREFGFYSKSQYRTWQKKLAEDSTWPPINRTDYSGDGKNGFYINGGYESHEQIPKRKLKLGGQPTEQHFWARL

Domain & Motif Annotations

Protein Families (2)
  • Cation transport ATPase (P-type) (TC 3.A.3) family
  • Type V subfamily
Sequence Similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
Clinical Relevance
Antibody (3)
HPA031771HPA031772HPA031774
Supporting Publications2
PMIDTitleRelated sentences
31805958Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.No related sentences available
32854315Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.