Protein detail

CEP55

Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)

Entry name CEP55	UniProt ID Q53EZ4	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Centrosomal protein of 55 kDa (Cep55) (Up-regulated in colon cancer 6)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Ensembl

ENSG00000138180

Entrez Gene Symbol

CEP55

Gene Synonym (3)

C10orf3CT111FLJ10540

Gene Description

Centrosomal protein 55

Chromosome

Position

93496612-93529092

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization5

Cell SpecificEnterocytesSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell SpecificneutrophilBlood Lineage SpecificB-cells

Function & Pathway5

Protein Function (3)

Disease related genes
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Predicted intracellular proteins

Cellular Component (8)

Molecular Function (2)

Biological Process (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence20

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
CEP55	CDK1	P06493	S	428	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:19413330 HPRD:18767875 dbPTM:18691976 phosphoELM:16198290 KEA:16198290 HPRD:18669648 HPRD:19415658 KEA:17081983 dbPTM:19413330 dbPTM:18669648 HPRD:19664994 dbPTM:17081983 HPRD:20068231 HPRD:19691289 dbPTM:16198290 HPRD:16198290 ProtMapper:16198290 SIGNOR:16198290 HPRD:18691976 ProtMapper:29743530 HPRD:18452278
CEP55	CDK1	P06493	S	425	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:19413330 HPRD:16964243 dbPTM:16198290 dbPTM:17081983 ProtMapper:16198290 HPRD:20068231 SIGNOR:16198290 KEA:17081983 HPRD:18691976 KEA:16198290 dbPTM:19413330 phosphoELM:16198290 HPRD:18669648 HPRD:19415658 dbPTM:18669648 ProtMapper:29743530 HPRD:16198290
CEP55	MAPK1	P28482	S	425	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:19413330 HPRD:16964243 dbPTM:16198290 dbPTM:17081983 ProtMapper:16198290 HPRD:20068231 SIGNOR:16198290 KEA:17081983 HPRD:18691976 KEA:16198290 dbPTM:19413330 HPRD:18669648 HPRD:19415658 dbPTM:18669648 ProtMapper:29743530 HPRD:16198290
CEP55	MAPK1	P28482	S	428	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:19413330 HPRD:18767875 dbPTM:18691976 KEA:16198290 HPRD:18669648 HPRD:19415658 KEA:17081983 dbPTM:19413330 dbPTM:18669648 HPRD:19664994 dbPTM:17081983 HPRD:20068231 HPRD:19691289 dbPTM:16198290 HPRD:16198290 ProtMapper:16198290 SIGNOR:16198290 HPRD:18691976 ProtMapper:29743530 HPRD:18452278
CEP55	PLK1	P53350	S	436	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:17446640 HPRD:19664994 HPRD:19413330 HPRD:16964243 dbPTM:16198290 ProtMapper:16198290 HPRD:20068231 SIGNOR:16198290 KEA:17081983 HPRD:19691289 KEA:16198290 dbPTM:19413330 ProtMapper:21079244 HPRD:18669648 ProtMapper:27127172 dbPTM:18669648 ProtMapper:29743530 HPRD:16198290

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CDK1	P06493	CEP55	Q53EZ4	Yes	No	Yes	HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAphosphoELM_KEAHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetELMKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperHPRD-phos	HPRD-phos:19415658 ProtMapper:16964243 HPRD-phos:16964243 dbPTM:18691976 phosphoELM:16198290 HPRD-phos:16198290 HPRD-phos:18669648 HPRD-phos:19691289 KEA:16198290 ProtMapper:19415658 HPRD-phos:18767875 ProtMapper:19413330 ProtMapper:31605944 KEA:17081983 dbPTM:19413330 HPRD-phos:20068231 dbPTM:18669648 ProtMapper:18691976 ProtMapper:19664994 HPRD-phos:18452278 ProtMapper:18767875 dbPTM:17081983 ProtMapper:19691289 HPRD:16198290 dbPTM:16198290 ProtMapper:16198290 ELM:16198290 HPRD-phos:18691976 SIGNOR:16198290 ProtMapper:20068231 HPRD-phos:19413330 ProtMapper:18669648 ProtMapper:18452278 ProtMapper:29743530 HPRD-phos:19664994
MK01	P28482	CEP55	Q53EZ4	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteSparser_ProtMapperHPRD-phos	HPRD-phos:19415658 ProtMapper:16964243 HPRD-phos:16964243 dbPTM:18691976 HPRD-phos:16198290 HPRD-phos:18669648 HPRD-phos:19691289 KEA:16198290 ProtMapper:19415658 HPRD-phos:18767875 ProtMapper:19413330 ProtMapper:31605944 KEA:17081983 dbPTM:19413330 HPRD-phos:20068231 dbPTM:18669648 PhosphoSite:16198290 ProtMapper:18691976 ProtMapper:19664994 HPRD-phos:18452278 ProtMapper:18767875 dbPTM:17081983 ProtMapper:19691289 HPRD:16198290 dbPTM:16198290 ProtMapper:16198290 HPRD-phos:18691976 SIGNOR:16198290 ProtMapper:20068231 HPRD-phos:19413330 ProtMapper:18669648 ProtMapper:18452278 ProtMapper:29743530 HPRD-phos:19664994
PLK1	P53350	CEP55	Q53EZ4	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSite_KEAHPRDPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperHPRD-phos	ProtMapper:16964243 HPRD-phos:16964243 HPRD-phos:16198290 HPRD-phos:18669648 HPRD-phos:19691289 KEA:16198290 ProtMapper:27127172 ProtMapper:19413330 KEA:17081983 dbPTM:19413330 HPRD-phos:20068231 dbPTM:18669648 ProtMapper:19664994 ProtMapper:21079244 ProtMapper:19691289 HPRD:16198290 dbPTM:16198290 ProtMapper:16198290 SIGNOR:16198290 ProtMapper:20068231 HPRD-phos:19413330 ProtMapper:18669648 ProtMapper:29743530 HPRD-phos:19664994

Protein Complex Composition (7)

7 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PPP1R13L-CEP55 complex	CEP55 PPP1R13L	Q53EZ4 Q8WUF5	0:0	CORUM	CORUM:7422	29743530
	BSPRY CEP55 DEAF1	O75398 Q53EZ4 Q5W0U4	0:0:0	hu.MAP2
	CEP55 RBM14 TNK1	Q13470 Q53EZ4 Q96PK6	0:0:0	hu.MAP
	BSPRY C2CD3 CEP131 CEP55 NIN	Q4AC94 Q53EZ4 Q5W0U4 Q8N4C6 Q9UPN4	0:0:0:0:0	hu.MAP2
	CEP55 TEX14	Q53EZ4 Q8IWB6	8:4	PDB	PDB:3wuuPDB:3wut
	CEP55 PDCD6IP	Q53EZ4 Q8WUM4	2:1	PDB	PDB:3e1rPDB:3wuv
	CEP55 TRAPPC12	Q53EZ4 Q8WVT3	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	5	38113368 40189497 32854315 27903962 38207106

Sequence, Structure & Domains10

Sequences

Length

464

Mass

54,178

Sequence

MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTTLLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53EZ4-1; Sequence=Displayed; Name=2; IsoId=Q53EZ4-2; Sequence=VSP_014750, VSP_014751

Alternative Sequence

389..400; NQITQLESLKQL -> KNNTVGILETAS (in isoform 2); 401..464; Missing (in isoform 2)

3D Structural Models

Helix

166..209

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

1..11; Basic and acidic residues

Coiled Coil

22..186; 238..337; 374..403

Region

1..26; Disordered; 157..236; Interaction with TSG101; 160..214; Interaction with PDCD6IP; 355..464; Required for localization to the interphase centrosome and to the midbody during cytokinesis

Clinical Relevance5

Disease Involvement

Disease variant

Antibody

HPA023430

Interaction Protein (10)

ENSG00000074319ENSG00000086589ENSG00000100603ENSG00000117155ENSG00000121101ENSG00000139722ENSG00000141971ENSG00000167987ENSG00000170248ENSG00000185359

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencellintact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
37742368	Long-term hypoxic hUCMSCs-derived extracellular vesicles alleviates allergic rhinitis through triggering immunotolerance of their VEGF-mediated inhibition of dendritic cells maturation.	No abstract available