Protein detail
CTL4
Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1)
Entry name CTL4 | UniProt ID | EVMP confidence score 0.35 |
Supporting publications (n) 0 | Transmembrane count 10 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
- Human disease related genes:Nervous system diseases:Ear disease
Transmembrane
35..55; Helical; 230..250; Helical; 253..273; Helical; 310..330; Helical; 359..379; Helical; 456..476; Helical; 502..522; Helical; 561..581; Helical; 598..618; Helical; 639..659; Helical
Transmembrane Count
10
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
C6orf29CTL4DFNA72FLJ14491NG22TPPT
Gene Description
Solute carrier family 44 member 4
Chromosome
6
Position
31863192-31879046
Supporting publications (n)
0
EVMP confidence score
0.35
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly spermatids
Function & Pathway
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (8)
- R-hsa-1483206 glycerophospholipid biosynthesis
- R-hsa-556833 metabolism of lipids
- R-hsa-1483257 phospholipid metabolism
- R-hsa-9958517 slc mediated bile acid transport
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-1483191 synthesis of pc
- R-hsa-382551 transport of small molecules
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence20
Ligand-Receptor Signaling (19)
19 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| apical_cell_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath | |||||
| receptor | receptor | scConnect | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western blottingMass spectrometryWestern blotting|Reverse phase protein arrayWestern blotting|Reverse phase protein array|Immuno-EM|ELISAWestern blotting|Reverse phase protein array|ELISAReverse phase protein arrayWestern blotting|ELISAELISAReverse phase protein array|Western blotting|ELISA | 1 | 37943341 |
Sequence, Structure & Domains
Sequences
Length
710
Mass
79,254
Sequence
MGGKQRDEDDEAYGKPVKYDPSFRGPIKNRSCTDVICCVLFLLFILGYIVVGIVAWLYGDPRQVLYPRNSTGAYCGMGENKDKPYLLYFNIFSCILSSNIISVAENGLQCPTPQVCVSSCPEDPWTVGKNEFSQTVGEVFYTKNRNFCLPGVPWNMTVITSLQQELCPSFLLPSAPALGRCFPWTNVTPPALPGITNDTTIQQGISGLIDSLNARDISVKIFEDFAQSWYWILVALGVALVLSLLFILLLRLVAGPLVLVLILGVLGVLAYGIYYCWEEYRVLRDKGASISQLGFTTNLSAYQSVQETWLAALIVLAVLEAILLLMLIFLRQRIRIAIALLKEASKAVGQMMSTMFYPLVTFVLLLICIAYWAMTALYLATSGQPQYVLWASNISSPGCEKVPINTSCNPTAHLVNSSCPGLMCVFQGYSSKGLIQRSVFNLQIYGVLGLFWTLNWVLALGQCVLAGAFASFYWAFHKPQDIPTFPLISAFIRTLRYHTGSLAFGALILTLVQIARVILEYIDHKLRGVQNPVARCIMCCFKCCLWCLEKFIKFLNRNAYIMIAIYGKNFCVSAKNAFMLLMRNIVRVVVLDKVTDLLLFFGKLLVVGGVGVLSFFFFSGRIPGLGKDFKSPHLNYYWLPIMTSILGAYVIASGFFSVFGMCVDTLFLCFLEDLERNNGSLDRPYYMSKSLLKILGKKNEAPPDNKKRKK
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q53GD3-1; Sequence=Displayed; Name=2; IsoId=Q53GD3-2; Sequence=VSP_030998; Name=3; IsoId=Q53GD3-3; Sequence=VSP_046236; Name=4; IsoId=Q53GD3-4; Sequence=VSP_046821
Alternative Sequence
1..422; Missing (in isoform 2); 1..76; Missing (in isoform 3); 115..156; Missing (in isoform 4)
Domain & Motif Annotations
Protein Families
CTL (choline transporter-like) family
Sequence Similarities
Belongs to the CTL (choline transporter-like) family.
Clinical Relevance
Disease Involvement (3)
DeafnessDisease variantNon-syndromic deafness
Related Diseases (4)
Biomarker
Phase 1
Drug Targets
Clinical trial target
Drugs