Protein detail
RHG15
Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)
Entry name RHG15 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ARHGAP15 | PAK2 | Q13177 | S | 292 | phosphorylation | PhosphoSite | |
| ARHGAP15 | PAK2 | Q13177 | S | 4 | phosphorylation | PhosphoSite | |
| ARHGAP15 | PAK2 | Q13177 | S | 43 | phosphorylation | PhosphoSite | |
| ARHGAP15 | PAK2 | Q13177 | S | 41 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| RHG15 | Q53QZ3 | RAC1 | P63000 | Yes | No | Yes | HPRDSPIKE_LCSIGNOR | HPRD:12650940SPIKE_LC:12650940SIGNOR:32203420 |
| PAK2 | Q13177 | RHG15 | Q53QZ3 | Yes | No | No | PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper | PhosphoSite:23760270 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
475
Mass
54,544
Sequence
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
3D Structural Models
Turn
309..311; 313..317
Helix
265..270; 283..290; 296..308; 322..333; 343..345; 348..361; 369..379; 384..397; 400..418; 420..423; 427..439; 448..464; 466..470
Beta Strand
362..364; 381..383; 444..446
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1..22; Polar residues
Domain (CC)
The PH domain is required for localization to the membrane.
Domain (FT)
79..189; PH; 281..470; Rho-GAP
Region
1..23; Disordered