Protein detail

RHG15

Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)

Entry name RHG15	UniProt ID Q53QZ3	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000075884

Entrez Gene Symbol

ARHGAP15

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Reactome (4)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence12

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
ARHGAP15	PAK2	Q13177	S	292	phosphorylation	PhosphoSite
ARHGAP15	PAK2	Q13177	S	4	phosphorylation	PhosphoSite
ARHGAP15	PAK2	Q13177	S	43	phosphorylation	PhosphoSite
ARHGAP15	PAK2	Q13177	S	41	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
RHG15	Q53QZ3	RAC1	P63000	Yes	No	Yes	HPRDSPIKE_LCSIGNOR	HPRD:12650940 SPIKE_LC:12650940 SIGNOR:32203420
PAK2	Q13177	RHG15	Q53QZ3	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23760270

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ARHGAP15	Q53QZ3	4	PDB	PDB:3byi

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Data-Dependent Acquisition LC-MS/MS；Gel-LC-MS/MS	2	32795414 26801919

Sequence, Structure & Domains11

Sequences

Length

475

Mass

54,544

Sequence

MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED

3D Structural Models

Turn

309..311; 313..317

Helix

265..270; 283..290; 296..308; 322..333; 343..345; 348..361; 369..379; 384..397; 400..418; 420..423; 427..439; 448..464; 466..470

Beta Strand

362..364; 381..383; 444..446

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1..22; Polar residues

Domain (CC)

The PH domain is required for localization to the membrane.

Domain (FT)

79..189; PH; 281..470; Rho-GAP

Region

1..23; Disordered

Supporting Publications1

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available