Protein detail
CYBR1
Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)
Protein symbol CYBR1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 6 | Protein classification EnzymesMetabolic proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Plasma membrane ascorbate-dependent reductase CYBRD1 (EC 7.2.1.3) (Cytochrome b reductase 1) (Duodenal cytochrome b) (Ferric-chelate reductase 3)
Protein Class
EnzymesMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Transport Electron Carriers
- Enzymes
- ENZYME proteins
Transmembrane
8..32; Helical; Name=1; 48..69; Helical; Name=2; 79..105; Helical; Name=3; 119..144; Helical; Name=4; 152..179; Helical; Name=5; 198..222; Helical; Name=6
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Synonym
CYB561A2DCYTBFLJ23462FRRS3
Gene Description
Cytochrome b reductase 1
Chromosome
2
Position
171522247-171558129
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificEpendymal cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
- Transporters:Transport Electron Carriers
- Enzymes
- ENZYME proteins
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0016491 oxidoreductase activity
- GO:0016722 oxidoreductase activity, acting on metal ions
- GO:0042802 identical protein binding
- GO:0046872 metal ion binding
- GO:0140571 transmembrane ascorbate ferrireductase activity
- GO:0140575 transmembrane monodehydroascorbate reductase activity
Biological Process
Canonical Pathways
- M16801 Sig regulation of the actin cytoskeleton by rho gtpases
- M5193 Sig chemotaxis
- M276 Pid fgf pathway
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CDYLCDYL2CYBRD1MIER1MIER2 | Q53TN4Q8N108Q8N344Q8N8U2Q9Y232 | 0:0:0:0:0 | hu.MAP2 | |||
| CDYLCYBRD1MIER1 | Q53TN4Q8N108Q9Y232 | 0:0:0 | hu.MAP2 | |||
| CDYLCDYL2CYBRD1MIER2 | Q53TN4Q8N344Q8N8U2Q9Y232 | 0:0:0:0 | hu.MAP2 | |||
| CDYLCYBRD1 | Q53TN4Q9Y232 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
286
Mass
31,641
Sequence
MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGGTEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q53TN4-1; Sequence=Displayed; Name=2; IsoId=Q53TN4-2; Sequence=VSP_042039; Name=3; IsoId=Q53TN4-3; Sequence=VSP_044945
Alternative Sequence
1..64; MAMEGYWRFLALLGSALLVGFLSVIFALVWVLHYREGLGWDGSALEFNWHPVLMVTGFVFIQGI -> MLDEGE (in isoform 3); 66..286; IIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFENHNVNNIANMYSLHSWVGLIAVICYLLQLLSGFSVFLLPWAPLSLRAFLMPIHVYSGIVIFGTVIATALMGLTEKLIFSLRDPAYSTFPPEGVFVNTLGLLILVFGALIFWIVTRPQWKRPKEPNSTILHPNGGTEQGARGSMPAYSGNNMDKSDSELNSEVAARKRNLALDEAGQRSTM -> SFRFFSLSASMGSAFSPSISHAHTCLFWNCHLWNSDCNSTYGIDRETDFFPERSCIQYIPARRCFRKYAWPSDPGVRGPHFLDSHQTAMETS (in isoform 2)
3D Structural Models
Turn
187..190
Helix
7..33; 44..47; 49..57; 60..66; 67..70; 72..74; 79..111; 119..142; 149..185; 191..193; 196..219; 222..224
Beta Strand
40..43
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
15..220; Cytochrome b561
Region
229..268; Disordered
Clinical Relevance
Antibody