Protein detail

S45A4

Polyamine-transporter SLC45A4 (Solute carrier family 45 member 4)

Entry name S45A4	UniProt ID Q5BKX6	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 12	Protein classification Predicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Polyamine-transporter SLC45A4 (Solute carrier family 45 member 4)

Protein Class (2)

Predicted membrane proteinsTransporters

Protein Function

Transporters:Electrochemical Potential-driven transporters

Transmembrane

49..79; Helical; Name=1; 89..111; Helical; Name=2; 120..146; Helical; Name=3; 155..186; Helical; Name=4; 192..215; Helical; Name=5; 221..251; Helical; Name=6; 494..535; Helical; Name=7; 549..583; Helical; Name=8; 590..610; Helical; Name=9; 614..649; Helical; Name=10; 660..689; Helical; Name=11; 692..712; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000022567

Entrez Gene Symbol

SLC45A4

Gene Synonym

KIAA1126

Gene Description

Solute carrier family 45 member 4

Chromosome

Position

141207166-141308305

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificLate spermatids

Function & Pathway5

Protein Function

Transporters:Electrochemical Potential-driven transporters

Cellular Component

GO:0016020 membrane

Molecular Function

GO:0008506 sucrose:proton symporter activity

Biological Process (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence17

Ligand-Receptor Signaling (16)

16 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains10

Sequences

Length

768

Mass

83,878

Sequence

MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSIDRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGEPHGVPAFPDEVQSEHELALDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIFHDASYPATPRSTSQELAKTKLPRLATFLKEAAKEDETLLDNHLNEAKVPNGSGSPTKDALGGYTRVDTKPSATSSSMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQYIHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAGEGRAGGNSEKPTVLKLTRKEGLQGPVETESVV

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5BKX6-1; Sequence=Displayed; Name=2; IsoId=Q5BKX6-2; Sequence=VSP_033540, VSP_033541; Name=3; IsoId=Q5BKX6-3; Sequence=VSP_033540, VSP_033541, VSP_033542

Alternative Sequence

1..51; Missing (in isoform 2 and isoform 3); 52..80; WVMHGAVMFGREFCYAMETALVTPILLQI -> MGKASPASGLSRPKTLVSPLRSNQWSLQK (in isoform 2 and isoform 3); 766..768; SVV -> RLQVLTSVRSRHIGWCRSCWRVFFFMIILEKKFSFPQCGSLRRMTYLLFLSELDTLCPGQPCPWAATAHQSWEEAGPGGLGRRQ (in isoform 3)

3D Structural Models

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

473..482; Low complexity

Region

1..32; Disordered; 259..284; Disordered; 379..419; Disordered; 460..489; Disordered; 726..768; Disordered

Protein Families

Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family

Sequence Similarities

Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family.

Clinical Relevance1

Antibody

HPA023154

Supporting Publications2

PMID	Title	Abstract
22329422	Quantitative proteome profiling of normal human circulating microparticles.	No abstract available
30646616	Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells.	THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins.