Protein detail

RIPL1

RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)

Protein symbol RIPL1	UniProt ID Q5EBL4	EVMP score 0.60
Frequency 11	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

Basic Information

Protein Names

RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Ensembl

ENSG00000188026

Entrez Gene Symbol

RILPL1

Gene Synonym

FLJ39378

Gene Description

Rab interacting lysosomal protein like 1

Chromosome

Position

123470054-123533719

Frequency

EVMP Score

0.60

Fluorescence & Localization

Tissue Specificparathyroid glandCell SpecificCytotrophoblastsSingle-Nuclei Brain SpecificoligodendrocyteBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Musculoskeletal diseases:Muscular diseases

Cellular Component

Molecular Function

Biological Process

Canonical Pathways

M58 Pid ar pathway

Mediation Categories

Receptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GTF2E1 RILPL1 TTC39B UBC	P0CG48 P29083 Q5EBL4 Q5VTQ0	1:1:1:1	NetworkBlastCompleat	Compleat:HC5251

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	6	29148239 39989284 41216884 38321535 32089743 39940641

Sequence, Structure & Domains

Sequences

Length

403

Mass

47,108

Sequence

MEEERGSALAAESALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRLERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLSHKDVNFSEEEFQKHEGMSERERQVMKKLKEVVDKQRDEIRAKDRELGLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEPETEPVGEESISDAEKVAMDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEMEEENRIPQPPPIAHPRTSPQPESGIKRLFSFFSRDKKRLANTQRNVHIQESFGQWANTHRDDGYTEQGQEALQHL

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5EBL4-1; Sequence=Displayed; Name=2; IsoId=Q5EBL4-2; Sequence=VSP_027606, VSP_027608; Name=3; IsoId=Q5EBL4-3; Sequence=VSP_027605, VSP_027607

Alternative Sequence

1..151; Missing (in isoform 3); 1..24; Missing (in isoform 2); 152..153; HE -> MT (in isoform 3); 357..403; FSFFSRDKKRLANTQRNVHIQESFGQWANTHRDDGYTEQGQEALQHL -> IFTAIMPMVAAGLIIDDPTLQPVRRLVSLV (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

262..275; Acidic residues; 394..403; Polar residues

Coiled Coil

76..258

Domain (FT)

10..97; RH1; 291..356; RH2

Region

254..275; Disordered; 327..352; Disordered; 384..403; Disordered

Protein Families

RILPL family

Sequence Similarities

Belongs to the RILPL family.

Clinical Relevance

Antibody

HPA041314