Protein detail
PDZ11
PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein)
Protein symbol PDZ11 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification Predicted intracellular proteins |
Basic Information
Protein Names
PDZ domain-containing protein 11 (ATPase-interacting PDZ protein) (Plasma membrane calcium ATPase-interacting single-PDZ protein) (PMCA-interacting single-PDZ protein)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
PDZK11
Gene Description
PDZ domain containing 11
Chromosome
X
Position
70281118-70290514
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskeletal muscleCell SpecificMyonucleiSecretome LocationSecreted in other tissuesSecretome FunctionCell adhesion
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Biological Process
Reactome
- R-hsa-6803157 antimicrobial peptides
- R-hsa-196780 biotin transport and metabolism
- R-hsa-168249 innate immune system
- R-hsa-983712 ion channel transport
- R-hsa-936837 ion transport by p type atpases
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-196849 metabolism of water soluble vitamins and cofactors
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-382551 transport of small molecules
- R-hsa-425397 transport of vitamins nucleosides and related molecules
- R-hsa-199220 vitamin b5 pantothenate metabolism
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
14 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| ecm | ecm | MatrixDB | Yes | No | Yes | No | No |
| ecm | ecm | OmniPath | Yes | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | ComPPI | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | UniProt_location | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | Yes | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PDZ11 | Q5EBL8 | TSN33 | Q86UF1 | Yes | Yes | No | SIGNOR | SIGNOR:30463011 |
| PKHA7 | Q6IQ23 | PDZ11 | Q5EBL8 | Yes | Yes | No | SIGNOR | SIGNOR:30463011 |
Protein Complex Composition
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| PDZD11-nectin1 complex | NECTIN1PDZD11 | Q15223Q5EBL8 | 0:0 | CORUM | CORUM:6611 | 27044745 |
| PDZD11-nectin3 complex | NECTIN3PDZD11 | Q5EBL8Q9NQS3 | 0:0 | CORUM | CORUM:6612 | 27044745 |
| PLEKHA7-PDZD11 complex | PDZD11PLEKHA7 | Q5EBL8Q6IQ23 | 0:0 | CORUM | CORUM:6095 | 27044745 |
Sequence, Structure & Domains
Sequences
Length
140
Mass
16,131
Sequence
MDSRIPYDDYPVVFLPAYENPPAWIPPHERVHHPDYNNELTQFLPRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHRAGLQEGDQVLAVNDVDFQDIEHSKAVEILKTAREISMRVRFFPYNYHRQKERTVH
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=AIPP1a; IsoId=Q5EBL8-1; Sequence=Displayed; Name=2; Synonyms=AIPP1b; IsoId=Q5EBL8-2; Sequence=VSP_015077
Alternative Sequence
1; M -> MGWSCCLKLAGLLSLLNHFLSVLIHSSRALPE (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Domain (FT)
47..129; PDZ
Clinical Relevance
Antibody
Interaction Protein
ENSG00000052126ENSG00000108953ENSG00000165240
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencell