Protein detail
PRRT3
Proline-rich transmembrane protein 3
Entry name PRRT3 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification Predicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Proline-rich transmembrane protein 3
Protein Class (2)
Predicted intracellular proteinsPredicted membrane proteins
Protein Function
Predicted intracellular proteins
Transmembrane
475..495; Helical; 502..522; Helical; 543..563; Helical; 571..591; Helical; 599..619; Helical; 639..659; Helical; 680..700; Helical
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
FLJ33674
Gene Description
Proline rich transmembrane protein 3
Chromosome
3
Position
9939450-9952408
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificBasal keratinocytes
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Biological Process (3)
Mediation Categories
Other mediation
Relations & Evidence11
Ligand-Receptor Signaling (10)
10 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyImmunoaffinity CaptureMicrofluidics-Based Methods | Mass spectrometry | 43 | 32795414291482394121688427863537311969683303581433718342346223203561146239949490413157673976615831508500341086593639856438225453398737264054596339409015386443522898658526801919268848412772398427894104300713183060870030646616309501853370951027312428376863663832153541201090307605383519496531320591320897433792230040311616400914553311476839940641 |
Sequence, Structure & Domains
Sequences
Length
981
Mass
102,197
Sequence
MASSPWGCVCGLLLLLLPLLGTGPALGRGFPRPLENSEIPMIPGAHPKGSVGSEPQAFDVFPENPRADSHRNSDVRHAPAEEMPEKPVASPLGPALYGPKAAQGAQRERLPVTDDLQMAQGPSSHGWTGPLDSQELLQQEAVAPHPVGHPHLTFIPTTPRRQLRVATVPPSLQHEGQEGQWPPRDEGLKAKTKSRVPPTSPSDHQGPPHTLVSHSGTVKRPVLEGQGGFEEHLQEAAQGPHFTQQDPAAPDVGSVPPVEVVYSQEPGAQPDLALARSLPPAEELPVETPKRAGAEVSWEVSSPGPPPKQADLPDAKDSPGPQPTDPPASEAPDRPSKPERAAMNGADPISPQRVRGAVEAPGTPKSLIPGPSDPGPAVNRTESPMGALQPDEAEEWPGRPQSHPPAPPVQAPSTSRRGLIRVTTQRALGQPPPPEPTASSMASAPASSPPANATAPPLRWGPLRRVLSFSWELHVYGVGVLFLLPALLALAALAAAPAGPRLALVAAVLVLVASALRSAYMLTDPYGSQARLGVRGGLVLYNLPFPLLLTALAALTLLGLGAGLPPPLQNPLLLGAVALVHGVGLLATDLLSTWSVLNLLTQGLSCAWGAAVALGTLCLCRRRLLDGPRGWDASPGPRLLAVAGALGLLASGLQLAAALWLYPGPGRVGRFSWAWWGVHFWLRLLELTWALALALAAVAAARPRPPTEHACWAKLMRLACPAPSGKSEVPERPNNCYAGPSNVGAGSLDISKSLIRNPAESGQLATPSSGAWGSAASLGRGPQGGPGLSRNGVGPAPSLSELDLRPPSPINLSRSIDAALFREHLVRDSVFQRCGLRGLASPPPGGALRPRRGSHPKAELDDAGSSLLRGRCRSLSDVRVRGPVPQHVVEAPDGAAAAASGSSLDSFSRGSLKISWNPWRHGLSSVDSLPLDELPSTVQLLPAPTPAPDSTAARQGDGQGEVQPRGKPGESRSASSDTIEL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5FWE3-1; Sequence=Displayed; Name=2; IsoId=Q5FWE3-2; Sequence=VSP_020845; Name=3; IsoId=Q5FWE3-3; Sequence=VSP_020846, VSP_020847
Alternative Sequence
1..384; Missing (in isoform 2); 391..421; DEAEEWPGRPQSHPPAPPVQAPSTSRRGLIR -> GESMAGVWGEGVLCLVTENLCWGCMGAEGGE (in isoform 3); 422..981; Missing (in isoform 3)
Domain & Motif Annotations
Compositional Bias
65..85; Basic and acidic residues; 331..340; Basic and acidic residues; 411..427; Polar residues; 437..457; Low complexity; 765..780; Low complexity; 972..981; Polar residues
Region
43..107; Disordered; 169..457; Disordered; 297..302; O-glycosylated at one site; 759..807; Disordered; 836..865; Disordered; 937..981; Disordered
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 25471207 | Intraluminal proteome and peptidome of human urinary extracellular vesicles. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |