Protein detail

AR13A

ADP-ribosylation factor-like protein 13A (ARF-like GTPase 13A)

Entry name AR13A	UniProt ID Q5H913	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

ADP-ribosylation factor-like protein 13A (ARF-like GTPase 13A)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000174225

Entrez Gene Symbol

ARL13A

Gene Synonym

Gene Description

ADP ribosylation factor like GTPase 13A

Chromosome

Position

100969708-100990831

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (2)

Biological Process (3)

Canonical Pathways (2)

M7955 Sig insulin receptor pathway in cardiac myocytes
M295 Sig pip3 signaling in cardiac myoctes

Mediation Categories

Other mediation

Relations & Evidence3

Ligand-Receptor Signaling (2)

2 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	6	39290459 38225453 40829696 30760538 39001700 40091455

Sequence, Structure & Domains8

Sequences

Length

290

Mass

33,003

Sequence

MFRLLSSCCSCLRTTEETRRNVTIPIIGLNNSGKTVLVEAFQKLLPSKTDHCMKSELTTLLLDEYELSIYDLNGDLKGREAWPNYYAQAHGLVFVLDSSDIRRMQEVKIILTHLLSDKRVAGKPILILANKQDKKKALMPCDIIDYLLLKKLVKENKCPCRVEPCSAIRNLERRNHQPIVEGLRWLLAVIDTCQLPPTSSISISKNNTGSGERCSSHSFSTRTGMSKEKRQHLEQCSIEAKPLKSILQKEGTRLWSKKNMSVTFALDEPMKEGECSRRMRAQNTTKLCYN

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5H913-1; Sequence=Displayed; Name=2; IsoId=Q5H913-2; Sequence=VSP_042678

Alternative Sequence

249..290; KEGTRLWSKKNMSVTFALDEPMKEGECSRRMRAQNTTKLCYN -> PSNQSYTH (in isoform 2)

Domain & Motif Annotations

Region

204..226; Disordered

Protein Families (2)

Small GTPase superfamily
Arf family

Sequence Similarities

Belongs to the small GTPase superfamily. Arf family.

Clinical Relevance1

Antibody (2)

HPA037377 HPA037378

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available