Protein detail
PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)
Entry name PP6R3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Predicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (14)
C11orf23DKFZp781E17107DKFZp781E2374DKFZp781O2362FLJ11058FLJ43065KIAA1558MGC125711MGC125712PP6R3SAP190SAPLSAPLaSAPS3
Gene Description
Protein phosphatase 6 regulatory subunit 3
Chromosome
11
Position
68460731-68615334
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (4)
Molecular Function (3)
Biological Process (3)
Reactome (12)
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-1640170 cell cycle
- R-hsa-73886 chromosome maintenance
- R-hsa-204005 copii mediated vesicle transport
- R-hsa-199977 er to golgi anterograde transport
- R-hsa-180786 extension of telomeres
- R-hsa-199991 membrane trafficking
- R-hsa-597592 post translational protein modification
- R-hsa-171319 telomere extension by telomerase
- R-hsa-157579 telomere maintenance
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Canonical Pathways (2)
- M70 Pid ps1 pathway
- M17 Pid notch pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence20
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PPP6R3 | ATM | Q13315 | S | 537 | phosphorylation | KEA | KEA:17570479 |
| PPP6R3 | PRKCA | P17252 | S | 579 | phosphorylation | KEA | KEA:17570479 |
| PPP6R3 | PRKDC | P78527 | S | 537 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (12)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometryMass spectrometry [LTQ-FT Ultra]Mass spectrometry [QTOF] | 1 | 29045505 |
Sequence, Structure & Domains9
Sequences
Length
873
Mass
97,669
Sequence
MFWKFDLHSSSHIDTLLEREDVTLKELMDEEDVLQECKAQNRKLIEFLLKAECLEDLVSFIIEEPPQDMDEKIRYKYPNISCELLTSDVSQMNDRLGEDESLLMKLYSFLLNDSPLNPLLASFFSKVLSILISRKPEQIVDFLKKKHDFVDLIIKHIGTSAIMDLLLRLLTCIEPPQPRQDVLNWLNEEKIIQRLVEIVHPSQEEDRHSNASQSLCEIVRLSRDQMLQIQNSTEPDPLLATLEKQEIIEQLLSNIFHKEKNESAIVSAIQILLTLLETRRPTFEGHIEICPPGMSHSACSVNKSVLEAIRGRLGSFHELLLEPPKKSVMKTTWGVLDPPVGNTRLNVIRLISSLLQTNTSSINGDLMELNSIGVILNMFFKYTWNNFLHTQVEICIALILASPFENTENATITDQDSTGDNLLLKHLFQKCQLIERILEAWEMNEKKQAEGGRRHGYMGHLTRIANCIVHSTDKGPNSALVQQLIKDLPDEVRERWETFCTSSLGETNKRNTVDLVTTCHIHSSSDDEIDFKETGFSQDSSLQQAFSDYQMQQMTSNFIDQFGFNDEKFADQDDIGNVSFDRVSDINFTLNTNESGNIALFEACCKERIQQFDDGGSDEEDIWEEKHIAFTPESQRRSSSGSTDSEESTDSEEEDGAKQDLFEPSSANTEDKMEVDLSEPPNWSANFDVPMETTHGAPLDSVGSDVWSTEEPMPTKETGWASFSEFTSSLSTKDSLRSNSPVEMETSTEPMDPLTPSAAALAVQPEAAGSVAMEASSDGEEDAESTDKVTETVMNGGMKETLSLTVDAKTETAVFKSEEGKLSTSQDAACKDAEECPETAEAKCAAPRPPSSSPEQRTGQPSAPGDTSVNGPV
Alternative Products
Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q5H9R7-1; Sequence=Displayed; Name=2; IsoId=Q5H9R7-2; Sequence=VSP_017142; Name=3; Synonyms=B, C11orf23b, SAPLb; IsoId=Q5H9R7-3; Sequence=VSP_017140, VSP_017141, VSP_017144; Name=4; Synonyms=A, C11orf23a, SAPLa; IsoId=Q5H9R7-4; Sequence=VSP_017140, VSP_017141; Name=5; IsoId=Q5H9R7-5; Sequence=VSP_017143; Name=6; IsoId=Q5H9R7-6; Sequence=VSP_017141
Alternative Sequence
326..376; Missing (in isoform 3 and isoform 4); 516..544; Missing (in isoform 3, isoform 4 and isoform 6); 544..549; Missing (in isoform 2); 817; S -> RVLKSYR (in isoform 5); 857..873; RTGQPSAPGDTSVNGPV -> SGVEIPALPGQWSQQ (in isoform 3)
Domain & Motif Annotations
Compositional Bias
644..655; Acidic residues; 724..749; Polar residues; 853..873; Polar residues
Region
628..873; Disordered
Protein Families
SAPS family
Sequence Similarities
Belongs to the SAPS family.
Clinical Relevance4
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No abstract available |