Protein detail

CRUM2

Protein crumbs homolog 2 (Crumbs-like protein 2)

Protein symbol CRUM2	UniProt ID Q5IJ48	EVMP score 0.25
Frequency	Transmembrane count 1	Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Basic Information

Protein Names

Protein crumbs homolog 2 (Crumbs-like protein 2)

Protein Class

Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function

Human disease related genes:Urinary system diseases:Kidney diseases
Transporters
Predicted intracellular proteins
Potential drug targets
Disease related genes

Transmembrane

1225..1245; Helical

Transmembrane Count

Ensembl

ENSG00000148204

Entrez Gene Symbol

CRB2

Gene Synonym

FLJ16786FLJ38464

Gene Description

Crumbs cell polarity complex component 2

Chromosome

Position

123356170-123380324

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificEarly spermatidsBlood Lineage Specificdendritic cells

Function & Pathway

Protein Function

Human disease related genes:Urinary system diseases:Kidney diseases
Transporters
Predicted intracellular proteins
Potential drug targets
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04390 Hippo signaling pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_predicted	transmembrane	OmniPath	No	No	Yes	Yes	No
transmembrane	transmembrane	TopDB	No	No	Yes	Yes	No
transmembrane	transmembrane	LOCATE	No	No	Yes	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	Yes	Yes	No
transmembrane	transmembrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	Yes	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	Yes	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	Yes	Yes	No

Page 2 of 3Previous Next

Regulatory Interaction Network

0 records.

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CRB2 DYRK1A	Q13627 Q5IJ48	2:1	PDB	PDB:2wo6

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	6	32795414 32284825 35611462 30646616 33709510 38321535

Sequence, Structure & Domains

Sequences

Length

1,285

Mass

134,265

Sequence

MALARPGTPDPQALASVLLLLLWAPALSLLAGTVPSEPPSACASDPCAPGTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGTHGPFCGQNTTFSVMAGSPIQASVPAGGPLGLALRFRTTLPAGTLATRNDTKESLELALVAATLQATLWSYSTTVLVLRLPDLALNDGHWHQVEVVLHLATLELRLWHEGCPARLCVASGPVALASTASATPLPAGISSAQLGDATFAGCLQDVRVDGHLLLPEDLGENVLLGCERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFANDSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQLQDLGQHVHVGGRLLAADSQPWGGPFRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRGGHGLPGAVLPIPGPRVADGAWHRVRLAMERPAATTSRWLLWLDGAATPVALRGLASDLGFLQGPGAVRILLAENFTGCLGRVALGGLPLPLARPRPGAAPGAREHFASWPGTPAPILGCRGAPVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECICNARFSGQFCEVAKGLPLPLPFPLLEVAVPAACACLLLLLLGLLSGILAARKRRQSEGTYSPSQQEVAGARLEMDSVLKVPPEERLI

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5IJ48-1; Sequence=Displayed; Name=2; IsoId=Q5IJ48-2; Sequence=VSP_014739, VSP_014740; Name=3; IsoId=Q5IJ48-3; Sequence=VSP_014737, VSP_014738

Alternative Sequence

1..332; Missing (in isoform 3); 333..351; GHCQDLPNGFQCHCPDGYA -> MAMEPGALWTFLGHLWLLA (in isoform 3); 1131..1176; LPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP -> WDGWAGGWAANAPWGYGGAEKSARSVDESLPFPGPHVLICDMRRTV (in isoform 2); 1177..1285; Missing (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

67..106; EGF-like 1; 108..144; EGF-like 2; calcium-binding; 146..182; EGF-like 3; calcium-binding; 184..221; EGF-like 4; calcium-binding; 223..259; EGF-like 5; 261..318; EGF-like 6; 320..356; EGF-like 7; calcium-binding; 358..394; EGF-like 8; calcium-binding; 396..436; EGF-like 9; 431..603; Laminin G-like 1; 605..641; EGF-like 10; 647..805; Laminin G-like 2; 807..843; EGF-like 11; 871..1054; Laminin G-like 3; 1056..1092; EGF-like 12; 1094..1130; EGF-like 13; 1134..1171; EGF-like 14; 1173..1209; EGF-like 15

Region

1..350; Required for maximum inhibition of APP amyloid-beta peptide secretion; 1249..1285; Interaction with EPB41L5

Protein Families

Crumbs protein family

Sequence Similarities

Belongs to the Crumbs protein family.

Clinical Relevance

Disease Involvement

Disease variantRetinitis pigmentosa

Antibody

HPA043674