Protein detail

CC038

Uncharacterized protein C3orf38

Entry name CC038	UniProt ID Q5JPI3	EVMP confidence score 0.50
Supporting publications (n) 7	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Uncharacterized protein C3orf38

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000179021

Entrez Gene Symbol

C3orf38

Gene Synonym

MGC26717

Gene Description

Chromosome 3 open reading frame 38

Chromosome

Position

88149959-88168729

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecifictestisCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specifichippocampal CA4Blood Cell Specificbasophil

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component

GO:0005634 nucleus

Molecular Function (2)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence5

Ligand-Receptor Signaling (3)

3 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BAG4 C3orf38	O95429 Q5JPI3	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation		2	40189497 38207106

Sequence, Structure & Domains5

Sequences

Length

329

Mass

37,541

Sequence

MEMSGLSFSEMEGCRNLLGLLDNDEIMALCDTVTNRLVQPQDRQDAVHAILAYSQSAEELLRRRKVHREVIFKYLATQGIVIPPATEKHNLIQHAKDYWQKQPQLKLKETPEPVTKTEDIHLFQQQVKEDKKAEKVDFRRLGEEFCHWFFGLLNSQNPFLGPPQDEWGPQHFWHDVKLRFYYNTSEQNVMDYHGAEIVSLRLLSLVKEEFLFLSPNLDSHGLKCASSPHGLVMVGVAGTVHRGNTCLGIFEQIFGLIRCPFVENTWKIKFINLKIMGESSLAPGTLPKPSVKFEQSDLEAFYNVITVCGTNEVRHNVKQASDSGTGDQV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5JPI3-1; Sequence=Displayed; Name=2; IsoId=Q5JPI3-2; Sequence=VSP_019621

Alternative Sequence

1..2; Missing (in isoform 2)

Clinical Relevance1

Antibody (2)

HPA034736 HPA034737

Supporting Publications7

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
36362114	Extracellular Vesicles in Diffuse Large B Cell Lymphoma: Characterization and Diagnostic Potential.	No abstract available
38107577	Proteomic profiling of serum exosomes reveals acute phase response and promotion of inflammatory and platelet activation pathways in patients with heat stroke.	No abstract available
38441169	Identifying a core protein signature of small extracellular vesicles derived from B-cell precursor acute lymphoblastic leukaemia.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
41216884	Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.	No abstract available
41315767	Multi-omics identify hallmark protein and lipid features of small extracellular vesicles circulating in human plasma.	No abstract available