Protein detail
AMER1
APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)
Protein symbol AMER1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Cancer-related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
FAM123BFLJ39827RP11-403E24.2WTX
Gene Description
APC membrane recruitment protein 1
Chromosome
X
Position
64185117-64205708
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Cancer-related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-196299 beta catenin phosphorylation cascade
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-9711123 cellular response to chemical stress
- R-hsa-195253 degradation of beta catenin by the destruction complex
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9755511 keap1 nfe2l2 pathway
- R-hsa-8951664 neddylation
- R-hsa-597592 post translational protein modification
- R-hsa-4839743 signaling by ctnnb1 phospho site mutants
- R-hsa-195721 signaling by wnt
- R-hsa-4791275 signaling by wnt in cancer
- R-hsa-201681 tcf dependent signaling in response to wnt
Canonical Pathways
M71 Pid ilk pathway
Mediation Categories
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
8 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| AMER1 | Q5JTC6 | CTNB1 | P35222 | Yes | Yes | Yes | WangHINTSIGNORIntAct | SIGNOR:21498506IntAct:17510365HINT:26496610HINT:17510365 |
| AMER1 | Q5JTC6 | AXIN1 | O15169 | Yes | Yes | No | HINTSIGNORIntAct | HINT:17510365SIGNOR:21304492HINT:22682247IntAct:17510365HINT:26496610 |
| AMER1 | Q5JTC6 | KC1G1 | Q9HCP0 | Yes | Yes | No | SIGNOR | SIGNOR:21304492 |
| AMER1 | Q5JTC6 | LRP6 | O75581 | Yes | Yes | No | SIGNOR | SIGNOR:21304492 |
| AMER1 | Q5JTC6 | GSK3B | P49841 | Yes | Yes | No | SIGNOR | SIGNOR:21304492 |
| AMER1 | Q5JTC6 | COMPLEX:O15169_P25054_P49841 | Yes | Yes | No | SIGNOR | SIGNOR:21304492 | |
| AMER1 | Q5JTC6 | APC | P25054 | Yes | Yes | No | HINTSIGNORIntAct | IntAct:24251807SIGNOR:23151663IntAct:17510365HINT:27462415HINT:24251807HINT:26496610 |
| AMER1 | Q5JTC6 | WT1 | P19544 | Yes | Yes | No | SIGNOR | SIGNOR:19416806 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
1,135
Mass
124,029
Sequence
METQKDEAAQAKGAAASGSTREQTAEKGAKNKAAEATEGPTSEPSSSGPGRLKKTAMKLFGGKKGICTLPSFFGGGRSKGSGKGSSKKGLSKSKTHDGLSEAAHGPEDVVSEGTGFSLPLPELPCQFPSSQSAHGALETGSRCKTSVAGATEKAVAEKFPSMPKPKKGLKGFFSSIRRHRKSKVTGAEQSEPGAKGPERVRARPHEHVSSAPQVPCFEETFQAPRKENANPQDAPGPKVSPTPEPSPPATEKMACKDPEKPMEACASAHVQPKPAPEASSLEEPHSPETGEKVVAGEVNPPNGPVGDPLSLLFGDVTSLKSFDSLTGCGDIIAEQDMDSMTDSMASGGQRANRDGTKRSSCLVTYQGGGEEMALPDDDDEEEEEEEEVELEEEEEEVKEEEEDDDLEYLWETAQMYPRPNMNLGYHPTTSPGHHGYMLLDPVRSYPGLAPGELLTPQSDQQESAPNSDEGYYDSTTPGFEDDSGEALGLVRRDCLPRDSYSGDALYEFYEPDDSLENSPPGDDCLYDLHGRSSEMFDPFLNFEPFLSSRPPGAMETEEERLVTIQKQLLYWELRREQLEAQEARAREAHAREAHAREAYTREAYGREAYAREAHTWEAHGREARTREAQAREVRCRETQVRETQARQEKPVLEYQMRPLGPSVMGLAAGVSGTSQISHRGITSAFPTTASSEPDWRDFRPLEKRYEGTCSKKDQSTCLMQLFQSDAMFEPDMQEANFGGSPRRAYPTYSPPEDPEEEEVEKEGNATVSFSQALVEFTSNGNLFSSMSCSSDSDSSFTQNLPELPPMVTFDIADVERDGEGKCEENPEFHNDEDLAASLEAFELGYYHKHAFNNYHSRFYQGLPWGVSSLPRYLGLPGLHPRPPPAAMALNRRSRSLDTAETLEMELSNSHLVQGYLESDELQAQQEDSDEEDEEEEEGEWSRDSPLSLYTEPPGAYDWPAWAPCPLPVGPGPAWISPNQLDRPSSQSPYRQATCCIPPMTMSISLSVPESRAPGESGPQLARPSHLHLPMGPCYNLQPQASQSMRARPRDVLLPVDEPSCSSSSGGFSPSPLPQAKPVGITHGIPQLPRVRPEHPQPQPTHYGPSSLDLSKERAEQGASLATSYSSTAMNGNLAK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Amer1-S1; IsoId=Q5JTC6-1; Sequence=Displayed; Name=2; Synonyms=Amer1-S2, Short; IsoId=Q5JTC6-2; Sequence=VSP_024091, VSP_024092
Alternative Sequence
786..804; MSCSSDSDSSFTQNLPELP -> IRCPGTEDKRQVTQACGTW (in isoform 2); 805..1135; Missing (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
10..19; Low complexity; 23..35; Basic and acidic residues; 36..50; Low complexity; 73..83; Gly residues; 94..107; Basic and acidic residues; 196..208; Basic and acidic residues; 238..248; Pro residues; 253..262; Basic and acidic residues; 282..291; Basic and acidic residues; 373..405; Acidic residues; 455..466; Polar residues; 926..938; Acidic residues; 1058..1069; Low complexity; 1119..1135; Polar residues
Region
1..115; Disordered; 156..308; Disordered; 339..405; Disordered; 447..484; Disordered; 736..764; Disordered; 921..948; Disordered; 1007..1135; Disordered
Protein Families
Amer family
Sequence Similarities
Belongs to the Amer family.