Protein detail

ZNG1C

Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3)

Entry name ZNG1C	UniProt ID Q5JTY5	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Predicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Zinc-regulated GTPase metalloprotein activator 1C (EC 3.6.5.-) (Cobalamin synthase W domain-containing protein 3) (COBW domain-containing protein 3)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000196873

Entrez Gene Symbol

ZNG1C

Gene Synonym (2)

bA561O23.1CBWD3

Gene Description

Zn regulated GTPase metalloprotein activator 1C

Chromosome

Position

68232003-68300035

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization3

Cell SpecificEarly spermatidsSingle-Nuclei Brain Specificendothelial cellBlood Lineage Specificdendritic cells

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

Mediation Categories

Other mediation

Relations & Evidence7

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	LYPD4 SERPINB11 ZNG1C	Q5JTY5 Q6UWN0 Q96P15	0:0:0	hu.MAP2
	SERPINB11 ZNG1C	Q5JTY5 Q96P15	0:0	hu.MAPhu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western BlottingMass Spectrometry	1	36573687

Sequence, Structure & Domains11

Sequences

Length

395

Mass

44,038

Sequence

MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q5JTY5-1; Sequence=Displayed; Name=2; IsoId=Q5JTY5-2; Sequence=VSP_055975

Alternative Sequence

145..164; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

8..20; Acidic residues

Motif

17..24; psi-PxLVp motif; 107..110; CXCC motif

Domain (FT)

274..377; CobW C-terminal

Region

1..22; Disordered

Protein Families (2)

SIMIBI class G3E GTPase family
ZNG1 subfamily

Sequence Similarities

Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.

Clinical Relevance1

Antibody (2)

HPA042759 HPA042813

Supporting Publications1

PMID	Title	Abstract
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available