Protein detail

CAHM4

Calcium homeostasis modulator protein 4 (Protein FAM26D)

Protein symbol CAHM4	UniProt ID Q5JW98	EVMP score 0.50
Frequency 1	Transmembrane count 4	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Calcium homeostasis modulator protein 4 (Protein FAM26D)

Protein Function

Transporters:Transporter channels and pores
Predicted intracellular proteins

Transmembrane

15..37; Helical; Name=S1; 49..71; Helical; Name=S2; 104..129; Helical; Name=S3; 184..207; Helical; Name=S4

Transmembrane Count

Ensembl

ENSG00000164451

Entrez Gene Symbol

CALHM4

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAdipocytesSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function

Transporters:Transporter channels and pores
Predicted intracellular proteins

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0005261 monoatomic cation channel activity

Biological Process

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

3 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CALHM4	Q5JW98	20	PDB	PDB:6ytoPDB:8rmnPDB:6ytqPDB:6ytlPDB:6ytk
CALHM2 CALHM4	Q5JW98 Q9HA72	3:8	PDB	PDB:8rmlPDB:8rmm
CALHM4 PADI3 PADI4	Q5JW98 Q9ULW8 Q9UM07	0:0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	ELISA	2	40784529 40098346

Sequence, Structure & Domains

Sequences

Length

314

Mass

35,060

Sequence

MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKP

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5JW98-1; Sequence=Displayed; Name=2; IsoId=Q5JW98-2; Sequence=VSP_013817; Name=3; IsoId=Q5JW98-3; Sequence=VSP_018252; Name=4; IsoId=Q5JW98-4; Sequence=VSP_045216

Alternative Sequence

1..186; Missing (in isoform 2); 1..164; MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCR -> MAPRSAKETFRINPNVAANL (in isoform 4); 1..143; Missing (in isoform 3)

3D Structural Models

Turn

160..163

Helix

6..14; 16..37; 49..69; 72..81; 95..106; 108..125; 127..132; 143..145; 152..159; 171..207; 217..252; 269..272; 274..276

Beta Strand

45..47

3D Structure

Electron microscopy (7)

Domain & Motif Annotations

Protein Families

CALHM family

Sequence Similarities

Belongs to the CALHM family.

Clinical Relevance